임산부의 Myeloperoxidase 유전자다형성과 혈중 비타민 C 수준에 따른 모체의 산화 스트레스와 출생체중

박보현(Bohyun Park),김영주(Young-Ju Kim),박은애(Eun Ae Park),이화영(Hwayoung Lee),하은희(Eun-Hee Ha),박종순(Jongsoon Park),김정연(Jeongyoun Kim),홍윤철(Yun-Chul Hong),박혜숙(Hyesook Park) 한국독성학회 2004 Toxicological Research Vol.20 No.3

This study aimed to determine the association of maternal oxidative stress and<br/> adverse pregnancy outcome with serum vitamin C concentration and a myeloperoxidase (MPO)<br/> genetic polymorphism during pregnancy. We investigated 450 pregnant women who visited Ewha<br/> Womans University Hospital for prenatal care during gestational weeks 24~28. During the second trimester,<br/> we measured serum vitamin C levels and urinary 8-hydroxyde-2'-deoxyguanosine (8-OHdG)<br/> and malondialdehyde (MDA) as an oxidative stress biomarker. We determined the presence of a<br/> maternal MPO polymorphism (G-to-A substitution at nucleotide 463) using a PCR-RFLP assay. We<br/> compared the level of oxidative stress and birth weight with the vitamin C concentration and the<br/> presence of the MPO polymorphism. The mean level of maternal oxidative stress tended to be<br/> higher and the birth weight lower for MPO type A/A than for types A/G and G/G. Vitamin C levels<br/> above the 75 percentiles were associated with reduced concentrations of urinary MDA and 8-OHdG<br/> but increased birth weight. Our data demonstrate that oxidative stress and neonatal birth weight are<br/> associated with the MPO genetic polymorphism, with the association modified by the maternal vitamin<br/> C levels.

A New Water Oxidation Catalyst: Lithium Manganese Pyrophosphate with Tunable Mn Valency

Park, Jimin,Kim, Hyunah,Jin, Kyoungsuk,Lee, Byung Ju,Park, Yong-Sun,Kim, Hyungsub,Park, Inchul,Yang, Ki Dong,Jeong, Hui-Yun,Kim, Jongsoon,Hong, Koo Tak,Jang, Ho Won,Kang, Kisuk,Nam, Ki Tae American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.11

<P>The development of a water oxidation catalyst has been a demanding challenge for the realization of overall water-splitting systems. Although intensive studies have explored the role of Mn element in water oxidation catalysis, it has been difficult to understand whether the catalytic capability originates mainly from either the Mn arrangement or the Mn valency. In this study, to decouple these two factors and to investigate the role of Mn valency on catalysis, we selected a new pyrophosphate-based Mn compound (Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB>), which has not been utilized for water oxidation catalysis to date, as a model system. Due to the monophasic behavior of Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> with delithiation, the Mn valency of Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> (<I>x</I> = 0.3, 0.5, 1) can be controlled with negligible change in the crystal framework (e.g., volume change ∼1%). Moreover, inductively coupled plasma mass spectrometry, X-ray photoelectron spectroscopy, ex-situ X-ray absorption near-edge structure, galvanostatic charging–discharging, and cyclic voltammetry analysis indicate that Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> (<I>x</I> = 0.3, 0.5, 1) exhibits high catalytic stability without additional delithiation or phase transformation. Notably, we observed that, as the averaged oxidation state of Mn in Li<SUB>2-<I>x</I></SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> increases from 2 to 3, the catalytic performance is enhanced in the series Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < Li<SUB>1.7</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < Li<SUB>1.5</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> < LiMnP<SUB>2</SUB>O<SUB>7</SUB>. Moreover, Li<SUB>2</SUB>MnP<SUB>2</SUB>O<SUB>7</SUB> itself exhibits superior catalytic performance compared with MnO or MnO<SUB>2</SUB>. Our study provides valuable guidelines for developing an efficient Mn-based catalyst under neutral conditions with controlled Mn valency and atomic arrangement.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-11/ja410223j/production/images/medium/ja-2013-10223j_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja410223j'>ACS Electronic Supporting Info</A></P>

Lab-based Simulation of Carton Clamp Truck Handling - Preliminary FEA and Analysis of Handling Test Courses

Park, Jongmin,Kim, Jongsoon,Kim, Dongkeon,Chang, Sewon,Kim, Ghiseok Korea Society of Packaging Science and Technology 2017 한국포장학회지 Vol.23 No.3

