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( Yong Chul Lee ),( So Ri Kim ),( Kyung Sun Lee ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Myung Shin Jeon ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0
Bronchial asthma is a chronic inflammatory disorder of the airway accompanied by increased vascular permeability. Vascular endothelial growth factor (VEGF) is a potent stimulator of bronchial inflammation, airway remodeling, and physiologic dysre-gulation that augments antigen sensitization and T-helper type 2 cell (Th2)-mediated inflammation in allergic airway diseases. The p38 mitogen-activated protein kinase (MAPK) appears to play an important role in various pathophysiological responses and has been suggested to be involved in many processes considered critical to the inflammatory response and tissue remodeling. However, there are little data on the relationship between p38 MAPK signaling and VEGF expression in allergic airway disease. Using ovalbumin (OVA)-inhaled mice and a selective p38 MAPK inhibitor, SB 239063, the involvement of p38 MAPK in aller-gen-induced VEGF expression in the airway was evaluated. The increases of phosphorylation of p38 MAPK, VEGF protein expression, and vascular permeability in the lung after OVA inhalation were decreased substantially by the administration of SB 239063. In addition, SB 239063 significantly reduced the increase of Th2 cytokines and OVA-specific IgE. The inhibition of p38 MAPK or VEGF signaling prevented and also decreased the increases in the number of inflammatory cells and airway hyperresponsiveness in OVA-induced allergic airway disease. These results indicate that inhibition of p38 MAPK may attenuate allergen-induced airway inflammation and vascular leakage through modulation of VEGF expression in mice.
Perinatal Outcome Of Twin Reversed Arterial Perfusion Sequence: A Single Center`s Experience
( Mi Young Lee ),( Hye Sung Won ),( Kyung A Lee ),( Kyu Sang Kyeong ),( Eun Jin Jeon ),( Jae Yoon Shim ),( Pil Ryang Lee ),( Ahm Kim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.8
Objective To report our experience of using radiofrequency ablation (RFA) to treat fetuses diagnosed with twin reversed arterial perfusion (TRAP) sequence and to evaluate the perinatal outcome of pump twins. Methods Twenty-six fetuses diagnosed with the TRAP sequence were retrospectively analyzed between July 1998 and September 2011 at Asan Medical Center. Four were lost to follow-up after diagnosis and, therefore, were excluded from further evaluation. The perinatal outcomes of pump twins were evaluated by reviewing the medical records. Results Twenty-two fetuses were diagnosed with the TRAP sequence during the study period, including 15 monochorionic-diamniotic pregnancies and four monochorionic-monoamniotic pregnancies. Three patients had triplet pregnancies. The median gestational age at diagnosis was 17.4 weeks (range, 11.0 to 27.0 weeks). Of these 22 cases, in utero RFA was performed in 11 (50%), alcohol ablation in one (4.5%) and the remaining 10 (45.5%) underwent conservative management. The median gestational age at in utero intervention was 21.0 weeks (range, 17.6 to 25.0 weeks). The overall neonatal survival rate was 77% (17 of 22). The median gestational age at delivery was 37.3 weeks (range, 30.2 to 40.1 weeks). All of the surviving infants are doing well without any complications. Conclusion For fetuses with the TRAP sequence, proper in utero treatment with RFA enables to continue the pregnancy with a good prognosis.
이미영 ( Mi Young Lee ),( Hye Sung Won ),( Kyung A Lee ),( Kyu Sang Kyeong ),( Eun Jin Jeon ),( Jae Yoon Shim ),( Pil Ryang Lee ),( Ahm Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Objective: To report our experience of using radiofrequency ablation (RFA) to treat fetuses diagnosed with twin reversed arterial perfusion (TRAP) sequence and to evaluate the perinatal outcome of pump twins. Methods: Twenty-six fetuses diagnosed with the TRAP sequence were retrospectively analyzed between July 1998 and September 2011 at Asan Medical Center. Four were lost to follow-up after diagnosis and, therefore, were excluded from further evaluation. The perinatal outcomes of pump twins were evaluated by reviewing the medical records. Results: Twenty-two fetuses were diagnosed with the TRAP sequence during the study period, including 15 monochorionic-diamniotic pregnancies and four monochorionic-monoamniotic pregnancies. Three patients had triplet pregnancies. The median gestational age at diagnosis was 17.4 weeks (range, 11.0 to 27.0 weeks). Of these 22 cases, in utero RFA was performed in 11 (50%), alcohol ablation in one (4.5%) and the remaining 10 (45.5%) underwent conservative management. The median gestational age at in utero intervention was 21.0 weeks (range, 17.6 to 25.0 weeks). The overall neonatal survival rate was 77% (17 of 22). The median gestational age at delivery was 37.3 weeks (range, 30.2 to 40.1 weeks). All of the surviving infants are doing well without any complications. Conclusion: For fetuses with the TRAP sequence, proper in utero treatment with RFA enables to continue the pregnancy with a good prognosis.
