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Jiayao Wang,Jianfeng Wang,Yanqiu Zhao,Yue Li,Xiaohong Zhan 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5
The present investigation aims at the thermal conditions for the TA15 titanium alloy laser welded bottom-locking joint. Bottom-locking featured specimens under three welding speeds were manufactured to study the grain morphology and tensileproperties. Finite element computation based on temperature field simulation was conducted in order to shed more light on themicrostructure characteristics of the bottom-locking joint. The results indicate a significant influence of the welding speed onthe thermal cycle, microstructure evolution and tensile performance. As the welding speed increases, the width of weld zone(WZ) is decreased significantly. At the same time, the columnar crystal features a coarser shape and its growth cross regionat the bottom of WZ becomes smaller with the increasing welding speed. Besides, the size of martensite decreases with theincreasing of welding speed. With the support of both numerical and experimental results, complex microstructure evolutionmechanisms were revealed involving thermal cycle related to the welding speed. In addition, the laser welded bottom-lockingjoint of TA15 titanium alloy is even fractured at the base metal, which exhibits the comparable tensile properties. The EDSresults illustrate the inevitable burning losses of stabilization element during the welding process. All these mechanisms areassociated with the bottom-locking joint arrangement and the welding speed-induced thermal cycle.
A review of the current in-situ fouling control strategies in MBR: Biological versus physicochemical
Qiang Liu,Jiayao Ren,Yongsheng Lu,Xiaolei Zhang,Felicity A. Roddick,Linhua Fan,Yufei Wang,Huarong Yu,Ping Yao 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
Fouling in membrane bioreactors (MBR) is a bottleneck problem limiting their application. In-situfouling control strategies have been continuously developed for decades, and can be mainlycategorized as biological and physicochemical approaches. However, the mechanisms and performanceof these methods as well as their application prospects have not been thoroughly discussed andcompared in a systematic manner. This study was aimed at providing a detailed review on the variousin-situ biological and physicochemical methods in terms of fouling control performance, foulingreduction mechanisms and practicability. This involves a comparison of the popular biological controlstrategies including quorum quenching (QQ)) and physicochemical approaches such as NaClObackflushing, hybrid electrochemical MBR and anti-biofouling membrane development, with theanalysis of their potential, existing issues and practicality in full-scale applications. Future work is alsorecommended for developing more sustainable and more widely applicable MBR fouling controlstrategies.
( Jia Yao ),( Yaqiu Ji ),( Tian Liu ),( Jinjia Bai ),( Han Wang ),( Ruoyu Yao ),( Juan Wang ),( Xiaoshuang Zhou ) 대한소화기기능성질환·운동학회 2024 Gut and Liver Vol.18 No.3
Background/Aims: The occurrence and development of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is closely related to the immune pathway. We explored the heterogeneity of peripheral blood T cell subsets and the characteristics of exhausted T lymphocytes, in an attempt to identify potential therapeutic target molecules for immune dysfunction in ACLF patients. Methods: A total of 83,577 T cells from HBV-ACLF patients and healthy controls were screened for heterogeneity by single-cell RNA sequencing. In addition, exhausted T-lymphocyte subsets were screened to analyze their gene expression profiles, and their developmental trajectories were investigated. Subsequently, the expression of exhausted T cells and their capacity in secreting cytokines (interleukin 2, interferon γ, and tumor necrosis factor α) were validated by flow cytometry. Results: A total of eight stable clusters were identified, among which CD4<sup>+</sup> TIGIT<sup>+</sup> subset and CD8<sup>+</sup> LAG-3<sup>+</sup> subset, with high expression of exhaust genes, were significantly higher in the HBV-ACLF patients than in normal controls. As shown by pseudotime analysis, T cells experienced a transition from naïve T cells to effector T cells and then exhausted T cells. Flow cytometry confirmed that the CD4<sup>+</sup>TIGIT<sup>+</sup> subset and CD8<sup>+</sup>LAG-3<sup>+</sup> subset in the peripheral blood of the ACLF patients were significantly higher than those in the healthy controls. Moreover, in vitro cultured CD8<sup>+</sup>LAG-3<sup>+</sup> T cells were significantly fewer capable of secreting cytokines than CD8<sup>+</sup>LAG-3<sup>-</sup> subset. Conclusions: Peripheral blood T cells are heterogeneous in HBV-ACLF. The exhausted T cells markedly increase during the pathogenesis of ACLF, suggesting that T-cell exhaustion is involved in the immune dysfunction of HBV-ACLF patients. (Gut Liver 2024;18:520-530)
Jia, Yao,Hu, Ting,Hang, Chuan-Ying,Yang, Ru,Li, Xiong,Chen, Zhi-Lan,Mei, Ye-Dong,Zhang, Qing-Hua,Huang, Ke-Cheng,Xiang, Qun-Ying,Pan, Xiu-Yu,Yan, Yu-Ting,Wang, Xiao-Li,Wang, Shao-Shuai,Hang, Zhou,Tang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Purpose: To investigate the diet of patients with cervical cancer and precancerosis in the Wufeng area, a high-incidence region in China. Methods: In the case group, 104 patients diagnosed with cervical cancer or cervical intraepithelial neoplasias (CINII/III) were recruited from the Wufeng area. Nine hundred thirty-six healthy women were selected from the same area as the matched controls. A questionnaire, which included questions about general lifestyle conditions, smoking and alcohol status, source of drinking water, green tea intake, and diet in the past year, was presented to all participants. Results: Green tea intake (P=0.022, OR=0.551, 95% CI=0.330-0.919) and vegetable intake (P=0.035, OR=0.896, 95% CI=0.809-0.993) were identified as protective factors against cervical cancer or CINII/III. There was no indication of any associations of other lifestyle factors (smoking status, alcohol status, source of drinking water) or diet (intake of fruit, meat/egg/milk, soybean food, onion/garlic, staple food and pickled food) with cervical cancer. Conclusions: The results suggest that eating more fresh vegetables and drinking more green tea may help to reduce the risk of cervical cancer or CINII/III in people of the Wufeng area.