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Kavitha 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.6
At the present time, computerized tests are one of the most critical means to evaluate learning. Choosing tailored questions for each learner is a important part of such tests. Since, wide and varied learners with different abilities are involved, even randomized test cannot serve the purpose of assessment. Some form of personalized and intelligent testing is needed in E-Learning. One of the main components in composing intelligent testing is selecting the items from a huge Item Bank as the accuracy of the test depends on the quality of the assessment which in turn depends on the items selected for assessment. Furthermore, pickingappropriate items is critical in developing as assessment sheet that satisfies multiple criteria. It includes the number of test items, the definitedissemination of course concepts to be assessed, and the expected degree of difficultness and discrimination and exposure frequency. These tests, must effectively select questions from a large item bank, and to manage this problem an optimized assessment sheet composition system using the modified form of nature inspired Intelligent Water Drops optimization algorithm is proposed by embedding a local heuristic as evolutionary operator. This system is designed to choosepersonalizedtest items for each and every learner. Furthermore, the proposed approach is able to effectively generate near optimal items from large item bank that satisfy multiple constraints. The results show that the Evolutionary Intelligent Water Drops approach is suitable for the selection of nearoptimal items from large-scale item bank.
Kavitha R,Rani Thottungal 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.4
This paper presents a novel reconfigurable selective harmonic elimination technique to control harmonics over a wide range of Modulation Indexes (MI) in Multi-Level Inverter (MLI). In the proposed method, the region of the MI is divided into various sectors and expressions are formulated with different switching patterns for each of the sectors. A memetic BBO-MAS (Biogeography Based Optimization - Mesh Adaptive direct Search) optimization algorithm is proposed for solving the Selective Harmonic Elimination - Pulse Width Modulation (SHE-PWM) technique. An experimental prototype is developed using a Field Programmable Gate Array (FPGA) and their FFT spectrums are analyzed over a wide range of MI using a fluke power logger. Simulation and experimental results have validated the performance of the proposed optimization algorithms and the reconfigurable SHE-PWM technique. Further, the sensitivity of the harmonics has been analyzed considering non-integer variations in the magnitude of the input DC sources.
Kavitha, M.,Kalaimagal, I.,Mercy, S.,Sangeetha, N.,Ganesh, D. Institute of Forest Science 2009 Journal of Forest Science Vol.25 No.2
Multiple shoot induction and plant regeneration using apical bud and nodal explants of 100 year old tree of Anthocephalus cadamba, an important sacred and medicinal tree in India was achieved for the first time. Aseptic explants cultured in Murashige and Skoog (MS) medium augmented with different concentrations of BAP (0.1, 0.5, 1.0, 2.5, 5.0 and 10 mg/l), when maintained for 60 days, healthy shoots were induced in presence of BAP (1 mg/l). Lower concentrations of BAP (0.1 - 0.5 mg/l) induced only one shoot per explant. Increase in number of shoots per explant was observed in presence of higher concentrations of BAP (2.5, 5.0 and 10 mg/l). However, elongation of shoots was completely inhibited. Bud break and shoot regeneration was largely associated with seasonal factors. Apical buds cultured during June to August exhibited early bud break within two weeks of initial culture. In rest of the months, bud break and shoot regeneration was very slow irrespective of the various concentrations of BAP used in the medium. Explants sourced from three different maturity levels of shoots indicated that actively growing shoots from the mother plant with 1 - 2 nodal segments was more suitable for culture initiation than the explants collected from mature shoots at dormant stage. Regenerated shoots with 2 - 3 pairs of leaves when transferred to half strength MS medium fortified with IBA (1 mg/l), 60% of the shoots induced healthy roots, indicating the possibility of large scale micropropagation.
Kavitha, Anbukumar,Uma, Govindarajan The Korean Institute of Electrical Engineers 2010 Journal of Electrical Engineering & Technology Vol.5 No.1
Resonant parametric perturbation (RPP) method is an effective non-feedback method for controlling chaos. In this paper, the above method is applied for the current programmed buck-boost dc-dc converter which exhibits chaotic for wide parameter variations. The different possible operating regimes leading to chaotic operation of the current mode controlled buck-boost converter is discussed and the control of chaos by RPP method is demonstrated through computer simulations and experimental studies. The converter is stabilized to period 1 operation practically.
