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Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients
Jung-ChulSeo,Sang-WonHan,Chang-SikYin,Hyung-KyunKoh,Chang-HwanKim,Ee-HwaKim,Kang-HyunLeem,Hyang-SookLee,Hi-JoonPark,Soon-AeKim,Bong-KeunChoe,Hee-JaeLee,Sung-VinYim,Chang-JuKim,Joo-HoChung 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.4
Apoptosis has been implicated in the pathogenesis ofneurodegenerative diseases such as stroke and Alzhe-imer's disease. Apo-1/Fas gene is one of the mediatorsof apoptosis in stroke. MvaI polymorphism is the firstpolymorphic marker identified in the Apo-1/Fas genepromoter, which was typed by PCR and folowed byMvaI digestion and gel electrophoresis. DNA isolatedfrom peripheral blood collected from 91 strokepatients and 103 healthy blood donors was used forgenotypes of GG, GA and AA by sequence specificprimer PCR. MvaI polymorphism was examined basedon Fas gene promotor region by restriction fragmentlength polymorphism (RFLP). The Fas-G genotypewas the least frequent in patients with stroke andhealthy controls (P= 0.57). In normal Korean controlsthe MvaI polymorphism GA, AA and GG were 48.6%,34.9% and 16.5%. In stroke patients were 56.2%, 29.6%and 14.2% respectively. And the allelic frequencies ofMvaI*2 (G) alle were les frequent than MvaI*1 (A)alle in patients with stroke and healthy controls(P= 0.76). In normal Korean controls MvaI*1 (A) andMvaI*2 (G) alles were 59.2% and 40.8%. In strokepatients were 57.6% and 42.4%, respectively. Ourresults, pending confirmation in a larger study, indi-cate that the Fas genotype may not apear to be a riskfactor for stroke in Korean stroke patients.
Sutterella faecalis sp. nov., isolated from human faeces
Byeong Seob Oh,JI-SUN KIM,유승엽,Seoung Woo Ryu,SEUNG-HWAN PARK,강세원,박잠언,Seung-Hyeon Choi,Kook-Il Han,Keun Chul Lee,Mi Kyung Eom,Min Kuk Suh,Han Sol Kim,Dong Ho Lee,Hyuk Yoon,김병용,이제희,Jung-SookLee,이주혁 한국미생물학회 2020 The journal of microbiology Vol.58 No.2
An obligately anaerobic, Gram-stain-negative, non-motile, non-spore-forming, and coccobacilli-shaped bacterial strain, designated KGMB03119T, was isolated from human faeces from a Korean. Phylogenetic analysis based on the 16S rRNA gene sequence revealed that the isolate was a member of the genus Sutterella and most closely related to Sutterlla wadsworthensis KCTC 15691T (96.8% 16S rRNA gene sequence similarity). The DNA G + C content of strain KGMB03119T was 58.3 mol% as determined from its whole genome sequence. Strain KGMB03119T was asaccharolytic, catalase-positive, oxidase- and urease-negative. Furthermore, the isolate was positive for alkaline phosphatase, leucine arylamidase, acid phosphatase, arginine arylamidase, alanine arylamidase, and glycine arylamidase. The major cellular fatty acids (> 10%) of the isolate were C18:1ω9c and C16:0. Methylmenaquinone-5 (MMK-5, 100%) was the predominant isoprenoid quinone in the isolate. Based on the phylogenetic, physiological, and chemotaxonomic characteristics, strain KGMB03119T represents a novel species, for which the name Sutterella faecalis sp. nov. is proposed. The type strain is KGMB03119T (= KCTC 15823T = NBRC 114254T).