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Lee, Jeonghun,Jeong, Lipjeong,Jung, Eunkyeong,Ko, Changgon,Seon, Semee,Noh, Joungyoun,Lee, Dongwon Elsevier 2019 Journal of controlled release Vol.304 No.-
<P><B>Abstract</B></P> <P>A blood clot (thrombus) is formed as a final product of the hemostatic process with two major components, a mesh of cross-linked fibrin and platelets activated by high concentration of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>). Thrombus formation impedes blood flow to brain and heart and is a principle cause of life-threatening diseases such as stroke and myocardial infarction. Aspirin has been widely used for the treatment and prevention of various cardiovascular diseases, but is unable to target a thrombus and scavenge a high level of H<SUB>2</SUB>O<SUB>2</SUB>. In this study, we report thrombus targeting aspirin polyconjugate particles (T-APP) as a near infrared imaging agent and on-demand therapeutic agent for thrombotic vascular diseases. T-APP were formulated from H<SUB>2</SUB>O<SUB>2</SUB>-activatable aspirin polyconjugate, fibrin-specific peptides and fluorescent IR780. In mouse models of tail bleeding and arterial thrombosis, T-APP targeted the thrombosed vessels rapidly with excellent specificity. T-APP also exerted highly strong antithrombotic activity in the thrombosed vessel by suppressing anti-inflammatory cytokines and inhibiting platelet activation. Based on the unique features such as specific thrombus targeting, H<SUB>2</SUB>O<SUB>2</SUB> scavenging, and on-demand therapeutic actions, the rationally engineered T-APP have important ramifications on imaging and on-demand therapy of thrombotic disorders.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Noh, Joungyoun,Jung, Eunkyeong,Lee, Jeonghun,Hyun, Hyejin,Hong, Seri,Lee, Dongwon American Chemical Society 2019 Biomacromolecules Vol.20 No.2
<P>Cancer cells have a large amount of ROS (reactive oxygen species) because of disturbed ROS homeostasis. Cancer cells therefore undertake redox adaptation to drive proliferation in tumor environments and even survive during anticancer treatment by upregulating endogenous antioxidants. As one of antioxidant defense systems, heme oxygenase-1 (HO-1) acts as an essential role in tumor development by offering antioxidant bilirubin to protect cancer cells under stress conditions. It can be therefore reasoned that the combination of ROS generation and HO-1 inhibition would exert synergistic anticancer effects through the amplification of oxidative stress and provide a new opportunity for targeted anticancer therapy. To establish targeted anticancer therapy based on amplified oxidative stress, we developed molecularly engineered polymer, termed CZP, which incorporates ROS generating CA (cinnamaldehyde) and HO-1 inhibiting ZnPP (zinc protoporphyrin) in its backbone and could form stable micelles in aqueous solutions. CZP micelles not only elevated oxidative stress but also suppressed the expression of antioxidant HO-1, leading to apoptotic cell death. CZP micelles could also significantly suppress the tumor growth without body weight loss, tumor recurrence, and noticeable toxicity in organs. This study demonstrates that a combination of ROS generation and HO-1inhibition synergistically magnifies oxidative stress to kill cancer cells and oxidative stress amplifying CZP micelles may provide a promising strategy in anticancer treatment.</P> [FIG OMISSION]</BR>
찾아가는 동 주민센터 서비스디자인 : 연희동 주민센터를 중심으로
KyumgMi Lee,JoungYoun Lee 한국서비스디자인학회 2017 서비스디자인융합연구 Vol.1 No.1
이 연구는 서울시의 ‘찾아가는 동 주민센터’사업의 일환으로 서대문구 연희동 주민센터를 주민들을 위한 커뮤니티 공간을 공급자 관점이 아닌 수요자 관점의 행정 공간에 대한 서비스디자인 연구이다. 서비스디자인을 통하여 기존 주민센터가 새로운 주민 커뮤니티 센터로 전환하기 위해 공간, 서비스, 커뮤니케이션을 ‘오픈 키친’이라는 하나의 서비스 콘셉트로 통합되었고 이러한 통합 모델을 통해 서울시 423개 주민센터가 가야 할 방향을 제시하고 확산시키고자 한다. This is a study of service design for the community space at Yeonhee-Dong. Through the service design, the existing resident centers were integrated into a single service concept in order to transform the new resident community center into an ‘Open Kitchen’ service concept. Through this integrated model, 423 community centers in Seoul will present and disseminate directions.
