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Jae Myun Ryu,Jung-He Cho,Hee-Youl Chai,Tae Myung Kim,Jung-Hui Park,Yun-Bae Kim,Seok-Yeon Hwang 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
The cholesterol-lowering and antiatherosclerotic effects of Mori radicis cortex-water extracts (MRC-WE) in hypercholesterolemic rabbits were investigated. Male New Zealand white rabbits were fed a high-cholesterol diet containing 1% cholesterol and 2% corn oil for 2 weeks, and then MRC-WE (1% or 3%) or lovastatin (0.002%) were added to the diet for additional 8 weeks. The levels of blood cholesterol, low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were greatly increased by 2-week feeding the high-cholesterol diet, compared with those of animals fed normal diet. Blood concentrations of cholesterol, LDL and triglycerides further increased during additional 8-week feeding the high-cholesterol diet alone, in contrast to significant decrease in HDL level. In comparison, the levels of cholesterol and LDL were reduced by lovastatin and MRC-WE (1%), in addition to less-severe decrease in HDL contents. In addition, lovastatin and MRC-EE (1%) lowered lipid deposition in hepatocytes, showing restricted distribution of foamy hepatocytes. The thick atheromatous plaques (mean score 2.75) on the aortic wall of rabbits fed the high-cholesterol diet were markedly attenuated by lovastatin or MRC-WE (1%), leading to the decrease in athrosclerosis indices to 2.0 and 2.25, respectively. It is suggested that a low level (1%) of MRC-WE exerts antiatherosclerotic effect by reducing blood cholesterol and LDL.
Jae Myun Ryu,Tae Myoung Kim,Hyun Jung Kwon,Hae-Jeung Lee,Haymie Choi,Heon Sang Jeong,Jin Tae Hong,Dae Joong Kim 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
An investigation was conducted to examine the chemopreventive effects of Korean ginseng (Panax ginseng C.A. Mayer) extract (KGE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH). Five-week-old male F344 rats were fed with a diet containing 0.5% or 1% of KGE for 8 weeks. During the initial 2 weeks, the rats were subcutaneously injected with DMH (30 ㎎/㎏) or saline 4 times to induce colonic ACF. The ACF formed on the colonic mucosa were examined after staining with methylene blue. Four-times treatment with DMH induced mean 265.8 ± 48.3 ACF/colon composed of total 608.8 ± 110.9 aberrant crypts (AC)/colon. The numbers of ACF and AC induced by DMH were significantly decreased to 190.3±49.9 and 467.6±127.3, respectively, by treatment with 0.5% KGE, and further reduced to 168.1 and 389.8±125.1 by 1% KGE. Especially, the number of large ACF (≥4 AC/ACF), that had been suggested to possess a greater tumorigenic potential than small ACF (≤3 AC/ACF), was greatly suppressed from 39.9 ± 10.6 ACF/colon in control to 26.2± 11.1 ACF/colon in 1% KGE-treated group. These results suggest that KGE exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the development of ACF and AC in the rats.
Repeated-Dose Toxicity of Misaengtang in Rats
Jae Myun Ryu,Yong Hoon Chang,Tae Hee Lee,Im Kwon Seo,Seung Ho Lee,Youn-Bae Kim,Seock-Yeon Hwang 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
Repeated-dose toxicity of Misaengtang (MST) was evaluated according to Toxicity Test Guidelines of Korea Food and Drug Administration using Sprague-Dawley rats. For single-dose toxicity study, MST was dissolved in drinking water, orally administered and examined for 14 days. As results, MST up to a dose of 5,000 ㎎/㎏, the limited dose, neither induced death, clinical signs and necropsy findings, nor affected body weight gain and organ weights, in which 10% lethal dose could not be estimated. Based on the results of single-dose toxicity test, MST was administered at doses of 500, 1,000 or 2,000 ㎎/㎏ for 28 days for the evaluation of repeated-dose toxicity. All doses including the limited dose (2,000 ㎎/㎏) of MST did not cause any abnormalities of rats, including mortality, clinical signs, body weight gain, feed/water consumption, necropsy findings, organ weights, hematology, blood biochemistry. Rather, high doses (1,000-2,000 ㎎/㎏) of MST reduced the serum levels of alanine transaminase (ALT), aspartate transaminase (AST), creatinine phosphokinase (CPK), lactate dehydrogenase (LDH) and triglycerides, in addition to an increase in glucose, indicative of protective effects on hepatic and muscular injuries. Thus, both maximum tolerable dose (MTD) and no observed adverse effect level (NOAEL) were not determined. The results indicate that long-term intake of high-dose MST might not induce general adverse effects.
