http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Targeting mutant <i>KRAS</i> with CRISPR-Cas9 controls tumor growth
Kim, Wonjoo,Lee, Sangeun,Kim, Han Sang,Song, Minjung,Cha, Yong Hoon,Kim, Young-Hoon,Shin, Jeonghong,Lee, Eun-Seo,Joo, Yeonsoo,Song, Jae J.,Choi, Eun Ju,Choi, Jae W.,Lee, Jinu,Kang, Moonkyung,Yook, Jon Cold Spring Harbor Laboratory Press 2018 Genome Research Vol.28 No.3
<P>KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double-strand break, which enables editing of the relevant genes. Here, we harnessed CRISPR to specifically target mutant KRAS alleles in cancer cells. We screened guide RNAs using a reporter system and validated them in cancer cells after lentiviral delivery of Cas9 and guide RNA. The survival, proliferation, and tumorigenicity of cancer cells in vitro and the growth of tumors in vivo were determined after delivery of Cas9 and guide RNA. We identified guide RNAs that efficiently target mutant OAS without significant alterations of the wild-type allele. Doxycycline-inducible expression of this guide RNA in KRAS-mutant cancer cells transduced with a lentiviral vector encoding Cas9 disrupted the mutant KRAS gene, leading to inhibition of cancer cell proliferation both in vitro and in vivo. Intra-tumoral injection of lentivirus and adeno-associated virus expressing Cas9 and sgRNA suppressed tumor growth in vivo, albeit incompletely, in immunodeficient mice. Expression of Cas9 and the guide RNA in cells containing wild-type KIZAS did not alter cell survival or proliferation either in vitro and in vivo. Our study provides a proof-of-concept that CRISPR can be utilized to target driver mutations of cancers in vitro and in vivo.</P>
무인수상선의 자율운항을 위한 단안 카메라 기반의 근거리 선박 자동 탐지
박정홍(Jeonghong Park),한정욱(Jungwook Han),김진환(Jinwhan Kim),손남선(Nam-sun Son),김선영(Sun Young Kim) 제어로봇시스템학회 2017 제어·로봇·시스템학회 논문지 Vol.23 No.6
Automatic detection and tracking of nearby ships are important capabilities for the autonomous operation of unmanned surface vehicles (USVs). This study focuses on achieving such capabilities in the framework of vision-based perception and sensor fusion. Reliable detection and tracking processes using a monocular camera are designed to automatically detect maneuvering targets with no prior information on the motion of targets. For a reliable trajectory estimation in low observability situations, the proposed vision-based approach uses bearing information in both the horizontal and vertical directions. In addition, the measurement by an onboard lidar is integrated into the vision-based tracking filter when the targets are in close range. The performance of the proposed method was assessed by field experiment data obtained in a real-sea environment to show the feasibility of the developed algorithms for the autonomous navigation of USVs.
Broadcasting based on Selfish Probability in Mobile Ad Hoc Networks
Jaesoo Kim,Jeonghong Kim,Dharma P. Agrawal 한국멀티미디어학회 2006 한국멀티미디어학회 국제학술대회 Vol.2006 No.-
In a mobile ad hoc network (MANETs), broadcasting is extensively used in route discovery, address resolution, and many other network services. The efficiency of broadcasting protocol can dramatically affect the performance of the entire network. In a MANET, we categorize mobile hosts into normal nodes and selfish nodes. Normal nodes forward packets for other nodes while selfish nodes do not. In this paper, we propose broadcasting mechanism based on selfish probability MANETs. The advantage of using selfish nodes is that the total rebroadcast traffic can be reduced. The disadvantage, in theory, is that we may miss the optimal route and suffer from a low delivery rate. Using this method, we can reduce routing cost by minimizing the number of rebroadcasts in route discovery phase, while achieving higher delivery rate due to the reduction of rebroadcast traffic, which leads to fewer collisions. We compare our approach with AODV Simulation results show that our approach outperforms the AODV protocol minimizing the number of rebroadcasts.
클라이언트 - 서버 환경에서 슬롯 재사용 분산 - 큐 이중 - 버스의 공정성 제어를 위한 빌림과 반환 방식
김정홍(JeongHong Kim),권오석(OhSeok Kwon) 한국정보과학회 2001 정보과학회논문지 : 정보통신 Vol.28 No.3
본 논문에서는 클라이언트-서버 환경에서 DQDB-SR 네트워크 대역폭을 모든 스테이션에게 공평하게 할당하기 위한 새로운 방식을 제안하였다. 제안한 방식은 클라이언트-서버 부하 패턴의 특성을 따르는 접근 임계값과 대역폭 빌림과 반환 방식을 사용하여 DQDB-SR에게 공평한 대역폭 제어 기능을 제공한다. 이를 구현하기 위해 DQDB-SR의 처리 용량을 최대로 하는 소거 노드의 위치와 접근 임계값을 구하였다. 제안한 방식이 과부하시 클라이언트-서버 부하 패턴에 대하여 네트워크 처리 능력을 저하시키지 않고, 패킷 전송 성공률과 평균 패킷 전달 지연 시간에 있어 다른 공정성 제어 방식들 보다 우수하다는 것을 시뮬레이션 결과를 통하여 확인하였다 In this paper, a new fairness control method is proposed to distribute DQDB-SR (Distributed-Queue Dual-Bus with Slot Reuse) network bandwidth fairly to all stations on client-server environments. By using an access limit that follows a characteristic of client-server load patterns and a bandwidth borrowing and returning mechanism, the proposed mechanism imparts fairness bandwidth control capability to DQDB-SR. To implement the proposed mechanism, we find the optimal placement of erasure nodes that maximizes network capacity for DQDB-SR, and calculate the access limit. At overload conditions, simulation results show that the proposed mechanism does not deteriorate network throughput, and outperforms other fairness control mechanisms in a success rate and an average packet transfer delay.
김성진(Seongjin Kim),손권(Kwoo Son),박정홍(Jeonghong Park),김광훈(Kwanghoon Kim) 한국자동차공학회 2002 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2002 No.5_2
A Korean dummy was developed to determine accelerations of specific dummy bodies in frontal and lateral crashes. This study selects 32 parameters for Korean males from the geometric and physical data generated by GEBOD. and then separates each hand from lower arms. Simulations for validation were performed using Korean dummy for frontal and lateral crashes developed for the use of MADYMO.<br/> Head and thorax accelerations of Korean dummy in frontal crash tests were found to be higher than those of Hybrid Ⅲ on the whole. T1 lateral acceleration of Korean dummy generally agreed the ISO requirement for a lateral impact dummy, but it failed to fall within the upper boundary of the requirement.