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Sargassum swartzii extracts ameliorate memory functions by neurochemical modulation in a rat model
Pirzada Jamal Ahmed Siddiqui,Adnan Khan,Nizam Uddin,Saima Khaliq,Munawwer Rasheed,Shazia Nawaz,Ahsana Dar,Muhammad Hanif 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4
Recently, considerable attention has been paid to drug exploration from natural sources for treating memory loss, a major manifestation of various neurodegenerative diseases. Increasing evidences implicate brain serotonin metabolism in learning and memory, supporting the notion that targeting 5-HT (5-hydroxytryptamine) and its receptors would be beneficial in the treatment of cognitive disorders. In the present study, behavioral and neurochemical effects were examined following administration of Sargassum swartzii extracts in albino Wistar rats. Increase in spatial working memory and recognition memory was exhibited by the seaweed-treated rats as compared to controls. Plasma tryptophan, brain 5-HT, and 5-hydroxyindoleacetic acid levels were measured using HPLC–ECD, and a significant increase in brain 5-HT metabolism was observed in the seaweed-treated rats. The increase in memory functions following repeated administration of S. swartzii extracts is suggested to be due to the increased serotonergic neurotransmission in the brain of seaweed-treated rats.
Elsamany, Shereef Ahmed,Alzahrani, Abdullah Saeed,Mohamed, Mervat Mahrous,Elmorsy, Soha Ali,Zekri, Jamal Eddin,Al-Shehri, Ahmed Saleh,Haggag, Rasha Mostafa,Alnagar, Ahmed Abdel-Reheem,El Taani, Hani A Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: The prognosis of young colorectal cancer (CRC) patients has been addressed by several studies but with contradictory results. The aim of the present study was to evaluate the clinico-pathological features of young Saudi patients with CRC in addition to displaying their survival outcome. Materials and Methods: In this retrospective study, young CRC patients (${\leq}40$ years) diagnosed between 2007 and 2011 from 4 centres in western Saudi Arabia, were included. Clinico-pathological features, tumor markers, dates of disease relapse and death were collected. Survival parameters were compared with those of older Saudi patients, reported in previous studies. Results: One hundred and sixteen young patients with CRC were identified (32.2% rectal, 67.8% colon). Some 44% were metastatic while 32.7% had stage III at diagnosis. Patients with grade 3 tumors made up 29.4% of the total while 49.5% had positive lymphovascular invasion (LVI), 56% had a lymph node (LN) ratio ${\geq}0.2$ and 40.2% were K-ras mutant. Median disease-free survival (DFS) and overall survival (OS) in non-metastatic cases were 22.8 and 49.6 months respectively with better median DFS in K-ras wild compared to mutant patients (28.5 vs 20.9 months, p=0.005). In metastatic cases, median OS was 19.5 months. These survival outcomes are inferior compared to those of older Saudi patients reported in prior studies. Conclusions: Young CRC patients present more commonly with advanced stage and a high incidence of adverse prognostic factors such as LVI and high LN ratio. Young CRC patients seem to have worse survival compared to older Saudi patients.
Screening of some Bangladeshi medicinal plants for in vitro antibacterial activity
Shaikh Jamal Uddin,Razina Rouf,Jamil Ahmed Shilpi,Mohammad Alamgir,Lutfun Nahar,Satyajit Dey Sarker 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3
A total of 33 extracts representing 26 plant species belonging to 24 families were collected from different regions of Bangladesh, and screened for their in vitro antibacterial activity against several pathogenic Gram-positive and Gram-negative bacterial strains using the conventional disc diffusion method. The most potent activity was exhibited by the extracts of Aegiceras corniculatum, Alocasia fornicata, Ceriops decandra, Cuscuta reflexa, Lasia spinosa, Lantana camara, Pandanus foetidus and Xylocarpus granatum. The extracts of Abtilon indicum, Derris trifoliata, Dendrophthoe falcat, Ruellia tuberosa and X. moluccensis did not show any antibacterial properties at test concentrations. A total of 33 extracts representing 26 plant species belonging to 24 families were collected from different regions of Bangladesh, and screened for their in vitro antibacterial activity against several pathogenic Gram-positive and Gram-negative bacterial strains using the conventional disc diffusion method. The most potent activity was exhibited by the extracts of Aegiceras corniculatum, Alocasia fornicata, Ceriops decandra, Cuscuta reflexa, Lasia spinosa, Lantana camara, Pandanus foetidus and Xylocarpus granatum. The extracts of Abtilon indicum, Derris trifoliata, Dendrophthoe falcat, Ruellia tuberosa and X. moluccensis did not show any antibacterial properties at test concentrations.
On Extended Hurwitz-Lerch Zeta Function
Mohannad Jamal Said Shahwan,Maged Gumman Bin-Saad,Mohammed Ahmed Pathan 경북대학교 자연과학대학 수학과 2023 Kyungpook mathematical journal Vol.63 No.3
This paper investigates an extended form Hurwitz-Lerch zeta function, as well as related integral images, ordinary and fractional derivatives, and series expan sions, using the term extended beta function. In addition, we establish a connection between the extended Hurwitz-Lerch zeta function and the Laguerre polynomials. Fur thermore, we present a probability distribution application of the extended Hurwitz-Lerch zeta functionζδ,µν,λ. Several (known and new) results are shown to follow as special cases of our findings.
