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Naoki Kakuta,Ryuichi Nakano,Akiyo Nakano,Yuki Suzuki,Ayako Tanouchi,Takashi Masui,Saori Horiuchi,Shiro Endo,Risako Kakuta,Yasuo Ono,Hisakazu Yano 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1
Background: Mutations in the quinolone resistance-determining regions (QRDRs) of Acinetobacter baumannii DNA gyrase (gyrA) and topoisomerase IV (parC) are linked to fluoroquinolone (FQ) resistance. We developed a mismatched PCR-restriction fragment length polymorphism (RFLP) assay to detect mutations in the gyrA and parC QRDRs associated with FQ resistance in A. baumannii. Methods: Based on the conserved sequences of A. baumannii gyrA and parC, two primer sets were designed for mismatched PCR-RFLP to detect mutations in gyrA (codons 83 and 87) and parC (codons 80 and 84) by introducing an artificial restriction enzyme cleavage site into the PCR products. This assay was evaluated using 58 A. baumannii strains and 37 other Acinetobacter strains that have been identified by RNA polymerase β-subunit gene sequence analysis. Results: PCR amplification of gyrA and parC was successful for all A. baumannii strains. In 11 FQ -susceptible strains, the gyrA and parC PCR products were digested by the selected restriction enzymes at the site containing gyrA (codons 83 and 87) and parC (codons 80 and 84). PCR products from 47 FQ-resistant strains containing mutations in gyrA and parC were not digested by the restriction enzymes at the site containing the mutation. As for the non-baumannii Acinetobacter strains, although amplification products for gyrA were obtained for 28 strains, no parC amplification product was obtained for any strain. Conclusions: This assay specifically amplified gyrA and parC from A. baumannii and detected A. baumannii gyrA and parC mutations with FQ resistance.
Atsuhito Kakuta,Takaaki Tanaka,Masaaki Chazono,Hirokazu Komaki,Seiichiro Kitasato,Naoya Inagaki,Shoshi Akiyama,Keishi Marumo 한국생체재료학회 2019 생체재료학회지 Vol.23 No.3
Background: It has been reported that the microporous structure of calcium phosphate (CaP) ceramics is important to osteoconduction. Bone morphogenetic protein-2 (BMP-2) has been shown to be a promising alternative to bone grafting and a therapeutic agent promoting bone regeneration when delivered locally. The aim of this study was to evaluate the effects of micro-porosity within beta-tricalcium phosphate (β-TCP) cylinders and local BMP-2 administration on β-TCP resorption and new bone formation. Methods: Bilateral cylindrical bone defects were created in rabbit distal femora, and the defects were filled with β-TCP. Rabbits were divided into 3 groups; defects were filled with a β-TCP cylinder with a total of approximately 60% porosity (Group A: 13.4% micro- and 46.9% macropore, Group B: 38.5% micro- and 20.3% macropore, Group C: the same micro- and macro-porosity as in group B supplemented with BMP-2). Rabbits were sacrificed 4, 8, 12, and 24 weeks postoperatively. Results: The number of TRAP-positive cells and new bone formation in group B were significantly greater than those in group A at every period. The amount of residual β-TCP in group C was less than that in group B at all time periods, resulting in significantly more new bone formation in group C at 8 and 12 weeks. The number of TRAPpositive cells in group C was maximum at 4 weeks. Conclusions: These results suggest that the amount of submicron microporous structure and local BMP-2 administration accelerated both osteoclastic resorption of β-TCP and new bone formation, probably through a coupling-like phenomenon between resorption and new bone formation.
Effect of an amorphous TiO₂addition on dye-sensitized solar cells with organic dyes
Nariaki Kakuta,Takeo Oku,Atsushi Suzuki,Kenji Kikuchi,Shiomi Kikuchi 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.1
Dye-sensitized solar cells with organic dyes of xylenol orange and rose bengal were fabricated and characterized. A solar cell with mixed xylenol orange and rose bengal showed a higher conversion efficiency compared to solar cells with one type of dye. In addition, amorphous TiO2 layers were introduced to attract electrons, which were mixed phases of anatase and amorphous. The current density was improved by the TiO2 layer introduced, and the conversion efficiency increased. Dye-sensitized solar cells with organic dyes of xylenol orange and rose bengal were fabricated and characterized. A solar cell with mixed xylenol orange and rose bengal showed a higher conversion efficiency compared to solar cells with one type of dye. In addition, amorphous TiO2 layers were introduced to attract electrons, which were mixed phases of anatase and amorphous. The current density was improved by the TiO2 layer introduced, and the conversion efficiency increased.
Risako Kakuta,Ryuichi Nakano,Hisakazu Yano,Daiki Ozawa,Nobuo Ohta,Takayuki Matsuoka,Naotaka Motoyoshi,Shunsuke Kawamoto,Yoshikatsu Saiki,Yukio Katori,Mitsuo Kaku 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.3
Dear Editor, Infected aortic aneurysm (IAA) is an uncommon, but life-threatening condition. Identification of the causative pathogen is essential for accurate diagnosis and effective treatment. However, 14–40% of IAA cases are culture-negative [1]. IAA due to Streptococcus pneumoniae is rare, and reports of the involvement of S. pneumoniae capsular serotypes and sequence types (STs) in IAA are even rarer [2-5]. We identified S. pneumoniae from culture-negative IAA by genetic analysis. To the best of our knowledge, as of 2019, only 59 cases of pneumococcal IAA have been reported in France, the United Kingdom (UK), the Netherlands, Germany, Switzerland, Belgium, Denmark, the United States (USA), Canada, Chile, Japan, Hong Kong, Korea, and Austria since 1977 [2-5]. In the previous cases of IAA due to S. pneumoniae, capsular serotype analysis was reported only for seven: 10A and 23F in the UK, 4 and 8 in Denmark, 19F in Hong Kong, 4 in Belgium, and 23 in USA [2-5]. We report the first two cases of culture-negative IAA due to non-vaccine S. pneumoniae serotype 23A, ST338. The study protocol was approved by the Institutional Ethics Committees of Tohoku University, Sendai, Japan (No. 2018-1-456).
Hirokazu Madokoro,Kantarou Kakuta,Ryo Fujisawa,Nobuhiro Shimoi,Kazuhito Sato,Li Xu 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
This paper presents a bed-leaving detection method using Elman-type Counter Propagation Networks (ECPNs), a novel machine-learning-based method used for time-series signals. In our earlier study, we used CPNs, a form of supervised model of Self-Organizing Maps (SOMs), to produce category maps to learn relations among input and teaching signals. For this study, we inserted a feedback loop as the second Grossberg layer for learning time-series features. Moreover, we developed an original caster-stand sensor using piezoelectric films to measure weight changes of a subject on a bed to be loaded through bed legs. The features of our sensor are that it obviates a power supply for operations and that it can be installed on existing beds. We evaluated our sensor system by examining 10 people in an environment representing a clinical site. The mean recognition accuracy for seven behavior patterns is 71.1%. Furthermore, the recognition accuracy for three behavior patterns of sleeping, sitting, and leaving the bed is 83.6% Falsely recognized patterns remained inside of respective categories of sleeping and sitting. We infer that this system is applicable to an actual environment as a novel sensor system requiring no restraint of patients.