A Numerical Study on Coal Devolatilization of Bituminous Coal Using CPD Model
Ryang Gyoon Kim(김량균),Byoung Hwa Lee(이병화),Chung Hwan Jeon(전창환),Young June Chang(장용준),Ju Hun Song(송주헌) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
The coal considerably is the energy resource which is important with the new remarking energy resource. The coal conversion has two processes which are coal devolatilization and char oxidation. Coal devolatilization is important because it describes up to 70% weight loss and has been shown that nitrogen contribute 60 to 80% of the total NOx produced. The chemical percolation devolatilization(CPD) model is used here to describe coal devolatilization. The model was developed to describe coal devolatilization behavior of rapidly heated coal based on characteristics of the chemical structure of the parent coal. This paper describes CPD model in detail and makes an analysis of Shenhua coal(bituminous) which is used calculated 13-C NMR(carbon - nuclear magnetic resonance).
Clausena anisata-mediated protection against lipopolysaccharide-induced acute lung injury in mice
JEON, CHAN-MI,SHIN, IN-SIK,SHIN, NA-RAE,HONG, JU-MI,KWON, OK-KYOUNG,KIM, JUNG-HEE,OH, SEI-RYANG,BACH, TRAN-THE,HAI, DO-VAN,QUANG, BUI-HONG,CHOI, SANG-HO,LEE, JOONGKU,MYUNG, PYUNG-KEUN,AHN, KYUNG-SEOP Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.37 No.4
<P>Clausena anisata (Willd.) Hook.f. ex Benth. (CA), which is widely used in traditional medicine, reportedly exerts antitumor, anti-inflammatory and other important therapeutic effects. The aim of the present study was to investigate the potential therapeutic effects of CA in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and in LPS-stimulated RAW 264.7 cells. Male C57BL/6 mice were administered treatments for 3 days by oral gavage. On day 3, the mice were instilled intranasally with LPS or PBS followed 3 h later by oral CA (30 mg/kg) or vehicle administration. In vitro, CA decreased nitric oxide (NO) production and pro-inflammatory cytokines, such as interleukin (IL)-6 and prostaglandin E2 (PGE(2)), in LPS-stimulated RAW 264.7 cells. CA also reduced the expression of pro-inflammatory mediators, such as cyclooxygenase-2. In vivo, CA administration significantly reduced inflammatory cell numbers in the bronchoalveolar lavage fluid (BALF) and suppressed pro-inflammatory cytokine levels, including tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-1 beta, as well as reactive oxygen species production in the BALF. CA also effectively reduced airway inflammation in mouse lung tissue of an LPS-induced ALI mouse model, in addition to decreasing inhibitor kappa B (I kappa B) and nuclear factor-kappa B (NF-kappa B) p65 phosphorylation. Taken together, the findings demonstrated that CA inhibited inflammatory responses in a mouse model of LPS-induced ALI and in LPS-stimulated RAW 264.7 cells. Thus, CA is a potential candidate for development as an adjunctive treatment for inflammatory disorders, such as ALI.</P>
고교 레슬링선수의 무산소성 파워 및 측정방법의 타당도에 관한 사례 연구
전해섭,윤재량,정동군,이희동,이정근 韓國體育大學校 1995 論文集 Vol.18 No.-
1) Anaerobic power by jump reach test record was not significant difference statistically between Free-style and Grecoroman-style player. 2) Anaerobic power by 50m Allout-running was not significant difference statistically between free-style player and Grecoroman-style player. 3) Anaerobic power by Lewis-nomogram After measure jump reach test record and weight was not significant difference statistically between Free-style player and Grecoroman-style player.. 4) Anaerobic maximal, Anaerobic mean power and total power were not significant difference statistically between Free-style and Grecoroman-style player. 5) Wingate test measurement method can substitution for Anaerobic power measurement method by Lewis-nomogram.
