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Type 2 Diabetes Mellitus Increases Peritonsillar Abscess Susceptibility: Real-World Evidence
Ching-Lung Wu,Ming-Shao Tsai,Ta-Jen Lee,Yun-Ting Wang,Chia-Yen Liu,Yao-Hsu Yang,Yao-Te Tsai,Cheng-Ming Hsu,Ching-Yuan Wu,Pey-Jium Chang,Geng-He Chang 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.3
Objectives. Type 2 diabetes mellitus (T2DM) is a risk factor for deep neck infection (DNI) and leads to complications and poor outcomes. Our study aimed to investigate the risk, prognosis, and complications of peritonsillar abscess (PTA) in patients with T2DM. Methods. We extracted data of patients newly diagnosed as having T2DM between January 2000 and December 2011 from Taiwan’s National Health Insurance Research Database. These patients were matched with patients without T2DM, and PTA incidence was compared between both cohorts. Results. In total, 67,852 patients with and 135,704 patients without T2DM were enrolled. PTA incidence was significantly higher in patients with T2DM (incidence rate ratio, 1.91; P<0.001); moreover, PTA incidence was higher at 1 to 5 years after T2DM diagnosis than at <1 and >5 years after T2DM diagnosis. Cox regression analysis showed that patients with T2DM had an approximately 2-fold higher PTA risk (adjusted hazard ratio [aHR]: 1.89, P<0.001). Patients with a higher adapted Diabetes Complications Severity Index (aDCSI) had higher PTA risk than those with a lower aDCSI (aHRs: 2.17 for aDCSI ≥1, P=0.006 and 1.81 for aDCSI=0, P=0.002). T2DM patients with a high aDCSI (≥1) had a nonsignificantly longer hospitalization duration and a higher rate of DNI complications than did those with a low aDCSI (=0). Conclusion. In patients with T2DM, PTA incidence was relatively high, and it increased with T2DM severity. Moreover, T2DM patients should be particularly careful about PTA within 1 to 5 years after the diagnosis, and physicians should keep in mind that the prognosis of PTA was correlated with T2DM severity.
Design of Vector Register Architecture in DSP Processor for Efficient Multimedia Processing
Wu, Chou-Pin,Wu, Jen-Ming The Institute of Electronics and Information Engin 2007 Journal of semiconductor technology and science Vol.7 No.4
In this paper, we present an efficient instruction set architecture using vector register file hardware to accelerate operation of general matrix-vector operations in DSP microprocessor. The technique enables in-situ row-access as well as column access to the register files. It can reduce the number of memory access significantly. The technique is especially useful for block-based video signal processing kernels such as FFT/IFFT, DCT/IDCT, and two-dimensional filtering. We have applied the new instruction set architecture to in-loop deblocking filter processing in H.264 decoder. Performance comparisons show that the required load/store operations for the in-loop deblocking filter can be reduced about 42%. The architecture would improve the processing speed, and code density in DSP microprocessor especially for video signal processing substantially.
Innate Immune Response of NNV Infection in Fish and Its Disease Prevention
Lu, Ming-Wei,Wu, Jen-Leih The Korean Society for Marine Biotechnology 2007 한국해양바이오학회지 Vol.2 No.3
The innate immune response which is seen as the initial defense mechanism induced upon foreign invasion has been well documented in higher vertebrates. This has also been observed in fish infected with NNV. However, the fish immune system based on fully established genome project has not been fully elucidated. Therefore, in this review, we hope to correlate NNV infection in fish that has devastated the aquaculture industry, to its host immune system. Further, we discuss the potential preventive measures in overcoming the widespread of this neurodisease.
