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Herath, Kalahe Hewage Iresha Nadeeka Madushani,Bing, So Jin,Cho, Jinhee,Kim, Areum,Shin, Sumin,Kim, Gi-Ok,Lee, Jong-chul,Jee, Youngheun EDITIONS SCIENTIFIQUES ELSEVIER 2016 BIOMEDICINE AND PHARMACOTHERAPY Vol.83 No.-
<P><B>Abstract<ce:cross-ref refid='fn0005'> <SUP>2</SUP> </ce:cross-ref> </B></P> <P>Dangyuja (<I>Citrus grandis</I> Osbeck), a citrus cultivated in southern Korea, has been used in traditional medicine for its anti-inflammatory effect. In this study, we investigated the anti-inflammatory potential of extract of <I>Citrus grandis</I> Osbeck (ECGO). In <I>in vitro</I> assays, ECGO treatment of concanavalin A (10μg/ml, for 24h) stimulated splenocytes showed significant reduction in CD44/CD62L<SUP>+</SUP> T cell population and a marked decrease in the production of inflammatory cytokines IL-2, IFN-γ and IL-4. Interestingly, <I>in vivo</I> assays of ECGO topical treatment (100μg/20μl/ear) significantly mitigated the TPA (4μg/20μl/ear) induced edema induction and Myeloperoxidase activity. Anti-inflammatory potential of ECGO were further evidenced through its potent decrease in expression of inducible nitric oxide, cyclooxygenase-2, IL-1β and TNF-α and suppressed homing of CD3<SUP>+</SUP> T cells and F4/80<SUP>+</SUP> macrophages to site of inflammation. This study emphasizes the possibility of developing ECGO as an alternative natural topical agent to combat inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Anti-inflammatory potentials of citrus Dangyuja. </LI> <LI> Topical treatment of ECGO attenuates skin edema. </LI> <LI> ECGO down regulates the pro-inflammatory mediators; iNOS and COX2 to site of inflammation. </LI> </UL> </P>
Madushani Herath, Kalahe Hewage Iresha Nadeeka,Cho, Jinhee,Kim, Areum,Eom, Tae Kil,Kim, Ju-Sung,Kim, Jae-Bum,Doh, Yang Hoi,Jee, Youngheun Elsevier 2018 Journal of Ethnopharmacology Vol.224 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Sasa quelpaertensis</I> Nakai is an edible dwarf bamboo cultivated mainly in Jeju Island, South Korea and its leaf displays various health-promoting properties including antioxidant scavenging.</P> <P><B>Aim of the study</B></P> <P>In this study, we aimed at elucidating its hepatoprotective effect against alcohol-induced fatty liver.</P> <P><B>Methods</B></P> <P>In <I>in vitro</I> study, we evaluated the cytotoxicity and hepatoprotective effect of different solvent fractions (aqua, butanol, chloroform, ethyl acetate and hexane) of 80% EtOH extract of <I>S. quelpaertensis</I> Nakai leaf<I>. In vivo</I> experiment performed using binge alcohol consumption model.</P> <P><B>Results</B></P> <P>Although all five fractions (0–1000 µg/mL) were non-cytotoxic to HepG2 cells, only ethyl acetate fraction (SQEA), rich in phenolic acids such as p-coumaric acid and flavonoids particularly myristin, showed hepatoprotective effect against EtOH (400 mM) in HepG2 cells. Furthermore, SQEA significantly decreased the ethanol induced cell death and enhanced the cell proliferation. In <I>in vivo</I> experiment using binge consumption model (5 g of EtOH/kg body weight in every 12 h for 3 times), SQEA treatment (10, 50 and 100 mg/kg) markedly reduced the alcohol induced histopathological changes and serum EtOH content, and reversed the reduction of glutathione level in ethanol challenged livers. Further, it suppressed the expression of cytochrome P450 2E1 (CYP2E1). In particular, SQEA activated AMP activated protein kinase (AMPK) pathway, and decreased the expression of tumor necrosis factor receptor-1 (TNFR1), which attenuated lipogenesis <I>via</I> decreased expression of fatty acid synthase (FAS). Inhibited lipogenesis due to SQEA treatment directed towards decreased perilipin-2 expression. These results indicate that SQEA has hypolipidemic effect which is mediated by decreased oxidative stress, increased fatty acid oxidation response and decreased lipogenesis.</P> <P><B>Conclusion</B></P> <P>Our results suggest the possibility of developing SQEA as a natural hepatoprotective agent potent in attenuating alcohol-induced fatty liver.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
이온화 방사선으로 인한 피부 손상에 대한 Sulfated Polysaccharide의 보호 효과
김아름,조진희,Kalahe Hewage Iresha Nadeeka Madushani Herath,지영흔 한국키틴키토산학회 2017 한국키틴키토산학회지 Vol.22 No.4
Sulfated polysaccharide (SP), generally known as fucoidan and commonly found in the cell walls of brown algae, has been reported to present biological effects including anti-inflammatory, anticancer, and antioxidant activities. Exposure to ionizing gamma-ray induces cellular production of reactive oxygen species and hair follicular cells, being the most sensitive to gammaray immediately go through apoptosis and damage their rapid differentiation essential for regeneration of hair. In this study we investigated the protective potential of SP’s against gamma-ray induced hair follicle cells injury. For that, 8.5Gy gamma-ray was irradiated to the whole body of C57BL/6 mouse at day 6 after depilation treated with and without SP. Treatment with SP markedly inhibited formation of thiobarbituric acid-reactive substances(TBARS) compared to control group (without SP) after 48 h of irradiation. Increased cleaved caspase-3 and p53 expression by irradiation was decreased by treatment with SP after 8 h of irradiation. Furthermore, terminal deoxyribonucleotidyl transferase-mediated d-uridine 5' triphosphate nick end labelling (TUNEL) staining showed that the proportion of apoptotic cells in gamma-ray irradiated skins was significantly lower in mouse treated with SP than control group (without SP). Also, SP treatment increased the percentage of Ki-67 positive cells compared with those of irradiation only group. These results suggest that SP has potential as a radioprotector for hair follicular cells.