http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jaekwang Kim (검색결과 186 건)
- 무료
- 기관 내 무료
- 유료
-
Kim, Kiyoung,Kim, Song-Hee,Kim, Jaekwang,Kim, Heuijong,Yim, Jeongbin American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.9
<▼1><P><B>Background:</B> Glutathione <I>S</I>-transferase Omega has been shown to be associated with Parkinson disease.</P><P><B>Results:</B><I>Drosophila</I> GSTO1 regulates mitochondrial ATP synthase activity in <I>parkin</I> mutants.</P><P><B>Conclusion:</B><I>Drosophila</I> GSTO1 plays a protective role in a <I>Drosophila</I> model of Parkinson disease.</P><P><B>Significance:</B> These findings may lead to a better understanding of the molecular mechanism of neuroprotection due to GSTO in Parkinson disease.</P></▼1><▼2><P>A loss-of-function mutation in the gene <I>parkin</I> causes a common neurodegenerative disease that may be caused by mitochondrial dysfunction. Glutathione <I>S</I>-transferase Omega (GSTO) is involved in cell defense mechanisms, but little is known about the role of GSTO in the progression of Parkinson disease. Here, we report that restoration of <I>Drosophila</I> GSTO1 (DmGSTO1), which is down-regulated in <I>parkin</I> mutants, alleviates some of the <I>parkin</I> pathogenic phenotypes and that the loss of <I>DmGSTO1</I> function enhances <I>parkin</I> mutant phenotypes. We further identified the ATP synthase β subunit as a novel <I>in vivo</I> target of DmGSTO1. We found that glutathionylation of the ATP synthase β subunit is rescued by DmGSTO1 and that the expression of DmGSTO1 partially restores the activity and assembly of the mitochondrial F<SUB>1</SUB>F<SUB>0</SUB>-ATP synthase in <I>parkin</I> mutants. Our results suggest a novel mechanism for the protective role of DmGSTO1 in <I>parkin</I> mutants, through the regulation of ATP synthase activity, and provide insight into potential therapies for Parkinson disease neurodegeneration.</P></▼2>
-
-
Kim, Hyun-seung,Kim, Jaekwang,Kim, Hyosung,Kim, Youngjin,Ryu, Ji Heon,Oh, Seung M.,Yoon, Songhun Elsevier 2018 Journal of Electroanalytical Chemistry Vol.808 No.-
<P><B>Abstract</B></P> <P>A hydrothermally synthesized tin (IV) sulfide electrode was examined for use as a negative electrode in sodium-ion batteries. Using ex-situ XRD and electrochemical analysis, the sodiation mechanism of tin (IV) sulfide was clarified, which revealed that the typical conversion reaction-coupled alloying reaction happened during sodiation with a high reversible capacity (~640mAhg<SUP>−1</SUP>). Also, the improved cycleability was observed in the tin (IV) sulfide electrode when compared with tin metal electrode. From comparison of quasi-open-circuit voltages at the 20th de-sodiated electrode, it was revealed that sodium trapping was considerably suppressed by sulfide formation with tin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hydrothermally-synthesized tin (IV) sulfide (SnS<SUB>2</SUB>) is applied as negative electrode for sodium-ion batteries. </LI> <LI> Hydrothermally-synthesized SnS<SUB>2</SUB> shows stable cycleability. </LI> <LI> The dead particle generation is very suppressed at SnS<SUB>2</SUB> negative electrode. </LI> </UL> </P>
-
A Novel Frame rate Conversion Method by Using Improved True Motion Estimation
Jaekwang Kim,Sanghoon Song,Dongil Han 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
In this paper, a method of estimating true motion vectors to reduce image quality deterioration such as block artifact is proposed. Three consecutive original input images are used to calculate the motion vectors. Bi-directional motion estimation, forward directional motion estimation, backward directional motion estimation is performed. The minimum SSD(Sum of Square Difference) obtained by bi-directional motion estimation compares each of the SSD values obtained by motion estimation of the forward and backward direction. And this will determine the optimal MV of forward, backward direction. Then, the estimated true motion vector is applied to frame interpolation.
-
Jaekwang Kim,Hyejin Yoon,Jacob Basak,Jungsu Kim 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.11
Alzheimer’s disease (AD) is clinically characterized with progressive memory loss and cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to neurodegeneration and memory dysfunction. Mounting evidence suggests that aggregation of amyloid-β (Aβ) and hyperphosphorylated tau leads to synaptic deficits and neurodegeneration, thereby to memory loss. Among the established genetic risk factors for AD, the ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor. We and others previously demonstrated that apoE regulates Aβ aggregation and clearance in an isoform- dependent manner. While the effect of apoE on Aβ may explain how apoE isoforms differentially affect AD pathogenesis, there are also other underexplored pathogenic mechanisms. They include differential effects of apoE on cerebral energy metabolism, neuroinflammation, neurovascular function, neurogenesis, and synaptic plasticity. ApoE is a major carrier of cholesterols that are required for neuronal activity and injury repair in the brain. Although there are a few conflicting findings and the underlying mechanism is still unclear, several lines of studies demonstrated that apoE4 leads to synaptic deficits and impairment in long-term potentiation, memory and cognition. In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.