Glucose sensing, photocatalytic and antibacterial properties of graphene-ZnO nanoparticle hybrids
Kavitha, T.,Gopalan, A.I.,Lee, K.P.,Park, S.Y. Pergamon Press ; Elsevier Science Ltd 2012 Carbon Vol.50 No.8
A simple and efficient approach was developed to uniformly decorate graphene nanosheets with zinc oxide (ZnO) nanoparticles. A single source precursor, zinc benzoate dihydrazinate complex, has been used for the in situ generation of ZnO nanoparticles onto graphene at a relatively low temperature, 200<SUP>o</SUP>C. Physico chemical analyses such as X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy revealed that ZnO nanoparticles were finely dispersed on the surface of graphene. ZnO-graphene hybrids were further characterized by Raman spectroscopy and ultraviolet visible spectroscopy and room-temperature photoluminescence. The materials exhibited excellent photocatalytic activity as evident from the degradation of methylene blue in ethanol under UV irradiation. An electrochemical glucose biosensor was fabricated by immobilization of glucose oxidase on the ZnO-graphene hybrids. This biosensor showed improved sensitivity towards glucose as compared to graphene. Also, the hybrids showed significant antibacterial activity against E. coli, gram negative bacteria. This simple and economical preparation strategy may be extended for the preparation of other graphene-based hybrids.
Characterization of a Putative Thioredoxin Peroxidase Prx1 of Candida albicans
Kavitha Srinivasa,최원자,Na-Rae Kim,Jiwon Kim,Minsun Kim,Ju Yun Bae,정우진,김완기 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.3
In this study, we characterized a putative peroxidase Prx1 of Candida albicans by: 1) demonstrating the thiore-doxin-linked peroxidase activity with purified proteins, 2) examining the sensitivity to several oxidants and the accumulation of intracellular reactive oxygen species with a null mutant (prx1∆), a mutant (C69S) with a point mutation at Cys69, and a revertant, and 3) subcelluar localization. Enzymatic assays showed that Prx1 is a thioredoxin-linked peroxidase which reduces both hydrogen peroxide (H2O2) and tert-butyl hydroperoxide (t-BOOH). Compared with two other strong H2O2 scavenger mutants for TSA1 and CAT1, prx1∆ and C69S were less sensitive to H2O2, menadione and diamide at all concentrations tested, but were more sensitive to low concentration of t-BOOH. Intracellular reactive oxygen species accumulated in prx1∆ and C69S cells treated with t-BOOH but not H2O2. These results suggest that peroxidase activity of Prx1 is specified to t-BOOH in cells. In both biochemical and physiological cases, the evolutionarily conserved Cys69 was found to be essential for the function. Immunocytochemical staining revealed Prx1 is localized in the cytosol of yeast cells, but is translocated to the nucleus during the hyphal transition, though the significances of this observation are unclear. Our data suggest that PRX1 has a thioredoxin peroxidase activity reducing both t-BOOH and H2O2, but its cellular function is specified to t-BOOH.
Kavitha, Nowroji,Vijayarathna, Soundararajan,Jothy, Subramanion Lachumy,Oon, Chern Ein,Chen, Yeng,Kanwar, Jagat Rakesh,Sasidharan, Sreenivasan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.
Kavitha, S.,Rajesh Banu, J.,Subitha, G.,Ushani, U.,Yeom, I.T. Elsevier Applied Science 2016 Bioresource technology Vol.219 No.-
The objective of this study was to determine the impact of solubilization during thermo-chemo-sonic pretreatment of waste activated sludge (WAS) on anaerobic biodegradability and cost for biogas production. The results revealed that it was possible to achieve 40-50% of solubilization of WAS when ultrasonic energy input was doubled (11,520-27,000kJ/kgTS). The cost to achieve 30-35% of solubilization of WAS was calculated to be 0.22-0.24USD/L, which was relatively lower than the cost of 0.53-0.8USD/L when 40-50% of solubilisation of WAS was achieved. There was no significant difference in biodegradability (0.60-0.64gCOD/gCOD) for samples with solubilization efficiency of 35-50%. Comparing energetic balance and economic assessment of samples with different solubilization percentages, the results showed that samples with 30-35% of solubilization had lower net cost (7.98-2.33USD/Ton of sludge) and negative energy balance compared to samples with other percentages of solubilization.