Jeng, Jen-Eing,Wu, Hui-Fang,Tsai, Meng-Feng,Tsai, Huey-Ru,Chuang, Lea-Yea,Lin, Zu-Yau,Hsieh, Min-Yuh,Chen, Shinn-Chern,Chuang, Wan-Lung,Wang, Liang-Yen,Yu, Ming-Lung,Dai, Chia-Yen,Tsai, Jung-Fa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
To assess the contribution of tumor necrosis factor $(TNF){\beta}$ +252 polymorphisms to risk and prognosis of hepatocellular carcinoma (HCC), we enrolled 150 pairs of sex- and age-matched patients with HCC, patients with cirrhosis alone, and unrelated healthy controls. $TNF{\beta}$ +252 genotypes were determined by polymerase chain reaction with restriction fragment length polymorphism. Multivariate analysis indicated that $TNF{\beta}$ G/G genotype [odds ratio (OR), 3.64; 95%CI, 1.49-8.91], hepatitis B surface antigen (OR, 16.38; 95%CI, 8.30-32.33), and antibodies to hepatitis C virus (HCV) (OR, 39.11; 95%CI, 14.83-103.14) were independent risk factors for HCC. There was an additive interaction between $TNF{\beta}$ G/G genotype and chronic hepatitis B virus (HBV)/HCV infection (synergy index=1.15). Multivariate analysis indicated that factors associated with $TNF{\beta}$ G/G genotype included cirrhosis with Child-Pugh C (OR, 4.06; 95%CI, 1.34-12.29), thrombocytopenia (OR, 6.55; 95%CI, 1.46-29.43), and higher serum ${\alpha}$-fetoprotein concentration (OR, 2.53; 95%CI, 1.14-5.62). Patients with $TNF{\beta}$ G/G genotype had poor cumulative survival (p=0.005). Cox proportional hazard model indicated that $TNF{\beta}$ G/G genotype was a biomarker for poor HCC survival (hazard ratio, 1.70; 95%CI, 1.07-2.69). In conclusion, there are independent and additive effects between $TNF{\beta}$ G/G genotype and chronic HBV/HCV infection on risk for HCC. It is a biomarker for poor HCC survival. Carriage of this genotype correlates with disease severity and advanced hepatic fibrosis, which may contribute to a higher risk and poor survival of HCC. Chronic HBV/HCV infected subjects with this genotype should receive more intensive surveillance for early detection of HCC.
Design of Vector Register Architecture in DSP Processor for Efficient Multimedia Processing
Chou-Pin Wu,Jen-Ming Wu 대한전자공학회 2007 Journal of semiconductor technology and science Vol.7 No.4
In this paper, we present an efficient instruction set architecture using vector register file hardware to accelerate operation of general matrixvector operations in DSP microprocessor. The technique enables in-situ row-access as well as column access to the register files. It can reduce the number of memory access significantly. The technique is especially useful for block-based video signal processing kernels such as FFT/IFFT, DCT/IDCT, and two-dimensional filtering. We have applied the new instruction set architecture to in-loop deblocking filter processing in H.264 decoder. Performance comparisons show that the required load/store operations for the in-loop deblocking filter can be reduced about 42%. The architecture would improve the processing speed, and code density in DSP microprocessor especially for video signal processing substantially.
Dual CLAVATA3 peptides in Arabidopsis shoot stem cell signaling
김현지,Chung-Yi Wu,Hui-Ming Yu,Jen Sheen,이호림 한국식물학회 2017 Journal of Plant Biology Vol.60 No.5
Plant shoot stem cell pool is constantly maintainedby a negative feedback loop through peptide-receptor mediatedsignaling pathway. CLAVATA3 (CLV3) encode a 96 aminoacidprotein which is processed to 12-amino-acid orarabinosylated 13-amino-acid peptides, acting as a ligandsignal to regulate stem cell homeostasis in the shoot apicalmeristem (SAM). Although arabinosylated 13-amino-acidCLV3 peptide (CLV3p) shows more significant bindingaffinity to its receptors and biological activities in the SAM,the physiological function of two mature forms of CLV3premained an unresolved puzzle in the past decade due to thetechnical difficulties of arabinosylation modification in thepeptide synthesis. Here, we analyzed the role of two matureCLV3 peptides with newly synthesized arabinosylated peptide. Beside shoot meristem phenotypes, arabinosylated CLV3pshowed the conventional trait of CLV2-dependent root growthinhibition. Moreover, both 12-amino-acid and arabinosylated13-amino-acid CLV3 peptides have analogous activities inshoot stem cell signaling. Notably, we demonstrated thatnon-arabinosylated 12-amino acid CLV3p can affect shootstem cell signaling at the physiological level unlike previouslysuggested (Ohyama et al. 2009; Shinohara and Matsubayashi2013; Shinohara and Matsubayashi 2015). Therefore, theseresults support the physiological role of the 12-amino-acidCLV3p in shoot stem cell signaling in the deficient conditionof arabinosylated 13-amino-acid CLV3p in Arabidopsisthaliana.