-
Novel estimation method of operating life in lithium-ion pouch cells
Kim, Hyosung,Kim, Jaekwang,Kim, Nayeong,Lee, Ilbok,Hwang, Keebum,Bae, Joongho,Yoon, Songhun THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.67 No.-
<P><B>Abstract</B></P> <P>Herein, a novel operating life (OL) test method was evaluated with 200mAh pouch-type lithium-ion batteries. By combining the calendar life (CL) test with intermediate pulse power cycling, more realistic life prediction was possible, which encompassed real operation of batteries accompanying with thermal acceleration. Larger capacity decrease and resistance increase of pouch cell were observed in the OL test, which was well explained using the SEI film growth model. After dissemble of pouch cell, capacity loss and resistance increase mostly occurred within anode, reflecting that SEI film growth on anode surface was highly attributable to cell degradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Suggestion of novel operating life prediction. </LI> <LI> Intermediate pulse power cycling to simulate vehicle operation. </LI> <LI> Combination of pulse power cycling and thermal degradation by calendar life prediction. </LI> <LI> Surface film growth model to explain capacity and resistance change. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
-
Kim, Hyun-seung,Kim, Jaekwang,Jang, Jihyun,Kim, Nayeong,Ryu, Ji Heon,Yoon, Songhun,Oh, Seung M. Elsevier 2017 Solid state ionics Vol.311 No.-
<P><B>Abstract</B></P> <P>In this study, polarization behavior during initial lithiation step was comparatively investigated using a tungsten oxide (WO<SUB>3</SUB>) and its reduced one (WO<SUB>3− <I>x</I> </SUB>). Ex-situ X-ray diffraction revealed that the overall lithiation process in WO<SUB>3</SUB> was mostly similar to that of WO<SUB>3− <I>x</I> </SUB>, which was associated with the typical conversion reaction of transition-metal oxide. In the WO<SUB>3− <I>x</I> </SUB> anode, however, insertional lithiation was initiated above 2V vs. Li/Li<SUP>+</SUP> and a following conversion reaction was observed, which was different charging behavior from WO<SUB>3</SUB> electrode. The severe polarization related with the conversion reaction was alleviated owing to the high electrical conductivity in the mixed-valance state of WO<SUB>3− <I>x</I> </SUB>. Furthermore, the different initial polarization in WO<SUB>3− <I>x</I> </SUB> anode resulted in the improvement of cycle performance and efficiency.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
-
Kim, Jaekwang,Yoon, Hyejin,Basak, Jacob,Kim, Jungsu Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.11
Alzheimer's disease (AD) is clinically characterized with progressive memory loss and cognitive decline. Synaptic dysfunction is an early pathological feature that occurs prior to neurodegeneration and memory dysfunction. Mounting evidence suggests that aggregation of amyloid-${\alpha}$ ($A{\alpha}$) and hyperphosphorylated tau leads to synaptic deficits and neurodegeneration, thereby to memory loss. Among the established genetic risk factors for AD, the ${\varepsilon}4$ allele of apolipoprotein E (APOE) is the strongest genetic risk factor. We and others previously demonstrated that apoE regulates $A{\alpha}$ aggregation and clearance in an isoform-dependent manner. While the effect of apoE on $A{\alpha}$ may explain how apoE isoforms differentially affect AD pathogenesis, there are also other underexplored pathogenic mechanisms. They include differential effects of apoE on cerebral energy metabolism, neuroinflammation, neurovascular function, neurogenesis, and synaptic plasticity. ApoE is a major carrier of cholesterols that are required for neuronal activity and injury repair in the brain. Although there are a few conflicting findings and the underlying mechanism is still unclear, several lines of studies demonstrated that apoE4 leads to synaptic deficits and impairment in long-term potentiation, memory and cognition. In this review, we summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2.
-
-
Kim, Hyun-seung,Kim, Jongjung,Lee, Jae Gil,Ryu, Ji Heon,Kim, Jaekwang,Oh, Seung M.,Yoon, Songhun Elsevier 2018 Solid state ionics Vol.314 No.-
<P><B>Abstract</B></P> <P>A cheap Si powder byproduct from solar cell production was applied as a negative electrode for lithium-ion batteries. To improve the cycle and rate performances, the as-obtained Si powder was composited with tungsten oxide and coated with carbon, in sequence. After preparing the composite material, its electrochemical performance is evaluated, which exhibits a high reversible capacity of 975mAhg<SUP>−1</SUP> with improved cycleability. Especially, the rate capability is significantly improved to 390mAhg<SUP>−1</SUP> under 1000mAg<SUP>−1</SUP> applied current. This advanced electrochemical performance is attributed to the matrix effect of the formed Li<SUB>2</SUB>O and W metal with carbon coating, as identified using ex-situ X-ray diffraction experiments, and associated with the low polarization resistance observed in the galvanostatic charge intermittent technique.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Preparation of composite between Si powder with tungsten oxide and carbon </LI> <LI> Improved capacity and cycleability due to buffer phase of W and Li<SUB>2</SUB>O </LI> <LI> High rate capability of prepared composite from low polarization of electrode </LI> </UL> </P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