Carton clamp truck is widely perceived as the high-efficient handling equipment of factory premises and warehouse by its capability of palletless handling. Therefore, the significance of a lab-based handling simulation is becoming higher with the growth of clamp truck usage. In this study, preliminary FEA and design of handling test courses for the lab-based simulation of carton clamp truck handling were performed, and the PSD analyses were performed for the modified one for the test course proposed by Park et al. (2017) as well as ASTM D 6055 and ISTA 3B standards. For the vibration in all directions, the vibration energy intensity analyzed by ISTA 3B standard showed higher than that by the other two cases. A FEA was performed for the handling operation of the sudden stop of the clamps after lifting the target HCP (heavyweight refrigerator corrugated package, w=180 kgf) up to the specified height. The slip distance between the clamp arm and the target HCP was 0.85 mm. The simulation result of 0.85 mm was 3.7 times lower than the experimental result (3.2 mm) obtained by Park et al. (2017), and it was estimated that the deviation comes from both the experimental error by weight imbalance of target HCP, and excessive simplification during the FE modelling of target HCP.

문화·생태관광인프라로서 자연사박물관 건립방안에 관한 연구

박종순,박창수 한국관광정책학회 2000 觀光政策學硏究 Vol.6 No.2

In the late 20th, the urbanization of korea is above 80 percentage. So demands of the eco-tourism is increasing. The natural resources, eco-tourism education system and eco-tourism infrastructure are the most important factors for the eco-tourism. But, the eco-tourism system is not setup yet in korea. After Culture and Tourism Ministry's announcing for the plan of the national natural history museum, Some of provinces has done theirs best to invite the national natural history museum to their town or natural arena. and Others has tried to induce the capital for the erect of the natural history museum. Most of them has a project which is afoot to construct the natural history museum in the natural park of suburban because of the cost of construction. It runs into opposition of ecologist and NGO, conservationist. So, in this study, I tried to review thoroughly the location, function, operation system, and construction of foreign natural history museum, and to setup the theories and philosophies of the natural history museum as the the Cultural Eco-Tourism Infrastructure. and it is presented the lay out a scheme for the construction the natural history museum, location, building up the Cultural Eco-Tourism Infrastructure in this study.

A Study on Surface, Thermal and Mechanical Properties of Absorbable PLGA Plate

JongSoon Park,SoonKook Kang 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.6

Effect of Mn in Li₃V_2–<i>x</i>Mn_<i>x</i>(PO₄)₃ as High Capacity Cathodes for Lithium Batteries

Park, Jae-Sang,Kim, Jongsoon,Park, Woon Bae,Sun, Yang-Kook,Myung, Seung-Taek American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.46

<P>Li3V2-xMnx(PO4)(3) (x = 0, 0.05) cathode materials, which allow extraction of 3 mol of Li from the formula unit, were investigated to achieve a high energy density utilizing multielectron reactions, activated by the V3+/5+ redox reaction. Structural investigation demonstrates that V3+ was replaced by equivalent Mn3+, as confirmed by Rietveld refinement of the Xray diffraction data and X-ray absorption near edge spectroscopy. The substitution simultaneously lowered the band gap energy from 3.4 to 3.2 eV, according to a density functional theory calculation. In addition to the effect of Mn doping, surface carbonization of Li3V2-xMnx(PO4)(3) (x = 0, 0.05) dramatically increased the electric conductivity up to 10(-3) S cm(-1). As a result, the carbon-coated Li3V2-xMnx(PO4)(3) (x = 0.05) delivered a high discharge (reduction) capacity of approximately 180 mAh g(-1) at a current of 20 mA g(-1) (0.1 C rate) with excellent retention, delivering approximately 163 mAh g(-1) at the 200th cycle. Even at 50 C (10 A g(-1)), the electrode afforded a discharge capacity of 68 mAh g(-1) and delivered approximately 104 mAh g(-1) (1 C) at -10 degrees C with the help of Mn doping and carbon coating. The synergetic effects such as a lowered band gap energy by Mn doping and high electric conductivity associated with carbon coating are responsible for the superior electrode performances, including thermal properties with extremely low exothermic heat generation (<0.4 J g(-1) for Li0.02V1.95Mn0.05(PO4)(3)), which is compatible with the layered high energy density of LiNi0.8Co0.15Al0.05O2 and LiNi0.8Co0.1Mn0.1O2 materials.</P>

Factors that Affect the Phase Behavior of Multi-Component Olivine (LiFe<i>_x</i>Mn<i>_y</i>Co_{1-<i>x</i>-<i>y</i>}PO₄; 0 < <i>x</i>, <i>y</i>< 1) in Lithium Rechargeable Batteries: One-Phase Reaction vs. Two-Phase

