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Woo, Seon Rang,Ham, Yunhee,Kang, Wonyoung,Yang, Heekyoung,Kim, Sujong,Jin, Juyoun,Joo, Kyeung Min,Nam, Do-Hyun Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-
<P>Standard treatment for glioblastoma comprises surgical resection, chemotherapy with temozolomide, and radiotherapy. Nevertheless, majority of glioblastoma patients have recurrence from resistance to the cytotoxic conventional therapies. We examined combinational effects of KML001, an arsenic compound targeting telomeres of chromosomes with temozolomide or irradiation, in glioblastoma cell lines and xenograft models, to overcome the therapeutic limitation of chemoradiation therapy for glioblastoma. Although KML001 alone showed little effects on <I>in vitro</I> survival of glioblastoma cells, cell death by <I>in vitro</I> temozolomide treatment or irradiation was synergistically potentiated by combination with KML001. Since phosphorylated <I>γ</I>-H2AX, cleaved casepase-3, and cleaved PARP were dramatically increased by KML001, the synergistic effects would be mediated by increased DNA damage and subsequent tumor cell apoptosis. Combinatorial effects of KML001 were observed not only in chemo- and radiosensitive glioblastoma cell line, U87MG, but also in the resistant cell line, U251MG. In the U87MG glioblastoma xenograft models, KML001 did not have systemic toxicity but showed synergistic therapeutic effects in combination with temozolomide or irradiation to reduce tumor volumes significantly. These data indicated that KML001 could be a candidate sensitizer to potentiate therapeutic effects of conventional cytotoxic treatment for glioblastoma.</P>
분산환경에서 혼용 뷰 관리기법을 채택한 이질적인 멀티데이타베이스 상호운용 모델 설계
이승용,박재복,김명희,주수종,Lee Seungyong,Park Jaebok,Kim Myunghee,Joo Sujong 한국정보처리학회 2005 정보처리학회논문지D Vol.12 No.4
본 논문에서는 이질 환경의 지역 데이터베이스 시스템(Local DataBase System: LDBS)을 분산 시스템 형태로 통합하고 전역 사용자에게 빠른 질의 처리를 제공하는 멀티 데이터베이스 관리 시스템(Multi-DataBase Management System: MDBMS)을 제안한다. 이를 위해 MDBMS의 구성 요소들의 기능을 정의하고 그들 간의 상호작용을 설계한다 또한, 구성요소 중 전역 뷰 관리자 관점에서 전역 질의에 대한 결과 정보가 전역 뷰 저장소에 모두 저장되어 있는 경우. 전혀 없는 경우, 그리고 일부 저장되어 있는 경우를 비교하여 객체간의 인터페이스 및 메소드 호출에 따른 시퀀스 다이아그램을 통하여 본 시스템의 기능을 정립한다. 마지막으로, 정립된 기능을 토대로 예제 질의를 이용한 각 기능들의 수행과정을 나타내어 구체적으로 설계된 모델을 제안한다. In this paper, we propose the MDBMS(Multi-DataBase Management System) which integrates the LDBMSs(Local DataBase Systems) with heterogeneous environment into distributed system and provides global users with rapidly query process. For designing the MDBMS, we define the functions of components and design the interaction among them. In a point of view of the global view manager in components, we describe the following 3 cases; (1)the case which the results for the global query are all stored to the global view repository, (2)the case which no result exists in the global view repository, and (3)the case which the partial results we stored to the global view repository. By comparing above cases, we establish the functionalities of our MDBMS through the sequence diagram including the interlace of among objects and the method calling. Finally, we propose the model designed in the concrete by showing the executing procedures of each function using sample query on established functions mentioned above.