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Eunju Park,Jiye Park,Yunjung Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study investigated the protective effect of hydroponic-cultured ginseng(HG) against oxidative stress induced by H₂O₂ and demonstrated the protection against scopolamine induced memory impairment in mice. Neuronal cytotoxicity induced by H₂O₂ was diminished by two-year-old HG(HG-2, 5~100 μg/mL) detected by MTT assay. Strong protection against H₂O₂-induced DNA damage was also shown in HG-2 treated SK-H-SH cells measured by Comet assay. in vivo study, HG-2(150 mg/kg/d) and six-year-old ginseng(G-6;150 mg/kg/d) were administered orally to six-week-old mice for two weeks, followed by the induction of memory impairment by scopolamine(1 mg/kg/d, i.p.) for one week. At the end of the experimental period, cognitive behavior was examined by NORT and Y-maze tests. In NORT, effect of HG-2 was similar to that of the normal group and donepezil. In Y-maze test, performances of HG-2 and G-6 treated mice were similar to that of donepezil. Behavioral tests showed that the mice treated with HG-2 had improved cognitive function compared to that in mice administered G-6.Therefore, these results suggest that HG-2 could be a potential functional substance for improving cognitive function.
Protective Effects of Hydroponic-Cultured Ginseng on Scopolamine-Induced Memory Impairment in Mice
Eunju Park,Jiye Park,Yunjung Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was performed to investigate the effect of hydroponic-cultured ginseng(HG) on memory improvement in the scopolamine-induced memory-deficient mouse model. Six-week-old male ICR mice were administerd orally by either two-year-old HG(HG-2) or six-year-old ginseng (G-6)(150 mg/kg/d, respectively) for two weeks and then treated with scopolamine(1 mg/kg/d, i.p.) for one week. The effects of HG-2 and G-6 were compared with those of Donepezil(2 mg/kg/d, p.o.), commonly used to treat confusion(dementia) related to Alzheimer’s disease. Oral administration of HG-2 and G-6 suppressed the scopolamine-mediated increase in acetylcholinesterase activity in the brain tissue. HG-2 group significantly increased choline acetyltransferase activity and decreased β-secretase activity in brain tissue than scopolamine-treated control group. In addition, HG-2 group showed a higher protective effect against scopolamine-induced DNA damage in leukocyte and brain tissue than in the G-6 or Donepezil treated groups. These results suggest that HG-2 could be a useful therapeutic agent for neurodegenerative disorders, notably Alzheimer’s disease(AD).
안전한 WEB of Things 응용을 위한 개체 인증 기술
박지예(Jiye Park),강남희(Namhi Kang) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.5B
WoT(Web of Things)는 웹 표준화 기술을 이용하여 사물간 지능화 통신을 실체화하기 위해 제안된 기술이다. WoT 환경은 LLN(Low-power, Lossy Network)과 자원이 제한적인 센서 장치 등을 포함하고 있으므로 기존 인터넷 환경에 적용했던 보안 기술들을 그대로 적용하기는 어렵다. 최근 IETF 표준화 그룹에서는 WoT 환경에서 보안서비스를 제공하기 위해 DTLS 프로토콜을 이용한 방안이 제시되었다. 하지만 DTLS 프로토콜은 사전 설정(핸드 쉐이킹) 과정의 복잡성과 전송되는 메시지양이 많아 WoT 환경에서 종단간 보안 서비스를 제공하기에는 무리가 있다. 본 논문에서는 이를 개선하기 위해 WoT 환경을 DTLS 적용 가능 구간과 경량화 보안 기술이 적용될 구간으로 나누고, 경량화 구간을 위한 상호 인증 및 세션키 분배 시스템을 제안한다. 제안하는 시스템은 사용자의 관리가 용이한 스마트기기를 모바일 게이트웨이 및 WoT 프락시로 사용한다. 제안기술은 ISO 9798 표준화 기술을 수정하여 메시지 전송량을 줄이고 암호 프리미티브 계산량을 감소시키도록 했다. 또한 제안 기술은 재전송 공격, 스푸핑 공격, 선택 평문/암호문 공격, 및 DoS 공격 등에 대응 할 수 있다. WoT (Web of Things) was proposed to realize intelligent thing to thing communications using WEB standard technology. It is difficult to adapt security protocols suited for existing Internet communications into WoT directly because WoT includes LLN(Low-power, Lossy Network) and resource constrained sensor devices. Recently, IETF standard group propose to use DTLS protocol for supporting security services in WoT environments. However, DTLS protocol is not an efficient solution for supporting end to end security in WoT since it introduces complex handshaking procedures and high communication overheads. We, therefore, divide WoT environment into two areas- one is DTLS enabled area and the other is an area using lightweight security scheme in order to improve them. Then we propose a mutual authentication scheme and a session key distribution scheme for the second area. The proposed system utilizes a smart device as a mobile gateway and WoT proxy. In the proposed authentication scheme, we modify the ISO 9798 standard to reduce both communication overhead and computing time of cryptographic primitives. In addition, our scheme is able to defend against replay attacks, spoofing attacks, select plaintext/ciphertext attacks, and DoS attacks, etc.
사물 인터넷 환경에서 경량화 장치 간 상호 인증 및 세션키 합의 기술
박지예(Jiye Park),신새미(Saemi Shin),강남희(Namhi Kang) 한국통신학회 2013 韓國通信學會論文誌 Vol.38 No.9(네트워크)
사물인터넷(IoT) 기술은 M2M 통신의 확장 기술로 구성 장치(사물)들을 인터넷에 연결시켜 사물지능통신을 실체화하기 위해 제안되었다. IoT를 구성하는 다양한 사물들은 일반적으로 자원이 제한적이고, 이기종 장치들은 저용량 네트워크로 상호 연결된다. 이러한 IoT 환경에서 보안 서비스를 제공하기 위해서는 기밀성, 상호인증, 메시지 송신 인증 등이 제공되어야 한다. 그러나 자원이 제한적인 환경 특성상 기존 인터넷 환경에 적용했던 보안 기술들을 그대로 적용하기에는 무리가 있다. IETF 표준화 그룹에서는 안전한 IoT 서비스를 위해 경량화된 DTLS(Datagram TLS) 프로토콜의 적용을 제안하고 있지만 초경량 장치까지 모든 장치를 수용할 수는 없다. 이를 해결하기 위해 본 논문에서는 자원 제약의 이유로 해쉬 함수 혹은 암호 함수와 같은 단일 보안 모듈만을 탑재할 수 있는 경량화 장치들이 상호 인증하고 세션키를 합의할 수 있는 방안을 제안한다. 제안 기술은 세션키 생성 시사전 계산 방식을 통해 성능을 향상시킬 수 있고 다양한 보안 공격에 대응 할 수 있다. IoT, which can be regarded as an enhanced version of M2M communication technology, was proposed to realize intelligent thing to thing communications by utilizing Internet connectivity. Things in IoT are generally heterogeneous and resource constrained. Also such things are connected with each other over LLN(low power and lossy Network). Confidentiality, mutual authentication and message origin authentication are required to make a secure service in IoT. Security protocols used in traditional IP Networks cannot be directly adopted to resource constrained devices in IoT. Under the respect, a IETF standard group proposes to use lightweight version of DTLS protocol for supporting security services in IoT environments. However, the protocol can not cover up all of very constrained devices. To solve the problem, we propose a scheme which tends to support mutual authentication and session key agreement between devices that contain only a single crypto primitive module such as hash function or cipher function because of resource constrained property. The proposed scheme enhances performance by pre-computing a session key and is able to defend various attacks.