http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models
Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2
Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.
( Si Young Jang ),( Ko Eun Han ),( Yeoung Deuk Jo ),( Hee Jin Jeong ),( Muhammad Irfan Siddique ),( Byoung Cheorl Kang ) 한국육종학회 2015 Plant Breeding and Biotechnology Vol.3 No.2
Capsinoids are the class of secondary metabolites identified in non-pungent peppers exhibiting the same bioactive properties as capsaicinoid. Previously, it has been demonstrated that capsinoid production is controlled by the capsaicin synthase (CS) gene and the putative-aminotransferase (pAMT) gene. In this study, we report that C. chinense ‘SNU11-001’ containing high levels of capsinoid has an early stop codon in pAMT resulted from 403 bp and 8 bp insertions deletion in the third and sixth exons. In order to know whether CS expression is correlated with the level of capsinoid, CS and pAMT expressions were determined using SNU11-001 and four Capsicum accessions with different pungency level. RT-PCR analysis showed higher transcription levels of CS in pungent accessions but no clear differences in pAMT expression. To investigate the effect of the substitution of the pAMT allele of C. chinense ‘Habanero’ with the dysfunctional pAMT allele of SNU11-001, an F2 population was constructed by a cross between aforementioned parental lines. Molecular markers were developed to distinguish CS and pAMT genotypes of SNU11-001 and Habanero and F2 plants were genotyped. All F2 plants having the pAMT genotype of SNU11-001 contained high levels of capsinoid while very low levels of capsaicinoid. There was no significant difference in levels of capsinoid among the F2 plants regardless of CS genotypes. This may be due to strong CS expression of both parental lines. In conclusion, our results show that it is possible to develop a new Habanero cultivar with high capsinoid content by introducing a dysfunctional pAMT allele.
Jang, Si-Young,Lee, Byung-Soo Korean Nuclear Society 2000 Nuclear Engineering and Technology Vol.32 No.4
In Korea, the dose limits are reduced and are set at the ICRP-60 iimits. However, derived limits tabulated as MPC in air and water are still specified in Notice No.98-12. There are some discrepancies between the primary dose limits and MPCs in air and water. Therefore, in order to accept ICRP-60 recommendations fully, derived limits such as ALI, DAC, ECL for radiological protection against ionizing radiation based on ICRP-60 recommendations were calculated using modified methods of those of 10 CFR part 20, dose limits and committed effective dose coefficients of the Basic Safety Standards of the IAEA. The derived limits in this study were also compared with those prescribed in 10 CFR part 20 as well as MPCs of Notice No. 98-12 in order to analyze the impact of implementing derived limits on nuclear facilities. ECLs in air and water for the control of radioactive discharge into the environment in this study are shown to have lower values (i.e. more conservative), for most part, than those in Notice No. 98-12. Especially, for uranium elements, ECLs in water are approximately a magnitude in the order of two lower than those in Notice No.98-12.
A COMPARISON OF USER SATISFACTION WITHIN COMPUTING CONTEXT : PC vs. MAINFRAME
Jang, Si Young 한국경영과학회 1989 한국경영과학회 학술대회논문집 Vol.- No.2
This paper addresses the "PC vs. mainframe" issue by systematically evaluating the usefulness of PCs in an educational context. For this purpose the satisfaction of 47 undergraduate students working with a software package that is available on both PCs and the mainframe was measured and analyzed. The results of the analysis of variance show no interaction effects between computing context and computing experience. Users were more satisfied with PC LINDO than with its mainframe counterpart. Also experienced users showed significantly higher satisfaction than inexperienced users in this study.
Jang Won Young,정우진,장병국,황재석,이헌주,Hwang Moon Joo,Kweon Young Oh,Tak Won Young,Park Soo Young,Lee Su Hyun,Lee Chang Hyeong,Kim Byung Seok,Kim Si Hye,Suh Jeong Ill,Park Jun Gi 대한의학회 2020 Journal of Korean medical science Vol.35 No.29
Background: Liver cirrhosis has become a heavy burden not only for patients, but also for our society. However, little is known about the recent changes in clinical outcomes and characteristics of patients with cirrhosis-related complications in Korea. Therefore, we aimed to evaluate changes in characteristics of patients with liver cirrhosis in Daegu-Gyeongbuk province in Korea over the past 15 years. Methods: We retrospectively reviewed the medical records of 15,716 liver cirrhotic patients from 5 university hospitals in Daegu-Gyeongbuk province from 2000 to 2014. The Korean Standard Classification of Diseases-6 code associated with cirrhosis was investigated through medical records and classified according to the year of first visit. Results: A total of 15,716 patients was diagnosed with cirrhosis. A number of patients newly diagnosed with cirrhosis has decreased each year. In 2000, patients were most likely to be diagnosed with hepatitis B virus (HBV) cirrhosis, followed by alcoholic cirrhosis. There was a significant decrease in HBV (P < 0.001), but alcohol, hepatitis C virus (HCV), and non- alcoholic fatty liver disease (NAFLD) showed a significant increase during the study period (alcohol, P = 0.036; HCV, P = 0.001; NAFLD, P = 0.001). At the time of initial diagnosis, the ratio of Child-Turcotte-Pugh (CTP) class A gradually increased from 23.1% to 32.9% (P < 0.001). The most common cause of liver-related hospitalization in 2000 was hepatocellular carcinoma (HCC) (25.5%); in 2014, gastrointestinal bleeding with esophageal and gastric varices (21.4%) was the most common cause. Cases of hospitalization with liver-related complication represented 76.4% of all cases in 2000 but 70.9% in 2014. Incidence rate of HCC has recently increased. In addition, HCC-free survival was significantly lower in CTP class A than in classes B and C. Finally, there was significant difference in HCC occurrence according to causes (P < 0.001). HBV and HCV cirrhosis had lower HCC-free survival than alcoholic and NAFLD cirrhosis. Conclusion: In recent years, the overall number of cirrhosis patients has decreased. This study confirmed the recent trend in decrease of cirrhosis, especially of cirrhosis due to HBV, and the increase of HCV, alcoholic and NAFLD cirrhosis. Targeted screening for at-risk patients will facilitate early detection of liver diseases allowing effective intervention and may have decreased the development of cirrhosis and its complications.
Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases
Jang, Bohyun,Han, Ji Won,Sung, Pil Soo,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Cho, Young I,Yoon, Seung Kew The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12
<P>Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (<I>P</I> < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: <I>r</I> = −0.25, diastolic: <I>r</I> = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.</P>