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Mohammad Kashfi,Sepehr Goodarzi,Mostafa Rastgou 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.1
Nondestructive experiments are widely employed for determining mechanical properties. In this work, a spherical impact test is virtually performed to determine the plastic properties of a thick aluminum plate. The finite element model is validated experimentally, and several simulations are then performed in accordance with the design of the experiment program. Several algorithms, including support vector machine, Gaussian process regression (GPR), and nonlinear regressions (second- and third-order polynomials) as machine learning techniques, are employed to estimate the material plastic properties. The indentation depth and indentation radius are considered as input variables to predict the tangent modulus (TM) and yield stress (YS). Results reveal that the second-order polynomial and GPR methods realize better performance in terms of determination coefficient and root mean square error criteria in assessing YS.
Iravani, Shahrokh,Kashfi, Seyed Mohammad Hossein,Azimzadeh, Pedram,Lashkari, Mohammad Hossein Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: Colorectal cancer is the third most common type of cancer in males and the second in females in Iran. Males are more likely to develop CRC than women and age is considered as a main risk factor for colorectal cancer. Prevalence of colorectal cancer has been increasing in Asian countries. Aim: The object of this study was to determine the clinical and pathology characteristics of colorectal polyps in Iranian patients and to investigate the variation between our populations with other populations. Materials and Methods: A total of 167 patients with colorectal polyps were included in our study. All underwent colonoscopy during 2009-2013 and specimens were taken through polypectomy and transferred to pathology. All data in patient files including pathology reports were collected and analyzed by SPSS 16 software. A two-tailed test was used and a P-value of < 0.05 was considered significant. Results: Mean age of participants was $57{\pm}15$. Some 84 were females (50.3%) and 83 males (49.7%). Total of 225 polyps were detected which 119 (52.9%) were in males and 106 (47.1%) were in females. Solitary polyps were observed in 124 patients (74%), 26 (15.6%) had two polyps and 17 (10.1%) with more than two polyps (three to five). Rectosigmoid was the site of most of the polyps (63.1%), followed by 19.6% in the descending colon, 7.6% in the transverse, 5.8% in the ascending, and 3.1% in the cecum, data being missing in two cases. Conclusions: Recto sigmoid was site of most of the polyps. The most prevalent type of lesion was adenomatous polyps detected in 78 (34.7%). Mixed hyperplastic adenomatous type observed in 70 (31.1%). This high prevalence of adenomatous polyps in Iranian patients implies the urgent need for screening plans to prevent further healthcare problems with colorectal cancer in the Iranian population.
Purification of bovine liver transglutaminase by gel filtration
Seyyed Mohammad Hossein Razavian,Ali Kashfi and Zohreh Khoshraftar 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.1
Transglutaminases (TGases) are enzymes that catalyze transfer of acyl group and covalent crosslinks formation between peptide-bound glutaminyl residues and amino groups. TGases have many industrial applications and have been purified from various sources. TGase was purified from the bovine liver extract by gel filtration on Sephacryl S-200 HR column. TGase activity was measured using CBZ-l-glutaminylglycine & hydroxylamine and the enzyme was characterized with respect to its response to different temperatures, pHs and salt concentrations. TGase was purified by yield 36.7%, had a weight 74 kDa, a high pH (pH = 8) and temperature (45 °C) optimum. The enzyme was observed to be stable at temperatures below 55 °C and was stable within a narrow pH range of 6.5–8.0. Purified TGase showed Ca2+ dependent characteristics and tended to retain activity at a high NaCl concentration. These results revealed that purified TGase can be used as a potential alternative to other sources.