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Jiale Song,최정호,성재훈,임양이,박건영 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.9
Polyphyllin D (PD), an active component from a traditional medicinal herb Paris polyphylla, which has long been used for the treatment of cancer in Asian countries, has been found to hold significant antitumor activity in vivo or in vitro. However, there were few reports on the effects and underlying mechanism of PD on apoptosis in U87 human glioma cells. The present study was conducted to evaluate apoptotic induction of PD in U87 human glioma cells, and explore its underlying pathway. U87 glioma cells were cultured and treated with varied concentrations of PD (from 10- 8 to 10- 4 M). The inhibition of U87 glioma cell proliferation by PD was assessed by MTT assay. The apoptosis of U87 glioma cells was detected by flow cytometry, and western blot analysis was used to examine human B-cell leukemia/lymphoma 2 (Bcl-2), human Bcl-2 associated X protein (Bax), caspase-3, total-c-jun NH2-terminal kinase (t-JNK), and phosphorylation-JNK (p-JNK) protein expression in U87 human glioma cells. The treatment with PD for 24 h significantly inhibited the proliferation of U87 human glioma cells in a concentration-dependent manner. PD increased apoptosis and significantly upregulated the expression of Bax, caspase-3, and p-JNK associated with apoptosis, but downregulated antiapoptotic Bcl-2 expression in U87 human glioma cells. Our data provided evidences that PD induces apoptosis in U87 human glioma cells. This effect might be associated with the JNK pathway.
Antiobesity Effects of Bamboo Salt in C57BL/6 Mice
주재현,Jiale Song,박건영 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.6
Antiobesity effects of bamboo salt (BS) were evaluated compared with those of purified salt and solar salt by oral administration in a diet-induced obesity model using C57BL/6 mice. Compared with other salts, BS, especially nine times baked BS (BS-9Ⅹ), significantly reduced body weight, food efficiency ratio, and weights of epididymal adipose tissue and liver in high-fat diet–fed mice. Furthermore, BS suppressed the expression of adipogenic factors, such as CCAAT/enhancer binding protein alpha (C/EBPα), peroxisome proliferator-activated receptor gamma (PPARγ), and sterol regulatory elementbinding protein 1c (SREBP-1c). Therefore, BS may suppress obesity by downregulating adipogenesis.
김보경,Jiale Song,주재현,강순아,박건영 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.2
Anticancer effects of kimchi fermented for different times and containing added ingredients in HT-29 human colon carcinoma cells were studied. Optimally ripened kimchi showed higher anti-proliferation activities than fresh and over-ripened kimchi. Anticancer-ingredientsadded kimchi exhibited higher activities than standardizedrecipe kimchi in HT-29 cells. Optimally-ripened anticancer kimchi suppressed expression of Bcl-2 and promoted expression of Bax, caspase-9, and caspase-3 to promote apoptosis, and reduced mRNA expressions of proinflammatory factors, exhibiting the strongest anticancer effect. Fermentation and ingredients are important factors to increase in vitro anticancer functionalities.
Chemical Properties and In vivo Gastric Protective Effects of Bamboo Salt
Xin Zhao,Jiale Song,정옥상,임양이,박건영 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Bamboo salt chemical properties and in vivogastric protective effects were evaluated. Scanning electronmicroscopy revealed the diameter of 9× bamboo salt wasapproximately 5 μm, the smallest of all samples. The Ca,Mg, Fe, Mn, P, S, and K levels of bamboo salts werehigher than for common salts. X-ray diffraction and X-rayphotoelectron spectroscopy analyses showed bamboo saltshad a complex structure composed of NaCl, KCl, andMgCl2. Bamboo salt structure complexity increased withincreased baking times. Purified, solar, and 1× bamboo saltinhibited gastric injury by 19.3%, 28.0%, and 77.8% inSprague-Dawley (SD) rats, respectively. The 9× bamboosalt showed a high rate of gastric injury inhibition (98.7%). The effect of omeprazole was 99.3%. Bamboo saltsreduced gastric secretion and increased gastric juice pH byincreased mineral and phytochemical contents, and increasedantioxidant activities. Bamboo salt can be used as afunctional food to protect against gastric injury.
Antioxidation and Cancer Cell (HT-29) Antiproliferation Effects of Rubus coreanus Miquel Bamboo Salt
Xin Zhao,Jiale Song,Joug-Hynu Lee,So-Young Kim,박건영 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.4
Bamboo is used by Korean as an important medicinal material. It has many different medicinal efficacy from its stub, roots and leaves. Rubus coreanus Miquel (raspberry) is thought to contain compounds which are important towards having health benefits. Rubus coreanus Miquel bamboo salt sample was prepared and showed in vitro antioxidant, antimutagenic and anticancer effects in this study. The radical scavenging effect of Rubus coreanus Miquel bamboo salt on DPPH radical were tested. The Rubus coreanus Miquel bamboo salt sample revealed better scavenging activities on DPPH radical than the other salt samples at concentrations of 10 and 20%. Antimutagenic effects of Rubus coreanus Miquel Bamboo salt were investigated and compared with other salt samples. Though solar salt exhibited comutagenicty with MNNG, bamboo salt showed antimutagenicity against MNNG. The Rubus coreanus Miquel bamboo salt showed more increased antimutagenicity than the bamboo salt. MTT assay was carried out with the salts treated HT-29 cancer cells. The Rubus coreanus Miquel bamboo salt showed better anticancer activities (69%) than purple bamboo salt (44%) and solar salt (11%) at a concentration of 1%, and Rubus coreanus Miquel bamboo salt also exhibited better anticancer activities than other salt samples at the low concentration of 0.5% (p<0.05). The analysis of apoptosis related genes was carried out using RT-PCR to check the anticancer effect in the colon cancer cells and showed the same anticancer cancer effects as shown in MTT assay. From the experimental results, Rubus coreanus Miquel bamboo salt exhibited better health functional effects than common bamboo salts and solar salt. (Cancer Prev Res 15, 306-312,2010)