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Drug-Induced Vitamin Deficiency
( Jung Won Jung ),( So Young Park ),( Hyunah Kim ) 한국정맥경장영양학회 2022 한국정맥경장영양학회지 Vol.14 No.1
Drug-induced vitamin depletion can occur in hospitalized patients due to the administration of specific medications, which could potentially adversely affect patient outcomes. Signs and symptoms related to vitamin deficiency while taking certain medications should be monitored carefully and managed appropriately if those deficiencies are clinically significant. This article reviews potential drug-induced vitamin depletion and discusses the evidence supporting vitamin deficiency related to the use of specific medications.
Eun Jung Thak,Dong-Jik Lee,Hyunah Kim,Ye Ji Son,Jung Ho Kim,Su-Bin Lee,Yong-Sun Bahn,Hyun Ah Kang 한국당과학회 2021 한국당과학회 학술대회 Vol.2021 No.01
The human fungal pathogen Cryptococcus neoformans assembles N-/O-linked glycans on its proteins in two types with and without xylose (1, 2). In this study, the CAP6 gene, encoding an α1,3-mannosyltransferase responsible for the second mannose addition to the minor O-glycans with xylose, was identified and functionally analyzed. The CAP6 deletion in the ktr3Δ strain, in which the α1,2-mannose addition to the major O-glycans is defected, resulted in almost complete blockage of O-glycan extension. Notably, the putative two cell surface sensor proteins, Wml (Wsc/Mid2-Like)1p and Wml2p, were shown to be subjected to minor and major O-mannosylation by Cap6 and Ktr3, respectively. The proteins levels of Wml1 and Wml2 were remarkably decreased in the ktr3Δ cap6Δ mutant, indicating that proper O-mannosylation is essential for their stability. The phosphorylation of Mpk1, induced by tunicamycin, was greatly decreased in the ktr3Δcap6Δ and the wml1Δwml2Δ, supporting an essential role of O-glycans on cell surface sensors in cell wall integrity signaling. As reflecting its defective growth under several stress conditions, the ktr3Δcap6Δ strain showed fully attenuated virulence in a mouse model of cryptococcosis. The delineation of the roles of protein glycosylation in fungal pathogenesis will not only provide a deep insight into the glycan-based fungal infection mechanism but also aid in the development of novel antifungal agents.
Jung, Sun hwa,Choi, Kihang,Pae, Ae Nim,Lee, Jae Kyun,Choo, Hyunah,Keum, Gyochang,Cho, Yong Seo,Min, Sun-Joon The Royal Society of Chemistry 2014 Organic & Biomolecular Chemistry Vol.12 No.47
<P>This article describes the rapid and diversified synthesis of pyrrolidinyl triazoles for the discovery of mitochondrial permeability transition pore (mPTP) blockers. The 1,3-dipolar cycloaddition of ethynyl trifluoroborate with azidopyrrolidine produced a key intermediate, triazolyl trifluoroborate <B>4</B>, which subsequently underwent a Suzuki–Miyaura coupling reaction to afford a series of 1,4-disubstituted triazoles <B>2</B>. Subsequent biological evaluation of these derivatives indicated <B>2ag</B> and <B>2aj</B> as the most potent mPTP blockers exhibiting excellent cytochrome P450 (CYP) stability when compared to the previously reported oxime analogue <B>1</B>. The present work clearly demonstrates that a 1,2,3-triazole can be used as a stable oxime surrogate. Furthermore, it suggests that late-stage diversification through coupling reactions of organotrifluoroborates is suitable for the rapid discovery of biologically active molecules.</P> <P>Graphic Abstract</P><P>Pyrrolidinyl triazoles were synthesized <I>via</I> Huisgen 1,3-dipolar cycloadditions of ethynyl trifluoroborate followed by Suzuki–Miyaura coupling reactions and biologically evaluated as potential mPTP blockers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4ob01967a'> </P>
Kim Hyunah,Jung Da Young,Lee Seung-Hwan,Cho Jae-Hyoung,Yim Hyeon Woo,Kim Hun-Sung 대한의학회 2022 Journal of Korean medical science Vol.37 No.38