Screening of some Bangladeshi medicinal plants for in vitro antibacterial activity
Uddin, Shaikh Jamal,Rouf, Razina,Shilpi, Jamil Ahmed,Alamgir, Mohammad,Nahar, Lutfun,Sarker, Satyajit Dey Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.3
A total of 33 extracts representing 26 plant species belonging to 24 families were collected from different regions of Bangladesh, and screened for their in vitro antibacterial activity against several pathogenic Gram-positive and Gram-negative bacterial strains using the conventional disc diffusion method. The most potent activity was exhibited by the extracts of Aegiceras corniculatum, Alocasia fornicata, Ceriops decandra, Cuscuta reflexa, Lasia spinosa, Lantana camara, Pandanus foetidus and Xylocarpus granatum. The extracts of Abtilon indicum, Derris trifoliata, Dendrophthoe falcat, Ruellia tuberosa and X. moluccensis did not show any antibacterial properties at test concentrations.
Fekri Abdulraqeb Ahmed Ali,Javed Alam,Arun Kumar Shukla,Mansour Alhoshan,Jamal M. Khaled,Waheed A. Al-Masry,Naiyaf S. Alharbi,Manawwer Alam 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Biofouling leads to degradation of membrane performance characteristics, including permeability,selectivity, and long-term stability. In this study, silver-doped graphene oxide (GO) was employed as ananoadditive to enhance the biofouling resistance of thin-film nanocomposite (TFN) membranes viainterfacial polymerization. Ag functionalization on GO sheets was carried out by a reduction reaction. Electron microscopy, Raman spectroscopy, and X-ray diffraction analyses were conducted to evaluate Agattachment on GO. According to zeta potential and contact angle measurements as well as atomic forcemicroscopy results, GO-Ag-incorporated TFN membranes showed a high negative charge, hydrophilicity,and a smooth surface. Bovine serum albumin protein and Escherichia coli (E. coli) were used as modelfouling agents to demonstrate the antifouling characteristics of the membranes. The TFN membranecontaining 80 ppm of GO-Ag had a high waterflux recovery ratio (89%) and low irreversible resistance(10%) after hydraulic washing. The biofouling resistance of the membranes was further studied by acolony-counting method, while bacterial adhesion was analyzed by spinning disk confocal microscopeimaging. The TFN membrane prepared with 80 ppm GO-Ag reduced 86% of viable E. coli cells in bacterialsuspensions, with only slight bacterial adherence on the membrane surface.
Rainwater for Water Scarcity Management: An Experience of Woldia University (Ethiopia)
Venkatesh ANDAVAR,Bayad Jamal ALI,Sazan Ahmed ALI 한국유통과학회 2020 Asian Journal of Business Environment (AJBE) Vol.10 No.4
Purpose: Town of Woldia, a semi-arid region in the Northern Wollo region of Ethiopia, faces water supply shortage in general, though the town possesses a running stream of clean water throughout the year. This study is aimed at analyzing the possibility of using rainwater for water scarcity and non-potable water needs of the Woldia University. A careful study and analysis have been made to assess the feasibility of using rainwater in place of the tap water supply. Research design and methodology: This study was done inside the main campus of Woldia University located in Woldia town. The runoff water from the roof of buildings was studied, by the time of rainfall in the town. Also, the budget needed for implementing a rainwater harvesting system was calculated. Results: The findings of the study clearly indicates that the requirements of the water to use for flushing, cleaning, and washing toilets in the administrative buildings and classrooms can be satisfied by using rainwater as an alternative to tap water. Conclusion: Based on the results the study finds it is benefitable for the Woldia University to install the rainwater harvesting system at the earliest to solve the water problems prevailing in the current situation.
Hasan, Md Shihab,Ahmed, Md Iqbal,Mondal, Sukla,Masud, Mohammad Methedi,Sadhu, Samir Kumar,Ishibashi, Masami,Uddin, Shaikh Jamal Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.4
Plants have been used in traditional medicinal system for centuries. Bangladeshi medicinal plants have received considerable attention from the researchers for evaluation of their bioactivity. As a part of our ongoing research of screening the Bangladeshi medicinal plants, the ethanolic extract of Dendrophthoe falcata have been chosen for the present study. The ethanolic extract of the leaves of the plant have been assessed for their antioxidant, antinociceptive, and general toxicity. The extract showed potent antioxidant activity ($IC_{50}5.1{\mu}g/ml$) using DPPH radical scavenging assay, which is comparable to the standard ascorbic acid ($IC_{50}4.6{\mu}g/ml$). The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (71.2%, P < 0.001 and 28.0%, P < 0.05 for 500 and 250 mg/kg body weight, respectively). A general toxicity was assessed by a simple and low cost assay using brine shrimp lethality as an indicator. The extract showed low level of toxicity ($LC_{50}100{\mu}g/ml$). Using different chromatographic techniques, quercitrin (quercetin 3-O-${\alpha}$-rhamnoside) was separated as the major component from the extract. The structure was elucidated by detailed 1D and 2D NMR and mass spectral analysis.