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Characteristics of South Korean Patients with Hereditary Transthyretin Amyloidosis
Choi, Kyomin,Seok, Jin-Myoung,Kim, Byoung-Joon,Choi, Young-Cheol,Shin, Ha-Young,Sunwoo, Il-Nam,Kim, Dae-Seong,Sung, Jung-Joon,Lee, Ga Yeon,Jeon, Eun-Seok,Kim, Nam-Hee,Min, Ju-Hong,Oh, Jeeyoung 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.4
<P><B>Background and Purpose</B></P><P>This retrospective cross-sectional study included 18 patients from unrelated families harboring mutations of the transthyretin gene (<I>TTR</I>), and analyzed their characteristics and geographical distribution in South Korea.</P><P><B>Methods</B></P><P>The included patients had a diagnosis of systemic amyloidosis, clinical symptoms, such as amyloid neuropathy or cardiomyopathy, and confirmation of a <I>TTR</I> gene mutation using genetic analysis recorded between April 1995 and November 2014.</P><P><B>Results</B></P><P>The mean age at disease onset was 49.6 years, and the mean disease duration from symptom onset to diagnosis was 3.67 years. Fifteen of the 18 patients were classified as mixed phenotype, 2 as the neurological phenotype, and only 1 patient as the cardiac phenotype. The most-common mutation pattern in South Korea was Asp38Ala, which was detected in eight patients. Thirteen patients reported their family hometowns, and five of the eight harboring the Asp38Ala mutation were from the Gyeongsang province in southeast Korea. The other eight patients exhibited a widespread geographical distribution. A particularly noteworthy finding was that the valine at position 30 (Val30Met) mutation, which was previously reported as the most-common <I>TTR</I> mutation worldwide and also the most common in the Japanese population, was not detected in the present South Korean patients.</P><P><B>Conclusions</B></P><P>South Korean patients with hereditary TTR amyloidosis exhibited heterogeneous <I>TTR</I> genotypes and clinical phenotypes. The findings of this study suggest that the distribution of TTR amyloidosis in South Korea is due to de novo mutations and/or related to the other countries in East Asia.</P>
Fire Behavior of Reinforced Concrete Filled Square Steel Tube Columns Under Constant Axial Loads
Jeeyoung Lee,Seulgi Han,Jinwon Shin,Inrak Choi,Sungmo Choi Council on Tall Building and Urban Habitat Korea 2024 International journal of high-rise buildings Vol.13 No.1
A composite member made of concrete-filled steel tubes (CFT columns) has been recognized for its fire resistance due to the thermal mass effect of concrete inside the steel tube, as shown in various studies. In this study, the fire resistance performance of reinforced CFT columns under constant axial load was evaluated using finite element analysis with ABAQUS. For this purpose, the variables including cross-section size, steel tube thickness, and concrete cover thickness were set, and the temperature distribution in the column cross-section exposed to a standard fire was investigated using heat transfer analysis. Ultimately, a P-M interaction curve was obtained by evaluating the overall residual strength of columns, and the fire resistance time was determined by evaluating axial displacement-time responses due to the reduction in load capacity during fire through stress analysis.
국가연구개발사업의 기술적 성과창출 영향요인에 관한 연구
최지영(Jeeyoung Choi),강근복(Keun-bok Kang) 한국기술혁신학회 2016 기술혁신학회지 Vol.19 No.1
국가연구개발사업 성과요인에 대한 실증적 연구는 공식적인 데이터를 이용하여 많은 연구자에 의해 활발하게 수행되고 있다. 하지만, 국가연구개발사업과 산업기술의 특성을 동시에 고려한 실증적 연구는 일부 연구자에 의해서만 이루어지고 있다. 본 연구는 산업기술별 특성이 다르다면 성과창출 영향요인이 다를 것이라는 전제 하에, 부품소재산업경쟁력향상사업의 산업기술별 성과창출 영향요인의 유사점과 차이점을 객관적인 데이터를 이용하여 공분산분석과 다중회귀분석을 통해 실증적으로 비교・분석하였다. 그 결과 산업 기술 분야별로 첫 번째 연구수행주체에 따른 성과의 유의차 여부는 국내특허출원건수, 해외특허출원건수, 논문게재건수의 경우가 다르게 나타났다. 두 번째 과제참여기관수에 따른 성과의 유의차는 상이하게 나타났다. 세 번째 정부연구비에 따른 성과의 유의차 여부는 국내특허출원건수, 해외특허출원건수, SCI 논문게재건수의 경우가 다르게 나타났다. 네 번째 민간투자비율에 따른 성과의 유의차 여부는 표본과 산업에 관계없이 모두 없는 것으로 나타났다. 본 연구를 통해 산업기술별로 주체에 따라 창출하는 성과가 다르며, 성과에 영향을 미치는 요인이 다르다는 것을 확인하였다. 이를 통해 국가연구개발사업 기획 및 성과창출 방안 마련 시 각 산업기술 분야별 특성을 고려한 차별적인 연구개발정책의 필요성을 찾아볼 수 있다. This study aims to analyze the factors that influence the technological performance of national R&D programs, and to compare these factors with those that affect R&D in the machinery and chemical industry. This study also seeks to explore policy implications for the national R&D programs to meet the characteristics of each industrial technology. The results of this study are as follows: First, big enterprises create more Korean patents than small- and medium-sized enterprises (SME) in the machinery R&D. Moreover, government-funded research institutes produce more SCI articles than enterprises in the chemical technology R&D. Second, there is no significant difference in the number of institutions that participate in the machinery technology R&D. Third, the production of Korean patents and Science Citation Index (SCI) articles on all samples in the machinery industry are influenced by government grants. For instance, in the samples, which consist of enterprises, the creation of overseas patents is influenced by the amount of government grants. Fourth, there is no significant difference in the magnitude of private investment, regardless of the sample and industry. In conclusion, different factors influence the technological performances of the national R&D programs in the chemical and machinery technology R&D. This shows that it is necessary to consider the characteristics of industry-specific technology when making science and technology policies for the national R&D programs.