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Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana
Kim, Mi Seon,Lee, Yunmi,Sung, Gi-Ho,Kim, Ji Hye,Park, Jae Gwang,Kim, Han Gyung,Baek, Kwang Soo,Cho, Jae Han,Han, Jaegu,Lee, Kang-Hyo,Hong, Sungyoul,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.
Kim, Kyungsang,Lee, Taewon,Seong, Younghun,Lee, Jongha,Jang, Kwang Eun,Choi, Jaegu,Choi, Young Wook,Kim, Hak Hee,Shin, Hee Jung,Cha, Joo Hee,Cho, Seungryong,Ye, Jong Chul Published for the American Association of Physicis 2015 Medical physics Vol.42 No.9
<P>In digital breast tomosynthesis (DBT), scatter correction is highly desirable, as it improves image quality at low doses. Because the DBT detector panel is typically stationary during the source rotation, antiscatter grids are not generally compatible with DBT; thus, a software-based scatter correction is required. This work proposes a fully iterative scatter correction method that uses a novel fast Monte Carlo simulation (MCS) with a tissue-composition ratio estimation technique for DBT imaging.</P>
Kim, Jaegu,Kim, Jae-Hyun,Cho, Sung-Hak,Whang, Kyung-Hyun Springer-Verlag 2016 APPLIED PHYSICS A MATERIALS SCIENCE AND PROCESSING Vol.122 No.4
<P>Selective laser lift-off of GaN from a sapphire substrate was demonstrated using 266-nm diode-pumped solid-state laser irradiation. To fabricate a single GaN light-emitting diode (LED) with a size of 100 mu m 9 100 mu m, we used a simple direct scanning technique with a defocused beam and investigated the liftoff parameter in terms of the intensity. Two processing windows corresponding to lower- and higher-intensity regimes were observed experimentally. In the lower-intensity regime, the larger beam size worked better than with the higher regime. Although fluence is generally explained as a processing condition, the total input fluence for a single LED was not crucial to lift-off in case of the scanning technique using a defocused laser beam. However, an intensity of similar to 37 kW/cm(2) was required to initiate the thermal decomposition reaction in GaN at any sample position.</P>
Micro-Cutting with Diamond Tool Micro-Patterned by Femtosecond Laser
Kim, Jaegu,Je, Tae-Jin,Cho, Sung-Hak,Jeon, Eun-Chae,Whang, Kyung-Hyun 한국정밀공학회 2014 International Journal of Precision Engineering and Vol.15 No.6
The demand for micro-scale surface machining has been steadily increasing, and various methods have been introduced. Among these, microcutting with a diamond tool removes material by making multiple cutting passes. However, many passes are needed to generate micropatterns over a large area. To overcome the drawbacks of this time-consuming process, we propose a novel method, which uses a micropatterned diamond tool. A 220-fs-pulsed Ti: Sapphire laser is used to create micropatterns on the edge line of a rectangular diamond tool. A six-axis motion stage is used to align the edge line and flank surface of the diamond tool with respect to the focal point of the laser beam. Using a simple laser direct-writing method and a $100{\times}$ objective lens (NA: 0.8), lines ${\leq}2{\mu}m$ in width, $20{\mu}m$ in length, and $10{\mu}m$ in separation were fabricated along the 1-mm edge line of a bulk diamond tool. The micropatterned diamond cutting tool was then used to successfully produce micropatterns on the surface of nickel (Ni)-electroformed on SKD-61. This novel process provides an efficient means of multiple micropattern generation for molding applications, such as those required for optics and biotechnology, using only a single pass of a diamond cutting tool.
김재구(JaeGu Kim),구동식(DongSik Gu),최병근(ByeongKeun Choi) 한국소음진동공학회 2011 한국소음진동공학회 학술대회논문집 Vol.2011 No.4
The acoustic emission (AE) technique is a well-known non-destructive test technique, both in research and for industrial applications. It is mainly used to monitor the onset of cracking processes in materials and components. Predicting and preventing the crack phenomenon has attracted the attention of many researchers and has continued to provide a large incentive for the use of condition monitoring techniques to detect the earliest stages of cracks. In this research, goal is in grasping features of AE signal caused by crack growth. The envelope analysis with discrete wavelet transform (DWT) is used to find the characteristic of AE signal. To estimate feature of divided into three by crack length, the time waveform and the power spectrum were generated by the raw signals and the transferred signal processed by envelope analysis with DWT.