http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ko, Ji-Yun,Park, Chang-Hwan,Koh, Hyun-Chul,Cho, Youl-Hee,Kyhm, Jee-Hong,Kim, Young-Soo,Lee, Inchul,Lee, Yong-Sung,Lee, Sang-Hun Blackwell Publishing Ltd 2007 Journal of Neurochemistry Vol.103 No.4
<P>Abstract</P><P>Human embryonic stem (hES) cells can be guided to differentiate into ventral midbrain-type neural precursor (NP) cells that proliferate <I>in vitro</I> by specific mitogens. We investigated the potential of these NP cells derived from hES cells (hES-NP) for the large-scale generation of human dopamine (DA) neurons for functional analyses and therapeutic applications. To address this, hES-NP cells were expanded <I>in vitro</I> for 1.5 months with six passages, and their proliferation and differentiation properties determined over the NP passages. Interestingly, the total hES-NP cell number was increased by > 2 × 10<SUP>4</SUP>-folds over the <I>in vitro</I> period without alteration of phenotypic gene expression. They also sustained their differentiation capacity toward neuronal cells, exhibiting <I>in vitro</I> pre-synaptic DA neuronal functionality. Furthermore, the hES-NP cells can be cryopreserved without losing their proliferative and developmental potential. Upon transplantation into a Parkinson’s disease rat model, the multi-passaged hES-NP cells survived, integrated into the host striatum, and differentiated toward the neuronal cells expressing DA phenotypes. A significant reduction in the amphetamine-induced rotation score of Parkinson’s disease rats was observed by the cell transplantation. Taken together, these findings indicate that hES-NP cell expansion is exploitable for a large-scale generation of experimental and transplantable DA neurons of human-origin.</P>
A De Novo Centric Fission of Chromosome 11 in a Patient with Recurrent Miscarriages
Shim, Sung Han,Lee, Cheol-Hoon,Lee, Ji-Yeon,Shin, Eun-Sim,Kyhm, Jee Hong,Park, Moon-Il,Chung, Sung-Ro,Cho, Youl-Hee The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.1
<P>We report on a <I>de novo</I> centric fission of chromosome 11 in a healthy female referred for chromosome analysis due to recurrent miscarriages. Both fission products were mitotically stable. This centric fission of chromosome 11 appears to have no clinical significance for this patient other than recurrent miscarriages.</P>