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        Use of the Layer Analysis Method of the Yellow Emperor's Inner Classic in Modern Society

        고유리,Juntian Liu,Baixiao Zhao 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.6

        This article introduces the Layer Analysis Method of the Yellow Emperor’s Inner Classic text to revive its use in modern acupuncture and medicine. This is a crucial concept, especially for the diagnosis and treatment of diseases by acupuncture. First, the rise and decline of this method is explored. Second, the differentiation of this method is described by symptoms, the affected organs, and the stage of the disease. Third, the treatment method is summarized into four categories: (1) equipment, (2) technique, (3) acupoint, and (4) pathology. The resemblance of the Layer Analysis Method to modern clinical applications is worth examining. The sinew layer is especially fascinating with its similarity to the Anatomy Trains’ track. The skin, vessel, muscle, and bone layers have their respective resemblances to their counterparts in modern medicine. The holism concept of traditional Chinese medicine (TCM) is demonstrated throughout the Layer Analysis Method theory. In addition, the Layer Analysis Method of the Yellow Emperor’s Inner Classic should be reconsidered and complemented by channel-collateral pattern differentiation for acupuncturists to achieve better clinical results. Future research on acupuncture should consider this theory with the channel-collateral pattern differentia- tion theory.

      • KCI등재

        Nicotine Induces the Expression of C-Reactive Protein via MAPK-Dependent Signal Pathway in U937 Macrophages

        Junjun Mao,Juntian Liu,Xiaoming Pang,Ming Li,Jinyan Song,Chunjie Han,Di Wu,Shuyue Wang 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.5

        Atherosclerosis is an inflammatory disease in the vessel wall. Nicotine, a major component of cigarette smoke, is an independent risk factor for cardiovascular diseases including atherosclerosis. As an inflammatory molecule, C- reactive protein (CRP) participates in atherogenesis. Although it has been confirmed that CRP level in smoking patient is significantly higher than non-smokers and cigarette withdrawal,it is unknown whether nicotine induces CRP expression in macrophages. The present study was to observe effect of nicotine on CRP production and the related signal pathway in U937 macrophages. The results showed that nicotine significantly increased mRNA and protein expression of CRP in U937 macrophages in time- and concentration-dependent ways. Nicotinic acetylcholine receptor (nAChR) blocker hexamethonium, MEK1/2 inhibitor PD98059, p38 MAPK inhibitor SB203580 and NF-B inhibitor PDTC almost completely abolished nicotine-induced CRP expression in mRNA and protein levels in U937 macrophages. The further study indicated that hexa-methonium, PD98059, and SB203580 significantly inhibited ERK1/2 and p38 MAPK phosphorylation. These demonstrate that nicotine has ability to induce CRP ex-pression in macrophages through nAChR-ERK1/2/p38 MAPK-NF-B signal pathway, which contributes to better understanding of the pro-inflammatory and pro-atherosclerotic effects of nicotine in cigarette smokers.

      • KCI등재

        Fabrication of hydrophobic ZIFs based composite membrane with high CO2 absorption performance

        Li Xu,Yu Qin,Liying Liu,Juntian Xiao,Zhongwei Ding 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.5

        The membrane contactor has been considered an effective device to capture CO2, but its performance is limited by membrane wetting phenomena. In this work, the ZIF-8/ZIF-L (zeolitic imidazolate framework) based composite membrane with excellent hydrophobic stability and CO2 permeability was successfully fabricated by coating the dense layer on the porous PVDF (polyvinylidene fluoride) substrate. The dense layer was developed by evenly incorporating ZIF-8 nanocrystals and ZIF-L nanosheets into the polydimethylsiloxane (PDMS) polymer. The as-prepared membrane possessed competitive hydrophobicity with a water contact angle (WCA) of 131.8o. And after a ten-day immersion test in CO2 absorbent, the WCA only declined by 9.8%, exhibiting excellent hydrophobic stability. Besides, the CO2 permeability of the composite membrane was 61.8×10-8·mol·m-2·s-1·Pa-1 with an ideal CO2/N2 separation factor of ~20, which was effectively improved in comparison with the control membrane. In the CO2 absorption experiment, the prepared membrane achieved the competitive CO2 flux of 3.02×10-3·mol·m-2·s-1 when the liquid velocity was 0.25m·s-1 and displayed robust long-term operating stability. Finally, the AC impedance technique was applied to continuously monitor the wetting state of composite membranes, which further investigated their anti-wetting ability.

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        A Fluorenone Alkaloid from Caulophyllum robustum Maxim. with Anti-myocardial Ischemia Activity

        Sicen Wang,Binyu Wen,Na Wang,Juntian Liu,Langchong He 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.4

        A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustumMaxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.

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