Clement Chun Ho Wu,Samuel Jun Ming Lim,Christopher Jen Lock Khor 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.4
Endoscopic retrograde cholangiopancreatography (ERCP) plays a crucial role in the management of pancreaticobiliary disorders. Although the ERCP technique has been refined over the past five decades, it remains one of the endoscopic procedures with the highest rate of complications. Risk factors for ERCP-related complications are broadly classified into patient-, procedure-, and operator-related risk factors. Although non-modifiable, patient-related risk factors allow for the closer monitoring and instatement of preventive measures. Post-ERCP pancreatitis is the most common complication of ERCP. Risk reduction strategies include intravenous hydration, rectal nonsteroidal anti-inflammatory drugs, and pancreatic stent placement in selected patients. Perforation is associated with significant morbidity and mortality, and prompt recognition and treatment of ERCP-related perforations are key to ensuring good clinical outcomes. Endoscopy plays an expanding role in the treatment of perforations. Specific management strategies depend on the location of the perforation and the patient’s clinical status. The risk of post-ERCP bleeding can be attenuated by preprocedural optimization and adoption of intra-procedural techniques. Endoscopic measures are the mainstay of management for post-ERCP bleeding. Escalation to angioembolization or surgery may be required for refractory bleeding. Post-ERCP cholangitis can be reduced with antibiotic prophylaxis in high risk patients. Bile culture-directed therapy plays an important role in antimicrobial treatment.
Chang, Chih-Chun,Sun, Jen-Tang,Chen, Jing-Yuan,Chen, Yi-Ting,Li, Pei-Yu,Lee, Tai-Chen,Su, Ming-Jang,Wu, Jiann-Ming,Yen, Tzung-Hai,Chu, Fang-Yeh Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Potential disadvantages of blood transfusion during curative gastrectomy for gastric cancer have been reported, and the role of peri-operative transfusions remains to be ascertained. Thus, the aim of our study was to survey its impact in patients with gastric cancer undergoinging gastrectomy. Materials and Methods: Clinical data of patients receiving curative gastrectomy at Far Eastern Memorial Hospital were obtained. Findings for pre-operative anemia states, pre-, peri- and post-operative transfusion of red blood cell (RBC) products as well as post-operative complication events were collected for univariate analysis. Results: A total of 116 patients with gastric cancer received gastrectomy at Far Eastern Memorial Hospital from 2011 to 2014. Both pre-operative and intra- and post-operative transfusion of RBC products were markedly associated with post-operative infectious events (OR: 3.70, 95% CI: 1.43-9.58, P=0.002; OR: 8.20, 95% CI: 3.11-22.62, P<0.001, respectively). In addition, peri- and post-operative RBC transfusion was significantly associated with prolonged hospital stay from admission to discharge (OR: 8.66, 95% CI: 1.73-83.00, P=0.002) and post-operative acute renal failure (OR: 19.69, 95% CI: 2.66-854.56, P<0.001). Also, the overall survival was seemingly decreased by peri-operative RBC transfusion in our gastric cancer cases (P=0.078). Conclusions: Our survey indicated that peri-operative RBC transfusion could increase the risk of infectious events and acute renal failure post curative gastrectomy as well as worsen the overall survival in gastric cancer cases. Hence, unnecessary blood transfusion before, during and after curative gastrectomy should be avoided in patients with gastric cancer.