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The Efficacy of Herbal Supplement Danggui Buxue Tang for Relieving Menopausal Symptoms
( Eliza L. Y. Wong ),( Annie W. L. Cheung ),( C. J. Haines ),( C. C. Wang ),( Chun-kwok Wong ),( Karl W. K. Tsim ),( William K. F. Cheng ),( Ping-chung Leung ) 대한폐경학회 2022 대한폐경학회지 Vol.28 No.1
Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from menopausal symptoms. Methods: A third clinical trial to determine the clinical efficacy of high-dose DBT for a period of 12 weeks was carried out. The standard Menopause-Specific Quality of Life (MENQOL) assessment chart was used for the evaluation. Safety was defined as an absence of direct estrogenic effects, serum inflammatory cytokines. Notably, interleukin IL-6, IL-8 and tumor necrosis factor TNF-α, known to be directly related to estrogenic reactions in menopause studies, were monitored. Results: The third clinical trial indicated an overall improvement in the four domains of MENQOL, offering further proof of the efficacy of DBT demonstrated in the two previous trials. The serial checks of the three cytokines related to estrogen activities did not show either upward or downward trends. The haphazard behavior reactions of the three cytokines offered indirect indications that DBT improved the MENQOL independently from estrogen activities. Conclusions: The three clinical trials using DBT to relieve menopausal syndrome have offered solid evidence for its efficacy. The uncertainty regarding whether the “phytoestrogen” contained in DBT had bioactivities similar to estrogen was alleviated through the confirmation that no strict estrogenic bioactivities were observed. The issue of safety was further clarified via laboratory platform studies on DBT, which not only showed the lack of similarity with estrogen actions but also confirmed the value of combining the two herbs in the classic formula.
Ha, J.K.,Lee, S.S.,Gao, Z.,Kim, C.-H.,Kim, S.W.,Ko, Jong Y.,Cheng, K.-J. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.7
The effects of various concentrations of saturated fatty acids (SFA; caprylic, capric and stearic acids) on the growth of the anaerobic fungus, Neocallimastix frontalis C5-1 isolated from the rumen of a Korean native goat were investigated. At higher concentrations of fatty acids (0.1%, w/v), the addition of SFA strongly decreased filter paper (FP) cellulose digestion and polysaccharide-degrading enzyme activity. The sensitivity of the rumen anaerobic fungus to the added fatty acids increased in the following order: caprylic ($C_{8:0}$)>capric($C_{10:0}$)>stearic($C_{18:0}$) acid, although stearic acid had no significant (p<0.05) inhibitory effects at any of the concentrations tested. However, the addition of SFA at lower concentrations (0.01 and 0.001% levels), did not inhibit FP cellulose degradation and enzyme activity. Furthermore, although these parameters were slightly stimulated by the addition of SFA, they were not statistically different from control values. This is the first report examining the effects of fatty acids on anaerobic gut fungi. We found that the lower levels of fatty acids used in this experiment were able to stimulate the growth and specific enzyme activities of rumen anaerobic fungi, whereas the higher levels of fatty acids were inhibitory with respect to fungal cellulolysis.
조병호(B. H. Cho),정기원(K. W. Cheng) 한국정보과학회 1992 한국정보과학회 학술발표논문집 Vol.19 No.2
효율적으로 소프트웨어를 개발하기 위하여 생명주기 모델을 설계함에 있어 단계접근(Phased Approach), 시제품화(Prototyping Approach), 증분접근(Incremental Approach), 진화접근(Evolutionary Approach), 위험관리(Risk Management), 변환접근(Conversion Approach)의 개념으로 적용개념을 분류하고 각 소프트웨어 생명주기 개념들을 조사 분석하여 적합한 생명주기 모델 선정을 위한 요소를 도출해서 이를 활용한 평가및 선정 절차를 거쳐 소프트웨어 프로젝트 특성에 맞는 생명 주기 모델을 설계하고 적응하는 방법을 제시하였다.