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Jihoon Shin,Shinae Park,Jung‑Shin Lee,Eun‑Jin Lee,Hong‑Duk Youn 한국유전학회 2020 Genes & Genomics Vol.42 No.3
Background Streptomyces seoulensis has contributed to the discovery and initiation of extensive research into nickel superoxide dismutase (NiSOD), a unique type of superoxide dismutase found in actinomycetes. Still so far, there is no information about whole genome sequence of this strain. Objective To investigate complete genome sequence and perform bioinformatic analyses for genomic functions related with nickel-associated genes. Methods DNA was extracted using the Wizard Genomic DNA Purification Kit then sequenced using a Pacific Biosciences SMRT cell 8Pac V3 DNA Polymerase Binding Kit P6 with the PacBiov2 RSII platform. We assembled the PacBio longreads with the HGAP3 pipeline. Results We obtained complete genome sequence of S. seoulensis, which comprises a 6,339,363 bp linear chromosome. While analyzing the genome to annotate the genomic function, we discovered the nickel-associated genes. We observed that the sodN gene encoding for NiSOD is located adjacent to the sodX gene, which encodes for the nickel-type superoxide dismutase maturation protease. In addition, several nickel-associated genes and gene clusters-nickel-responsive regulator, nickel uptake transporter, nickel–iron [NiFe]-hydrogenase and other putative genes were also detected. Strain specific genes were discovered through a comparative analysis of S. coelicolor and S. griseus. Further bioinformatic analyses revealed that this strain encodes at least 22 putative biosynthetic gene clusters, thereby implying that S. seoulensis has the potential to produce novel bioactive compounds. Conclusion We annotated the genome and determined nickel-associated genes and gene clusters and discovered biosynthetic gene clusters for secondary metabolites implying that S. seoulensis produces novel types of bioactive compounds.
Hong Jihoon,Lee Sang Yub,Lim Jae-Kwang,Lee Jongmin,Park Jongmin,Cha Jung Guen,Lee Hui Joong,Kim Donghyeon 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.8
Objective: To evaluate the feasibility of single-shot whole thoracic time-resolved MR angiography (TR-MRA) to identify the feeding arteries of pulmonary arteriovenous malformations (PAVMs) and reperfusion of the lesion after embolization in patients with multiple PAVMs. Materials and Methods: Nine patients (8 females and 1 male; age range, 23–65 years) with a total of 62 PAVMs who underwent percutaneous embolization for multiple PAVMs and were subsequently followed up using TR-MRA and CT obtained within 6 months from each other were retrospectively reviewed. All imaging analyses were performed by two independent readers blinded to clinical information. The visibility of the feeding arteries on maximum intensity projection (MIP) reconstruction and multiplanar reconstruction (MPR) TR-MRA images was evaluated by comparing them to CT as a reference. The accuracy of TR-MRA for diagnosing reperfusion of the PAVM after embolization was assessed in a subgroup with angiographic confirmation. The reliability between the readers in interpreting the TR-MRA results was analyzed using kappa (κ) statistics. Results: Feeding arteries were visible on the original MIP images of TR-MRA in 82.3% (51/62) and 85.5% (53/62) of readers 1 and 2, respectively. Using the MPR, the rates increased to 93.5% (58/62) and 95.2% (59/62), respectively (κ = 0.760 and 0.792, respectively). Factors for invisibility were the course of feeding arteries in the anteroposterior plane, proximity to large enhancing vessels, adjacency to the chest wall, pulsation of the heart, and small feeding arteries. Thirty-seven PAVMs in five patients had angiographic confirmation of reperfusion status after embolization (32 occlusions and 5 reperfusions). TR-MRA showed 100% (5/5) sensitivity and 100% (32/32, including three cases in which the feeding arteries were not visible on TR-MRA) specificity for both readers. Conclusion: Single-shot whole thoracic TR-MRA with MPR showed good visibility of the feeding arteries of PAVMs and high accuracy in diagnosing reperfusion after embolization. Single-shot whole thoracic TR-MRA may be a feasible method for the follow-up of patients with multiple PAVMs.
Hong Jihoon,Park C. Hyung Keun,Kim Harin,Hong Youjin,Ahn Junseok,Jun Jin Yong,Park Jangho,Kim Jeong Hye,Bang Young Rong,Chung Seockhoon 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.4
Objective We aimed to explore whether nursing professionals’ psychological states affect their grief response for a patient’s death in the coronavirus disease-2019 (COVID-19) inpatients’ ward.Methods Survey was conducted among frontline nursing professionals working in COVID-19 inpatients wards at three tertiary-level affiliated hospitals of the University of Ulsan during April 7–26, 2022. Participants’ information such as age, years of employment, or marital status were collected, and their responses to rating scales including Pandemic Grief Scale (PGS) for healthcare workers, Stress and Anxiety to Viral Epidemics-9 items (SAVE-9), Patient Health Questionnaire-9 (PHQ-9), Loneliness and Social Isolation Scale, and Insomnia Severity Scale (ISI) were collected.Results All 251 responses were analyzed. We observed that 34% reportedly suffered from depression. The linear regression analysis showed that a high PGS score was expected by high SAVE-9 (β=0.12, p=0.040), high PHQ-9 (β=0.25, p<0.001), high loneliness (β=0.17, p=0.006), and high ISI score (β=0.16, p=0.006, F=20.05, p<0.001). The mediation analysis showed that the depression of nursing professionals directly influenced their pandemic grief reaction, and their work-related stress and viral anxiety, insomnia severity, and loneliness partially mediated the association.Conclusion We confirm that frontline nursing professionals’ depression directly influenced their grief reaction, and their work-related stress and viral anxiety, insomnia severity, and loneliness partially mediated the association. We hope to establish a psychological and social support system for the mental health of nurses working in the COVID-19 wards.