Social TV 의 사용자 경험 디자인 요소 추출에 관한 연구 : 해외 Social TV 의 사례분석을 중심으로
이정연(Joungyoun Lee),이승원(Seongwon Lee) 한국HCI학회 2009 한국HCI학회 학술대회 Vol.2009 No.2
In this paper, we present the results of two studies on Social TV. In one study, meaning and possibility of TV as social media was theoretically studied and based on this meaning, we reviewed existing social TV systems and literatures. By doing this, we could extract the conditions and issues raised by designing Social TV's user experience. Based on our analysis, we could conclude with elements which are (1) channel communication, (2) Co-viewing experience, (3) Interaction Devices and elements, (4) Personalized contents browsing and selecting, (5) Accessibility and usability (6) User interface design. 현 사회는 통신과 방송 융합 시대의 도래와 웹2.0의 영향으로 기존의 단 방향 형식의 TV가 개인화된 양방향 서비스의 TV2.0 를 맞이하고 있다. 인터넷의 쌍방향성을 활용하여 TV를 시청함에 있어서 커뮤니케이션 기능을 부가하여 새로운 사용자 경험을 제공하기 위해 'Social TV'란 명제아래 여러 연구가 활발히 진행되고 있다. 본 연구에서는 이 IPTV의 새로운 성장요소로서의 SocialTV의 사례분석을 통해 사용자 경험 디자인 요소 추출을 진행하였다. 먼저 TV가 지닌 매체적 특성에 대한 이론 연구를 통해 TV가 Social TV로 갖는 의미를 살펴보았다. 그리고 Social TV의 해외 사례분석과 문헌 연구를 중심으로 Social TV를 디자인 할 시 고려되어야 할 사용자 경험 디자인 요소들을 추출하였다. 추출된 요소로는 (1) 커뮤니케이션 채널, (2) 동시 시청에 대한 경험, (3)인터랙션 디바이스와 세부 요소들, (4) 개인화된 콘텐츠 브라우징/검색과 선택, (5) 접근성과 사용성, (6) 사용자 인터페이스로 정리되었다. 향후 연구로는 추출한 인자들을 국내 사용자의 특성에 맞게 재정의하여 향후 국내에서의 Social TV 서비스 개발 시, 유용하게 활용될 가이드라인을 제안해 본다.
Go, Yebin,Lee, Hanui,Jeong, Lipjeong,Sun, Semi,Hong, Eunmi,Jung, Eunkyeong,Ko, Changgon,Noh, Joungyoun,Park, Sanghun,Lee, Moungyoung,Song, Chulgyu,Lee, Dongwon Elsevier 2018 Biomaterials Vol.186 No.-
<P><B>Abstract</B></P> <P>There has been increasing interest in the development of pathological stimulus-activatable nanoplatforms with theranostic functions. Here, we report ketalized maltodextrin (KMD) nanoparticles which are able to deliver therapeutic and imaging functions to the acidic conditions simultaneously, as may be found in the site of inflammation. KMD was synthesized as a platform of the theranostic nanoparticles by conjugating acid-cleavable hydrophobic moieties to maltodextrin through carbonate bonds. KMD nanoparticles could undergo acid-triggered hydrolytic degradation to generate carbon dioxide (CO<SUB>2</SUB>) bubbles, amplifying the ultrasound signal. The potential of KMD nanoparticles as a drug carrier was evaluated using silymarin as a model drug. KMD nanoparticles displayed significantly enhanced ultrasound contrast at acidic pH and released drug payloads in acid-triggered manners. The translational potential of silymarin-loaded KMD (s-KMD) nanoparticles as ultrasound contrast agents and therapeutic agents was thoroughly evaluated using cell culture models and mouse models of acetaminophen (APAP)-induced acute liver failure. s-KMD nanoparticles exhibited significantly enhanced ultrasound contrast in the APAP-intoxicated liver and also remarkably suppressed the hepatic damages by inhibiting the expression of pro-inflammatory cytokines. These results suggest that KMD nanoparticles hold tremendous potential as theranostic agents for various inflammatory diseases.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Dual Imaging-Guided Oxidative-Photothermal Combination Anticancer Therapeutics
Noh, Joungyoun,Jung, Eunkyeong,Yoo, Donghyuck,Kang, Changsun,Kim, Chunho,Park, Sangjun,Khang, Gilson,Lee, Dongwon American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.47
<P>Heme oxygenase-1 (HO-1) is a stress-response protein with potent cytoprotective and antioxidant activity, and its expression in cancer cells is enhanced in response to chemotherapy and radiotherapy. HO-1 is known to serve as a shield to protect cancer cells from anticancer therapy and attenuate apoptotic signals. It can be therefore reasoned that inhibition of HO-1 reduces the antioxidant level, making cancer cells more sensitive to photothermal heating. In this work, we developed dual imaging-guided oxidative-photothermal combination nanotherapeutics (OPCN) consisting of amphiphilic polymers conjugated with zinc protoporphyrin as a HO-1 inhibitor and fluorescent IR820 as a photothermal agent. A combination of OPCN and near-infrared (NIR) laser irradiation markedly increased the temperature and exerted significant toxicity through induction of apoptosis. In a mouse model of xenografts, tumors were identified by the strong fluorescence and photoacoustic signals. OPCN combined with NIR laser irradiation resulted in effective and complete thermal ablation of tumors without discernable side effects and tumor recurrence. We believe that OPCN hold tremendous translational potential for dual imaging-guided oxidative-photothermal combination anticancer therapy.</P> [FIG OMISSION]</BR>