http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yoon, Jungmin,Kim, Seung Joong,An, Sojin,Cho, Saehyun,Leitner, Alexander,Jung, Taeyang,Aebersold, Ruedi,Hebert, Hans,Cho, Uhn-Soo,Song, Ji-Joon Elsevier 2018 Journal of molecular biology Vol.430 No.6
<P><B>Abstract</B></P> <P>Importin4 transports histone H3/H4 in complex with Asf1a to the nucleus for chromatin assembly. Importin4 recognizes the nuclear localization sequence located at the N-terminal tail of histones. Here, we analyzed the structures and interactions of human Importin4, histones and Asf1a by cross-linking mass spectrometry, X-ray crystallography, negative-stain electron microscopy, small-angle X-ray scattering and integrative modeling. The cross-linking mass spectrometry data showed that the C-terminal region of Importin4 was extensively cross-linked with the histone H3 tail. We determined the crystal structure of the C-terminal region of Importin4 bound to the histone H3 peptide, thus revealing that the acidic patch in Importin4 accommodates the histone H3 tail, and that histone H3 Lys14 contributes to the interaction with Importin4. In addition, we show that Asf1a modulates the binding of histone H3/H4 to Importin4. Furthermore, the molecular architecture of the Importin4_histone H3/H4_Asf1a complex was produced through an integrative modeling approach. Overall, this work provides structural insights into how Importin4 recognizes histones and their chaperone complex.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The C-terminal region of Importin4 extensively interacts with the N-terminal tail of histone H3. </LI> <LI> The crystal structure of the C-terminal region of Importin4 with a histone H3 peptide shows that histone H3 binds to the acidic patch in Importin4. </LI> <LI> Histone H3 K14 is the primary residue interacting with Importin4. </LI> <LI> Asf1a modulates the binding of histone H3/H4 to Importin4. </LI> <LI> The molecular architecture of the Importin4_Histone H3/H4_Asf1a complex was produced through an integrative modeling approach that combined X-ray crystallography, cross-linking mass-spectrometry and negative-stain electron microscopy data. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sanghyeon Yoon,Jungmin Kwak,Deokho Im,Hakyoung Yoon 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.5
Background: Percutaneous renal cyst sclerotherapy (PRCS) as a treatment for renal cysts is usually performed with a high concentration of ethanol (≥ 90%). This study reviewed cases in which a lower concentration of ethanol (83%) was used for the procedure in dogs. Methods: Records of cases of renal cysts treated by sclerotherapy using 83% ethanol in dogs were reviewed. Outcomes of the treatment were evaluated by comparing volumes of renal cysts before the procedure and the volumes after treatment, using ultrasound images with the volume reduction rates classified as follows: < 50% of initial volume (failed); ≥ 50% but < 80% of initial volume (partial success); ≥ 80% but < 95% of initial volume (great success); ≥ 95% of initial volume (complete success). Results: Out of nine dog kidneys, renal cysts sclerotherapy with 83% ethanol achieved partial success in one kidney, great success in four, and complete success in the other four. No side effect was observed. The mean of the volume-reduction rates was 90.00 ± 11.00 while the minimum and maximum reduction rates were 65% and 100%, respectively. Conclusions: The lower ethanol concentration (83%) is good for disinfecting kidneys in PRCS.
Carboxypeptidase E Is a Novel Modulator of RANKL-Induced Osteoclast Differentiation
Kim, Hyun-Ju,Hong, JungMin,Yoon, Hye-Jin,Yoon, Young-Ran,Kim, Shin-Yoon Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.9
Osteoclasts are large polykaryons that have the unique capacity to degrade bone and are generated by the differentiation of myeloid lineage progenitors. To identify the genes involved in osteoclast development, we performed microarray analysis, and we found that carboxypeptidase E (CPE), a prohormone processing enzyme, was highly upregulated in osteoclasts compared with their precursors, bone marrow-derived macrophages (BMMs). Here, we demonstrate a novel role for CPE in receptor activator of NF-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. The overexpression of CPE in BMMs increases the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear osteoclasts and the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), which are key regulators in osteoclastogenesis. Furthermore, employing CPE knockout mice, we show that CPE deficiency attenuates osteoclast formation. Together, our data suggest that CPE might be an important modulator of RANKL-induced osteoclast differentiation.
Yoon, Jinsu,Han, Jungmin,Choi, Bongsik,Lee, Yongwoo,Kim, Yeamin,Park, Jinhee,Lim, Meehyun,Kang, Min-Ho,Kim, Dae Hwan,Kim, Dong Myong,Kim, Sungho,Choi, Sung-Jin American Chemical Society 2018 ACS NANO Vol.12 No.6
<P>Electronics that degrade after stable operation for a desired operating time, called transient electronics, are of great interest in many fields, including biomedical implants, secure memory devices, and environmental sensors. Thus, the development of transient materials is critical for the advancement of transient electronics and their applications. However, previous reports have mostly relied on achieving transience in aqueous solutions, where the transience time is largely predetermined based on the materials initially selected at the beginning of the fabrication. Therefore, accurate control of the transience time is difficult, thereby limiting their application. In this work, we demonstrate transient electronics based on a water-soluble poly(vinyl alcohol) (PVA) substrate on which carbon nanotube (CNT)-based field-effect transistors were fabricated. We regulated the structural parameters of the PVA substrate using a three-dimensional (3D) printer to accurately control and program the transience time of the PVA substrate in water. The 3D printing technology can produce complex objects directly, thus enabling the efficient fabrication of a transient substrate with a prescribed and controlled transience time. In addition, the 3D printer was used to develop a facile method for the selective and partial destruction of electronics.</P> [FIG OMISSION]</BR>
Jungmin Lee,Hagyoul Bae,Jun Seok Hwang,Jaeyeop Ahn,Jun Tae Jang,Jinsoo Yoon,Sung-Jin Choi,Dae Hwan Kim,Dong Myong Kim Institute of Electrical and Electronics Engineers 2015 IEEE transactions on electron devices Vol. No.
<P>We report a technique for separate extraction of extrinsic source/drain (S/D) resistances (R<SUB>Se</SUB>/R<SUB>De</SUB>) and gate bias (V<SUB>GS</SUB>)-dependent but channel length (L)-independent intrinsic source/drain (R<SUB>Si</SUB>/R<SUB>Di</SUB>) resistances for the overlap region in MOSFETs. For extraction of the overlap length (L<SUB>ov</SUB>) in the heavily doped S/D regions, an analytical capacitance model for the depletion region is employed with the gate-to-source and gate-to-drain capacitance-voltage (C<SUB>G-S</SUB>, C<SUB>G-D</SUB>) characteristics. After verifying the extracted overlap length through a 2-D technology computer-aided design simulation, we successfully extract V<SUB>GS</SUB>-dependent R<SUB>Si</SUB> = 0.9~3.7 Ω and R<SUB>Di</SUB> = 1.0~3.9 Ω in an n-channel MOSFET with W = 140 μm and L = 0.35 μm. In addition, V<SUB>GS</SUB>- and L-independent extrinsic S/D resistances are separately extracted to be R<SUB>Se</SUB> = 5.1 Ω and R<SUB>De</SUB> = 5.0 Ω, respectively.</P>