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Unripe Pear Extract Suppresses UVB-Induced Skin Photoaging in Hairless Mice and Keratinocytes
Jeongjin Park,김다경,Minhee Lee,박금덕,김수로,Yanxiu Jiang,Woojin Jun,김옥경,이정민 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Our study aimed to investigate whether unripe pear extract (UP) could provide protection against UVBinduceddamage to both mouse skin and keratinocytes. We observed that UVB exposure, a common contributor to skinphotoaging, led to wrinkle formation, skin dryness, and inflammation in mice. Nevertheless, these effects were mitigated inthe groups of UVB-irradiated mice treated with UP. Moreover, UP treatment at 400 lg/mL increased the antioxidant enzymeactivities (sodium dodecyl sulfate, 2.22-fold higher; catalase, 2.91-fold higher; GPx, 1.96-fold higher) along with sphingomyelin(1.58-fold higher) and hyaluronic acid (1.31-fold higher) levels in UVB-irradiated keratinocytes. In the keratinocytesirradiated with UVB, UP 400 lg/mL resulted in reduced cytokine production (TNF-a, 33.2%; IL-1b, 45.3%; IL-6, 33.4%) andthe expression of inflammatory pathway-related proteins. The findings indicate that UP has a direct protective effect on UVBirradiatedkeratinocytes and is also able to shield against photoaging induced by UVB. Hence, it is suggested that UP couldcontribute to improved skin health by averting skin photoaging.