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Dong Xinyuan,Si Jiali,Zhang Guanghui,Shen Zhen,Zhang Li,Sheng Kangliang,Wang Jingmin,Kong Xiaowei,Zha Xiangdong,Wang Yongzhong 한국미생물학회 2021 The journal of microbiology Vol.59 No.8
Arthrobotrys oligospora is a model species of nematophagous fungi and has great potential for the biological control of nematode diseases. Lectin is a protein that binds to carbohydrates and their complexes with high specificity, which mediates recognition events in various physiological and pathological processes. This study aimed to investigate the role of the Jacalin-related lectin (JRL) gene, AOL_s00083g511, in A. oligospora development. Through a homology recombination approach, we obtained the AOL_s00083g511 knockout mutant strain (Δg511). Next, the biological characteristics of the Δg511 mutant strain, including growth rate, conidia germination rate, adaptation to environmental stresses, and nematocidal activity, were compared with those of the wild-type (WT) strain. The results showed that the JRL gene AOL_ s00083g511 did not affect fungal growth, conidia germination, 3D-trap formation, and the ability of A. oligospora to prey on nematodes significantly. We speculate that this phenomenon may be caused by a loss of the key β1–β2 loops in the AOL_ s00083g511-encoded JRL domain and an intrinsic genetic compensation of AOL_s00083g511 in this fungus. The growth rates of both strains on high salt or surfactant media were similar; however, in the strong oxidation medium, the growth rate of the Δg511 mutant was significantly lower than that of the WT strain, indicating that AOL_s00083g511 might play a role in oxidative stress resistance. These findings provide a basis for further analysis of the related functions of the JRL gene in A. oligospora and their potential roles in the biological control of nematodes in the future.
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群像特征、潜存风险与价值引领: 2023 年度热词背后的青年社会心态研究
李白(Bai Li),张静敏(Jingmin Zhang) YIXIN 출판사 2024 Journal of China Studies Vol.2 No.3
年度热词具有总结和预测作用,是考察青年社会心态的重要维度。2023 年度热词反映出当代青年普遍关注国家社会发展大势与科技前沿动态,他们的数字和科技素养普遍提升;拥有热爱生活和积极向上的乐观心态;具备一定的自我调节能力。同时,青年群体在后疫情时代显现的新型消费理念传达出正向心态变化。但是,部分负面热词也暴露了青年的社会心态偏差,他们对当下现状表示无力和焦虑、 存在社交孤闭和社交标签化的困境、受到了盲从心理的侵扰、部分负面热词的使用暴露出不良宣泄倾向等。规范热词使用、推广正面典型、直触现实问题,对于加强青年价值引领、纠正青年社会心态偏差、 构建青年正向社会心态具有重要意义。 Annual hot words have a summarizing and predictive role, and are an important dimension for examining the social mentality of young people. The hot words of 2023 reflect that contemporary youth are generally concerned about the national social development trend and cutting-edge technological trends, and their digital and technological literacy has generally improved; Having a love for life and a positive and optimistic attitude; Having a certain level of self-regulation ability. At the same time, the new consumption concepts that have emerged among young people in the post pandemic era convey positive psychological changes. However, some negative hot words also expose the social mentality bias of young people, who express powerlessness and anxiety towards the current situation, face difficulties in social isolation and labeling, are disturbed by blind obedience psychology, and the use of some negative hot words exposes negative venting tendencies. Standardizing the use of hot words, promoting positive examples, and directly addressing real-life issues are of great significance for strengthening the guidance of youth values, correcting deviations in youth social attitudes, and building positive social attitudes among young people.
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Kuikui Jiang,Ruoxi Hong,Wen Xia,Qianyi Lu,Liang Li,Jianhao Huang,Yanxia Shi,Zhongyu Yuan,Qiufan Zheng,Xin An,Cong Xue,Jiajia Huang,Xiwen Bi,Meiting Chen,Jingmin Zhang,Fei Xu,Shusen Wang 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2
Purpose This study aims to evaluate the efficacy and safety of a new combination treatment of vinorelbine and pyrotinib in human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) and provide higher level evidence for clinical practice. Materials and Methods This was a prospective, single-arm, phase 2 trial conducted at three institutions in China. Patients with HER2-positive MBC, who had previously been treated with trastuzumab plus a taxane or trastuzumab plus pertuzumab combined with a chemotherapeutic agent, were enrolled between March 2020 and December 2021. All patients received pyrotinib 400 mg orally once daily plus vinorelbine 25 mg/m2 intravenously or 60-80 mg/m2 orally on day 1 and day 8 of 21-day cycle. The primary endpoint was progression-free survival (PFS), and the secondary endpoints included the objective response rate (ORR), disease control rate (DCR), overall survival, and safety. Results A total of 39 patients were enrolled. All patients had been pretreated with trastuzumab and 23.1% (n=9) of them had accepted trastuzumab plus pertuzumab. The median follow-up time was 16.3 months (95% confidence interval [CI], 5.3 to 27.2), and the median PFS was 6.4 months (95% CI, 4.0 to 8.8). The ORR was 43.6% (95% CI, 27.8% to 60.4%) and the DCR was 84.6% (95% CI, 69.5% to 94.1%). The median PFS of patients with versus without prior pertuzumab treatment was 4.6 and 8.3 months (p=0.017). The most common grade 3/4 adverse events were diarrhea (28.2%), neutrophil count decreased (15.4%), white blood cell count decreased (7.7%), vomiting (5.1%), and anemia (2.6%). Conclusion Pyrotinib plus vinorelbine showed promising efficacy and tolerable toxicity as second-line treatment in patients with HER2-positive MBC.
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