Background: We evaluated patients visiting a tertiary university hospital due to a diagnosis of diabetes with a goal of achieving blood glucose control and evaluated blood glucose persistence over 7 years according to the change in blood glucose evident at 3 months after the first visit. Methods: Patients treated from 2009 to 2013 were categorized into four groups according to the change in HbA1c levels during the first 3 months of follow-up (Best_group, ≥ 1.6% decrease; Better_group, 0.5–1.5% decrease; Neutral_group, maintained at −0.4% to +0.4%; Worse_group, ≥ 0.5% increase). Each patient’s blood glucose control status was then monitored for 7 years. The incidence of stroke and acute coronary syndrome during this period was confirmed. Results: Overall, 9,776 patients were included. HbA1c values were lower in the Best_group than in the other groups at all time points (all P < 0.001). The rate of reaching targets of < 6.5% or < 7.0% HbA1c decreased over time; the rate at which the estimated glomerular filtration rate decreased to < 30 or < 60 mL/min/1.73m2 increased over time (all trends, P < 0.01). Conclusion: Blood glucose control status in the first 3 months after initiating hospital care enabled estimation of the patient’s glycemic control status for the next 7 years. In cases with poor initial blood glucose control, a new or more active method of blood glucose control should be sought.
구조해석에 기반한 콘크리트 펌프 트럭의 동적 특성 분석
이현아(Hyunah Lee),한승오(Seungoh Han),이우균(Wookyun Lee),정민영(Minyoung Jung) 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6
Dynamic characteristics of boom structures in a concrete pump truck is analyzed. The enlargement of boom structure is essential part of concrete pump trucks in order to keep pace with high-rise construction trend. Thus, a large scaled boom structure including cylinders, links and so on, is the model to analyze. Dynamic analysis is performed under the most common positions like horizontal and arch positions. For the worst cases, rapid acceleration and deceleration is considered when the analysis is carried out. Dynamic loads profile is generated from multi-body dynamic analysis and those profile is applied as the external loads in dynamic structural analysis. Structural safety of the boom structure is confirmed from kinetic efforts.
Kim, Hyunah,Thak, Eun Jung,Yeon, Ji Yoon,Sohn, Min Jeong,Choo, Jin Ho,Kim, Jeong-Yoon,Kang, Hyun Ah MICROBIOLOGICAL SOCIETY OF KOREA 2018 JOURNAL OF MICROBIOLOGY -SEOUL- Vol.56 No.1
Understanding the characteristics and regulation mechanisms of cell wall integrity (CWI) in yeast is important not only for basic research but also in biotechnological applications. We found significantly different CWIs in two representative strains of the thermotolerant methylotrophic yeast Hansenula polymorpha. Compared to the A16 strain (classified as Ogataea polymorpha), the DL1-L strain (classified as Ogataea parapolymorpha) has a thinner cell wall that was found to be more fragile following long-term cultivation and more sensitive to zymolyase. To gain a deeper insight into this difference, we compared the characteristics of the Mpk1p-mediated CWI signaling pathway in the two strains. While a DL1-L mutant deficient in Mpk1p (<TEX>$mpk1{\Delta}$</TEX>) showed severe growth retardation at both normal and high growth temperatures and in the presence of cell-wall disrupting agents, the A16 <TEX>$mpk1{\Delta}$</TEX> mutant displayed only a mild defect in cell growth. Sorbitol effect on rescuing growth retardation was different in the two <TEX>$mpk1{\Delta}$</TEX> strains, which could partly be ascribed to subtle differences in the activation of HOG pathway. Among the cell wall disruptors evaluated, only caffeine clearly increased phosphorylation of Mpk1p in DL1-L, but not in A16. A transcriptome analysis of the DL1-L strain revealed that caffeine significantly increased the expression of a subset of cell-wall related genes in an Mpk1p-dependent manner, but not the expected Rlm1-target genes. Taken together, our data support an essential role for Mpk1p in maintaining CWI in H. polymorpha, although the requirement for Mpk1p and its regulation under diverse stress conditions varies depending on the strain background.