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Jo, Inho,Hah, Jong S.,Rampal, Amrit L.,Chakrabarti, Ranjan,Paterson, Alan R.P.,Craik, James D.,Cass, Carol E.,Zobel, C. Richard,Jung, Chan Y. 이화여자대학교 생명과학연구소 1992 생명과학연구논문집 Vol.3 No.-
In order to delineate the insulin-independent(constitutive)and insulin-dependent regulations of the plasma membrane glucose transporter concentrations in rat adipocytes, we introduced purified human erythrocyte GLUT-1(HEGT) into rat adipocytes by poly(ethylene glycol)-induced vesicle-cell fusion and its transport function and subcellular distribution in the host cell were measured. HEGT in adipocytes catalysed 3-O-methylglucose equilibrium exchange with a turnover number that is indistinguishable from that of the basal adipocyte transporters. However, insulin did not stimulate significantly the HEGT funciton in adipocytes where it stimulated the native transporter function by 7-8-fold. The steady state distribution and the transmembrane orientation assays revealed that more than 85% of the HEGT that were inserted in the physiological, cytoplasmic side-in orientation at the adipocytes plasma membrane were moved into low-density microsomes(LDM), while 90% of the HEGT that were inserted in the wrong, cytoplasmic side-out orientation were retained in the plasma membrane. Furthermore, more than 70% of the LDM-associated HEGT were found in asmall subset of LDM that also contained 80% of the LDM-associated GLUT-4, the insulin-regulatable, native adipocyte glucose transporter. However, insulin did not cause redistribution of HEGT from LDM to the plasma membrane under the condition where it recruited GLUT-4 from LDM to increase the plasmamembrane GLUT-4 content 4-5-fold. These results demonstrate that the erythrocyte GLUT-1 introduced in adipocytes transports glucose with an intrinsic activity similar to that of the adipocyte GLUT-1 and / or GLUT-4, and enters the constitutive GLUT-4 recruitment pathway. We suggested that the adipocyte plasma membrane glucose transporter concentration is constivutively kept low by a mechanism where a cell-specific constitutent interacts with a cytoplasmic domain common to GLUT-1 and GLUT-4, while the insulin-dependent recruitment requires a cytoplasmic domain specific to GLUT-4.
Jo, Sangmee A.,Ahn, Kyungsook,Kim, Eunkyung,Kim, Hwa-Su,Jo, Inho,Kim, Doh Kwan,Han, Changsoo,Park, Moon Ho S. Karger AG 2008 Dementia and geriatric cognitive disorders Vol.25 No.2
<P><I>Background:</I> β-Site amyloid precursor protein cleaving enzyme (BACE) is a candidate risk factor for Alzheimer’s disease (AD) from its key role in β-amyloid generation. Previous genetic association studies of <I>BACE1</I> gene have yielded conflicting results. This study is an attempt to clarify whether the common SNP in exon 5 of <I>BACE1</I> (rs638405, Val262) is associated with a risk for late-onset AD. <I>Methods:</I> We genotyped a synonymous C/G polymorphism of <I>BACE1</I> located in exon 5 and apolipoprotein E (ApoE) in 248 AD patients and 224 healthy persons. A meta-analysis with pooled data from four Chinese studies and our results was performed. <I>Results:</I> The allele and genotype frequencies of <I>BACE1</I> polymorphism were not significantly different between cases and controls (p > 0.05) in the Korean population. A meta-analysis of previously published Asian populations including Koreans showed evidence of a weak association (p = 0.0555 for genotypes, p = 0.0352 for alleles). However, a significant association between the CC genotype and AD was observed in the ApoE-ε4-positive groups (p = 0.0044, OR = 1.995; 95% CI = 1.319-3.018). <I>Conclusion:</I> These data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset AD in those carrying the ApoE ε4 allele.</P><P>Copyright © 2008 S. Karger AG, Basel</P>
연속해석 데이터의 상호운용성을 지원하는 CAE 미들웨어와 가시화 시스템의 개발
송인호(Inho Song),양정삼(Jeongsam Yang),조현제(Hyunjei Jo),최상수(Sangsu Choi) (사)한국CDE학회 2010 한국CDE학회 논문집 Vol.15 No.2
This paper proposes a CAE data translation and visualization technique that can verify time-varying continuous analysis simulation in a virtual reality (VR) environment. In previous research, the use of CAE analysis data has been problematic because of the lack of any interactive simulation controls for visualizing continuous simulation data. Moreover, the research on post-processing methods for real-time verification of CAE analysis data has not been sufficient. We therefore propose a scene graph based visualization method and a post-processing method for supporting interoperability of continuous CAE analysis data. These methods can continuously visualize static analysis data independently of any timeline; it can also continuously visualize dynamic analysis data that varies in relation to the timeline. The visualization system for continuous simulation data, which includes a CAE middleware that interfaces with various formats of CAE analysis data as well as functions for visualizing continuous simulation data and operational functions, enables users to verify simulation results with more realistic scenes. We also use the system to do a performance evaluation with regard to the visualization of continuous simulation data.
조종수,Jo Inho 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.2
Bone morphogenic protein-2 (BMP-2)-conjugated three-dimensional (3-D)-printed poly (L-lactic acid)(PLLA) scaffold is likely promising as an effective bone substitute for enhancing bone regeneration of massive bone defects caused by tumor resection, traumatic injury, or congenital diseases. The authors developed a new bone substitute using a novel strategy composed of 3-D-printed PLLA scaffolds through a sequential coating of catechol-conjugated alginate (C-AL), BMP-2, and collagen (CO). The 3-D-printed PLLA scaffold was successfully obtained with 5 mm of diameter, 1 mm of thickness, 400 μm of pore size, 187–230 μm of grid thickness, and 82% of porosity. Alkaline phosphatase (ALP) activity of the BMP-2-immobilized PLLA scaffold in MC3T3-E1 and W-20-17 cells was more increased than BMP-2 itself due to the controlled release of BMP-2 from the scaffold. Tenfold new bone formation for the BMP-2-immobilized PLLA scaffold was obtained by micro-CT analysis than PLLA scaffold without BMP-2 weeks after 4 weeks of transplantation model mouse. Further another big animal model study should be performed before clinical trials.
HAH, JONGSIK,JO, INHO,CHAKRABARTI, R.,JUNG, CHAN Y. 이화여자대학교 생명과학연구소 1992 생명과학연구논문집 Vol.3 No.-
The subcellular distribution of glucose transporters in rat hepatocytes and HepG2 cells was stuidied in the absence and in the presence of insulin. Glucose transporters were quantitated by measuring glucose-sensitive cytochalasin B binding and by protein immunoblotting using isoform-specific antibodies. Plasma membrane contamination into subcellular fractions was assesessed by measuring distribution of 5'-nucleotidase and cell surface carbohydrate label. In hepatocyles, GLUT-2 occurred in a low-density microsomal (LDM) faction at a significant concentration, and as much as 15% of cellular GLUT-2 was found intracellularly that cannot be accounted for by plasma membrane contamination. In HepG2 cells which express GLUT-1 and GLUT-2, the two isoforms showed distinct subcellular distribution patterns: GLUT-2 was highly concentrated in LDM while very little GLUT-1 was found in this fraction, indicating that a large portion of GLUT-2 occurs in intracellular organelles. Insulin treatment did not change the subcellular distribution patterns of glucose transporters in both cell types. Our results suggest that rat hepatocytes and HepG2 cells possess an intracellular storage pool for GLUT-2, but lack the insulin-responsive glucose transporter translocation mechanism.