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Patent and Anti-wrinkle Cosmetics
( Jinah Jang ) 대한화장품학회 2003 대한화장품학회지 Vol.29 No.2
In the 21st century, the development of cosmetics is led to pursue the high functionality of cosmetics with excellent effectiveness and safety. As Cosmetic Act took effect in 2000, functional cosmetics is provided in the law. As a result, the research and development of functional cosmetics has continually increased, and the number of patent applications in functional cosmetics has also rapidly increased as a plan for preoccupying in the functional cosmetics age. Now, the cosmetic industry has a great interest in developing anti-wrinkle cosmetics among functional cosmetics, because women's desire for having young resilient skin has increased since Korea entered an aging society thanks to the advanced medical technology. The patent application trends of anti-wrinkle cosmetics at home since 2000 particularly show the rapid increase in the applications in natural plant extracts. It may be because Korean consumers preference of vegetable cosmetics has resulted in the development of raw materials based on the traditional medicine. As for the existing preparation such as Retinoid or Ascorbic acid, the patent application itself will be an essential technical element in the future because patent applications are filed in the field of a preparation of cosmetics for stabilizing ingredients, reducing skin irritability or promoting absorbance, and in the field of cosmetic formulation technology. As there are many studies on the causes of skin wrinkles, it is expected that new raw materials of cosmetics can be developed due to new mechanisms, and that the number of patent applications in new technologies will increase due to a change in the thought of cosmetics accompanied by the integration of cosmetics with biotechnology using Genetic Engineering, including the practical application of the medicine previously used far treating skin diseases to an anti-wrinkle agent and the mass production of active ingredients of cosmetics.
Extracellular Matrix-derived Printable Biomaterials for Engineering Physiomimetic Human Tissues
Jinah JANG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
3D bioprinting is a pioneering technology to facilitate the recapitulation of unique features of complex human tissues and organs with high process flexibility and versatility. Bioinks, combinations of printable hydrogel and cells, can be utilized to create 3D cell-printed constructs. The bioactive cues of bioinks directly trigger cells to induce tissue morphogenesis and improve maturation process. Among the various printable hydrogels, the tissue- and organ-specific decellularized extracellular matrix (dECM) can exert synergistic effects in supporting various cells at any component by facilitating specific physiological properties. Recently, the controlling matrix stiffness has been demonstrated to have profound effect on regulating cancer cell behavior. In addition, the replicates created by printing cell-laden dECM hydrogels can provide the multi-drug high-throughput testing platform. Combined with mimicking pathophysiological reaction in the printed tissue models, printed organoids and human tissues could serve as an enabling platform for studying complex physiology in tissue and organ contexts of individuals.
Jang, Jinah,Cho, Dong-Woo Pioneer Bioscience Pub. Co 2017 Journal of thoracic disease Vol.9 No.2
<P>The ultimate goal of biomedical research is to understand human diseases and to determine improved therapeutic approaches based on scientific evidence. So far, many researchers have suggested new therapeutic targets and drugs by examining cells or genetically modified transgenic animals as candidates.</P>
Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics
Jang, Jinah,Park, Ju Young,Gao, Ge,Cho, Dong-Woo Elsevier 2018 Biomaterials Vol.156 No.-
<P><B>Abstract</B></P> <P>Building human tissues via 3D cell printing technology has received particular attention due to its process flexibility and versatility. This technology enables the recapitulation of unique features of human tissues and the all-in-one manufacturing process through the design of smart and advanced biomaterials and proper polymerization techniques. For the optimal engineering of tissues, a higher-order assembly of physiological components, including cells, biomaterials, and biomolecules, should meet the critical requirements for tissue morphogenesis and vascularization. The convergence of 3D cell printing with a microfluidic approach has led to a significant leap in the vascularization of engineering tissues. In addition, recent cutting-edge technology in stem cells and genetic engineering can potentially be adapted to the 3D tissue fabrication technique, and it has great potential to shift the paradigm of disease modeling and the study of unknown disease mechanisms required for precision medicine. This review gives an overview of recent developments in 3D cell printing and bioinks and provides technical requirements for engineering human tissues. Finally, we propose suggestions on the development of next-generation therapeutics and diagnostics.</P>