Jae Myun Ryu,Im Kwon Seo,Tae Myoung Kim,Yun-Bae Kim,Sung Kwon Moon,Kyung-Hwan Jung,Keerang Park,Seung Bok Hong,Seock-Yeon Hwang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.2
The chemopreventive effects of Magnolia ovobata water extract (MWE) and 70% ethanol extract (MEE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) were investigated. Six-week-old male F344 rats were divided to 7 experimental groups; 1) DMH alone, 2) DMH+0.3% MWE, 3) DMH+1% MWE, 4) DMH+3% MWE, 5) DMH+1% MEE, 6) 3% MWE alone and 7) normal control. Animals were subcutaneously injected with DMH (30 mg/kg) 4 times to induce colonic ACF during the initial 2 weeks, and fed with a basal containing various concentrations of test materials (MWE or MEE) for 8 weeks including the DMH-treatment period. The formation of ACF on colonic mucosa was observed after staining with methylene blue. There are no specific effects of MWE and MEE on body weight, feed and water consumptions, organ weights, histopathological observations, and hematological and blood chemistry analyses. Challenge with DMH alone induced mean number of 270.1 ACF/colon which was somewhat inhibited by MWE treatment, showing average numbers of 234.3-242.1 ACF/colon. In comparison, the ACF number was significantly suppressed to 216.5 by administration of 1% MEE. Therefore, these results suggest that Magnolia ovobata extracts, especially MEE, exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the early development of ACF.
Effects of sorghum ethyl-acetate extract on PC3M prostate cancer cell tumorigenicity
Ryu, Jae-Myun,Jang, Gwi Yeong,Woo, Koan Sik,Kim, Tae Myoung,Jeong, Heon Sang,Kim, Dae Joong Elsevier 2017 Journal of Functional Foods Vol.37 No.-
<P><B>Abstract</B></P> <P>Prostate cancer is the second most common cancer in males. The side effects of convention antineoplastic drugs and sustained risks of recurrence and metastasis necessitate the search for safer chemopreventive and chemotherapeutic drugs. The cereal grain sorghum contains various polyphenols with potent anti-cancer and antioxidant activities. To evaluate the anti-tumor efficacy of Donganme sorghum ethyl-acetate extract (DSEE), we performed content analysis and evaluated its effects on PC3M prostate cancer cell proliferation, cell cycle progression, and migration in vitro, and on PC3M orthotopic tumor growth in vivo. DSEE decreased viable cell number in a dose-dependent manner, increased apoptosis rate by activating the intrinsic apoptosis pathway, induced cell cycle arrest at G0 by reducing cyclin expression, suppressed cell migration and expression of matrix metalloproteinase-2 and -9. Moreover, DSEE inhibited orthotopic tumor growth and metastasis in mice. Therefore, DSEE may have potential preventive and therapeutic efficacy against prostate cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> DSEE induced PC3M prostate cancer cell apoptosis and cell cycle arrest. </LI> <LI> DSEE reduced PC3M cell mobility and expression levels of MMP2 and MMP9. </LI> <LI> DSEE inhibited orthotopic prostate tumor growth and metastasis in mice. </LI> </UL> </P>