Park, Kyu-Young,Hong, Jihyun,Kim, Jongsoon,Park, Young-Uk,Kim, Haegyeom,Seo, Dong-Hwa,Kim, Sung-Wook,Choi, Jang-Wook,Kang, Kisuk The Electrochemical Society 2013 Journal of the Electrochemical Society Vol.160 No.3

<P>The structural evolution of multi-component olivines upon delithiation and lithiation was investigated by ex-situ X-ray diffraction. We found that one-phase de/lithiation occurs for multi-component olivines for a fairly large compositional range of transition metal species given that two-phase de/lithiation is generally accepted for olivine cathodes. We discuss the driving force that determines the phase behavior (two-phase reaction vs. one-phase reaction) of olivines in terms of enthalpy of mixing presumably dominated from the electrostatic interaction among cations and the elastic strain stored in the crystal due to the volume change of redox active element. We believe that this fundamental study on the phase behavior of olivines will provide insight into the intrinsic electrochemical properties of olivine electrodes for rechargeable lithium batteries. (C) 2013 The Electrochemical Society. [DOI: 10.114912.036303jes] All rights reserved.</P>

Anti-Site Reordering in LiFePO₄: Defect Annihilation on Charge Carrier Injection

Park, Kyu-Young,Park, Inchul,Kim, Hyungsub,Lim, Hee-dae,Hong, Jihyun,Kim, Jongsoon,Kang, Kisuk American Chemical Society 2014 Chemistry of materials Vol.26 No.18

<P>Defects critically affect the properties of materials. Thus, controlling the defect concentration often plays a pivotal role in determining performance. In lithium rechargeable batteries, the operating mechanism is based on ion transport, so large numbers of defects in the electrode crystal can significantly impede Li ion diffusion, leading to decreased electrochemical properties. Here, we introduce a new way to heal defects in crystals by a room-temperature electrochemical annealing process. We show that defects in olivine LiFePO<SUB>4</SUB>, an important cathode material, are significantly reduced by the electrochemical recombination of Li/Fe anti-sites. The healed LiFePO<SUB>4</SUB> recovers its high-power capabilities. The types of defects in LiFePO<SUB>4</SUB> and recombination mechanisms are discussed with the aid of first-principles calculations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2014/cmatex.2014.26.issue-18/cm502432q/production/images/medium/cm-2014-02432q_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm502432q'>ACS Electronic Supporting Info</A></P>

A study on the phenomenon of non uniformity at isolate pattern using ion beam etching

Jongsoon PARK,Jongkyu KIM,Sangkuk KIM,Woohyun LEE,Ilhyeong LEE,Jongchul PARK,Kyongsub SHIN,Ho-Kyu KANG,Es JUNG,Seokwoo NAM 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Thermal stability of Fe–Mn binary olivine cathodes for Li rechargeable batteries

Kim, Jongsoon,Park, Kyu-Young,Park, Inchul,Yoo, Jung-Keun,Hong, Jihyun,Kang, Kisuk The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.24

<P>The phase stability of binary Fe and Mn olivine materials is extensively studied with temperature-controlled <I>in situ</I> X-ray diffraction (XRD) for various Fe/Mn ratios and state of charges (SOCs). We identify that the thermal behavior of partially charged olivine materials is sensitively affected by the Fe/Mn ratio in the crystal. While Fe-rich binary olivine materials readily formed a solid solution phase of Li<SUB>1−<I>y</I></SUB>Fe<SUB>1−<I>x</I></SUB>Mn<SUB><I>x</I></SUB>PO<SUB>4</SUB> near room temperature or with only slight heating, the Mn-rich binary olivine retained its two-phase characteristic up to <I>ca.</I> 250 °C before decomposition into non-olivine phases. The thermal stability and decomposition mechanism of fully delithiated olivine materials are more sensitively affected by the Fe/Mn ratio in the crystal. The decomposition temperature varies from 200 °C to 500 °C among the different Fe/Mn ratios. It is generally observed that the Mn-rich binary olivine materials are inferior to the Fe-rich ones with respect to the thermal stability in the delithiated state.</P> <P>Graphic Abstract</P><P>The phase stability of Fe–Mn binary olivine cathodes was investigated as a function of the temperature and the Li composition in the structure with temperature-controlled in situ XRD. Fully lithiated LiFe<SUB>1-x</SUB>Mn<SUB>x</SUB>PO<SUB>4</SUB> (0 ≤ x < 1) remained stable up to high temperatures (> 700 °C). However, the thermal stability of delithiated Li<SUB>1-y</SUB>Fe<SUB>1-x</SUB>Mn<SUB>x</SUB>PO<SUB>4</SUB> (0 ≤ x, y ≤ 1) was influenced sensitively by the Fe/Mn content in the structure. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm30733b'> </P>