Lee, Dae-Sang,Suh, Gee Young,Ryu, Jeong-Am,Chung, Chi Ryang,Yang, Jeong Hoon,Park, Chi-Min,Jeon, Kyeongman by 2015 by the Society of Critical Care Medicine a 2015 Critical care medicine Vol.43 No.7
OBJECTIVES:: The objective of this observational study was to evaluate whether early intervention was associated with improved long-term outcomes in critically ill patients with cancer. DESIGN:: Retrospective analysis with prospectively collected data. SETTING:: A university-affiliated, tertiary referral hospital. PATIENTS:: Consecutive critically ill cancer patients who were managed by a medical emergency team before ICU admission between January 2010 and December 2012. INTERVENTIONS:: None. MEASUREMENTS AND MAIN RESULTS:: During the study period, 525 critically ill cancer patients were admitted to the ICU with respiratory failure (41.7%) and severe sepsis or septic shock (40.6%) following medical intervention by a medical emergency team. Of 356 ICU survivors, 161 (45.2%) received additional treatment for cancer after ICU discharge. Mortality was 66.1% at 6 months and 72.8% at 1 year. Median time from physiological derangement to intervention before ICU admission was significantly shorter in 1-year survivors (1.3 hr; interquartile range, 0.5–4.8 hr) than it was in nonsurvivors (2.9 hr; interquartile range, 0.8–9.6 hr) (p< 0.001). Additionally, the early intervention (≤ 1.5 hr) group had a lower 30-day mortality rate than the late intervention (> 1.5 hr) group (29.0% vs 55.3%; p < 0.001) and a similar difference in mortality rate was observed up to 1 year. Other factors associated with 1-year mortality were illness severity, performance status, malignancy status, presence of more than three abnormal physiological variables, time from derangement to ICU admission, and the need for mechanical ventilation. Even after adjusting for potential confounding factors, early intervention was significantly associated with 1-year mortality (adjusted hazard ratio, 0.456; 95% CI, 0.348–0.597; p < 0.001). CONCLUSION:: Early intervention for clinical derangement on general wards was significantly associated with long-term outcomes in critically ill cancer patients.
CPD 모델을 활용한 석탄 탈휘발화 과정 중 탄종에 따른 HCN 배출에 관한 수치해석적 연구
김량균(Ryang Gyoon Kim),이병화(Byoung Hwa Lee),전충환(Chung-Hwan Jeon),송주헌(Ju Hun Song),장영준(Young June Chang) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
Coal is the energy resource which is important with the new remarking energy resource. Coal combustion produces more NOx per unit of energy than any other major combustion technology. Pollutant emission associated with coal combustion will have a huge impact on the environment. Coal conversion has three processes which are dry, coal devolatilization and char oxidation. Coal devolatilization progress is important because it has been shown that HCN which is converted from volatile N contributes 60 to 80% of the total NOx produced. This paper describes mass release of Char, Tar, Gas by CPD model about Roto middle coal (Sub-bituminous) and Anglo coal (Bituminous). CPD model also predicts mass release of HCN about the two coals. The results show that HCN increases as a function of decreasing the ratio of FC/VM.
CPD 모델을 이용한 국내수입탄 성상에 따른 탈휘발 특성에 관한 실험 및 해석적 연구
김량균(Ryang Gyoon Kim),이병화(Byoung Hwa Lee),전충환(Chung Hwan Jeon),송주헌(Ju Hun Song),장영준(Young June Chang),Thomas H. Fletcher 대한기계학회 2009 大韓機械學會論文集B Vol.33 No.8
Coal is the energy resource which is important with the new remarking energy resource. Coal combustion produces more NOx per unit of energy than any other major combustion technology. Pollutant emission associated with coal combustion will have a huge impact on the environment. Coal conversion has three processes which are drying, coal devolatilization and char oxidation. Coal devolatilization process is important because it has been shown that HCN which is converted from volatile N contributes 60 to 80% of the total NOx produced. This paper addresses mass release behavior of char, tar, gas and HCN in an experiment of Laminar Flow Reactor with two coals such as Roto middle coal (Sub-bituminous) and Anglo coal (Bituminous). The experiment is compared with the data predicted by CPD model for mass release of HCN about Roto south, Indominco, Weris creek and China orch coals. The results show that HCN increases as a function of decreasing the ratio of fixed carbon(FC)/ volatile matter(VM of the coals contain.)