Jihoon Hong,Sang Kyu Park,Sangho Roh KOREAN ACADAMY OF ORAL BIOLOGY 2010 International Journal of Oral Biology Vol.35 No.4
Cells that have endogenous multipotent properties can be used as a starting source for the generation of induced pluripotent cells (iPSC). In addition, small molecules associated with epigenetic reprogramming are also widely used to enhance the multi- or pluripotency of such cells. Skinderived precursor cells (SKPs) are multipotent, sphereforming and embryonic neural crest-related precursor cells. These cells can be isolated from a juvenile or adult mammalian dermis. SKPs are also an efficient starting cell source for reprogramming and the generation of iPSCs because of the high expression levels of Sox2 and Klf4 in these cells as well as their endogenous multipotency. In this study, valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, was tested in the generation of iPSCs as a potential enhancer of the reprogramming potential of SKPs. SKPs were isolated from the back skins of 5-6 week old C57BL/6 X DBA/2 F1 mice. After passage 3, the SKPs was treated with 2 mM of VPA and the quantitative real time RT-PCR was performed to quantify the expression of Oct4 and Klf4 (pluripotency specific genes), and Snai2 and Ngfr (neural crest specific genes). The results show that Oct4 and Klf4 expression was decreased by VPA treatment. However, there were no significant changes in neural crest specific gene expression following VPA treatment. Hence, although VPA is one of the most potent of the HDAC inhibitors, it does not enhance the reprogramming of multipotent skin precursor cells in mice.
Jihoon Hong,Gab Chul Kim,Jung Guen Cha,Jongmin Park,Byunggeon Park,Seo Young Park,Sang Un Kim 대한영상의학회 2024 대한영상의학회지 Vol.85 No.3
Afferent loop syndrome (ALS) is a rare complication of gastrectomies and gastrointestinal reconstruction. This can predispose patients to fatal conditions, such as cholangitis, pancreatitis, and duodenal perforation with peritonitis. Therefore, emergency decompression is necessary to prevent these complications. Herein, we report two cases in which transcholecystic duodenal drainage, an alternative decompression treatment, was performed in ALS patients without bile duct dilatation. Two patients who underwent distal gastrectomy with Billroth II anastomosis sought consultation in an emergency department for epigastric pain and vomiting. On CT, ALS with acute pancreatitis was diagnosed. However, biliary access could not be achieved because of the absence of bile duct dilatation. To overcome this problem, a duodenal drainage catheter was placed to decompress the afferent loop after traversing the cystic duct via a transcholecystic approach. The patients were discharged without additional surgical treatment 2 weeks and 1 month after drainage.
공간계량 방법론을 활용한 유럽의 전력수출입 결정요인 분석
홍원준 ( Won Jun Hong ),이지훈 ( Jihoon Lee ),노주만 ( Jooman Noh ),조홍종 ( Hong Chong Cho ) 한국환경경제학회·한국자원경제학회 2021 자원·환경경제연구 Vol.30 No.3
본 연구에서는 패널 공간더빈모형을 활용하여 유럽연합 회원국 26개 국가의 전력수출입 결정요인을 밝히는 것을 주요 목적으로 하며, 특히 전원별 발전량을 중심으로 설명하고자 한다. 이때 공간더빈모형을 활용함에 있어 단순히 인접기준 혹은 거리에 의해 가중치를 부여하는 방식이 아닌 전력 계통이 연계된 국가 간의 교역 비중을 기준으로 공간가중치 행렬을 구성하고자 한다. 또한 유럽 국가들의 전력계통은 직간접적으로 연결되어 지리적으로 멀리 떨어진 국가들 사이의 상호작용이 가능하므로, 이를 가중치행렬에 반영한다. 이를 바탕으로 분석한 결과, 원자력발전은 수출에는 양의 효과, 수입에는 음의 효과를 미치며 풍력·태양광 발전량의 증가는 전력의 계통 불안정성을 높여 수출과 수입에 모두 양의 효과를 미치는 것으로 분석되었다. 현재 국내의 지리적 여건상 타국과의 전력교역은 어려운 실정이다. 따라서 본 연구의 결과는 국내 에너지믹스 정책에 있어 시사하는 바가 있으며, 이전에 사용되지 않던 방식의 가중치행렬을 이용한 패널 공간더빈모형을 통해 전력수출입 요인을 분석했다는 데 의의가 있다. The main purpose of this study is to identify the determinants of electricity import and export in 26 European Union countries using the Spatial durbin model(SDM). In particular, we would like to mainly explain it based on the amount of power generated by each energy source. Not just the usual way of constructing a weighting matrix based on contiguity, we adopt a weighting method based on the proportion of trade among countries with connected electricity systems. Moreover, the electricity systems of European countries are directly and indirectly connected, which is reflected in the weighting matrix. According to the results, nuclear power has a positive effect on exports and a negative effect on imports, and an increase in wind and solar power has a positive effect on both exports and imports by increasing power system instability. While Korea is unable to trade electricity due to geopolitical conditions, the results of this study are expected to provide implications for energy policies.