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Retrospective analysis of transbronchial cryobiopsy: the first report in Korea
( Woori Jo ),( Chuiyong Pak ),( Jin Hyoung Kim ),( Soohyun Bae ),( Byung Ju Kang ),( Seung Won Ra ),( Kwang Won Seo ),( Jong Joon Ahn ),( Soyeoun Lim ),( Hee Jeong Cha ),( Taehoon Lee ),( Yangjin Jega 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Interstitial lung diseases(ILD) are heterogeneous group of lung diseases that require a multidisciplinary approach through discussion with clinicians, radiologists, and pathologists. Surgical lung biopsy is the gold standard for pathologic diagnosis of ILD. Recently, the usefulness of transbronchial cryobiopsy (TBC) has increased in the assessment of ILD. As far as we know, there is no study in Korea on the role of TBC in ILD diagnosis, yet. This study first evaluated the significance of TBC in suspected cases of ILD in Korea. Methods: The medical records of 17 patients suspected of ILD who were performed TBC at Ulsan University Hospital from August 2016 to June 2019 were retrospectively evaluated. Results: Seventeen patients with a mean age of 67 years were included in this analysis and there were 47%(eight patients) of women. The 1.9 mm sized probe was used for three patients and 2.4 mm sized probe was used for 14 patients. The median number of specimens per procedure was four (range; 1-9). The mean diameter of the specimens was 0.5 cm(range; 0.2-1.2cm). The diagnostic yield of TBC was 47.1%(eight patients). The frequent histopathologic results included usual interstitial pneumonia(two patients), organizing pneumonia(two patients) and adenocarcinoma(two patients). In the multidisciplinary diagnosis, they were diagnosed with idiopathic pulmonary fibrosis(two patients), cryptogenic organizing pneumonia(two patients) and adenocarcinoma(two patients). Four of the nine patients with non-diagnostic histopathologic patterns were able to be diagnosed after a multidisciplinary review. As a result, the number of patients who could be diagnosed by TBC increased to 12 patients(70.6%). The complication occurred in eight patients including mild bleeding (three patients) and pneumothorax(four patients). Conclusions: The diagnostic yield of TBC in this study was 47.1% and increased to 70.6% after a multidisciplinary diagnosis. The value of TBC as the alternative methods of surgical lung biopsy should be evaluated through further study.
Metformin inhibits early stage diethylnitrosamine-induced hepatocarcinogenesis in rats
JO, WOORI,YU, EUN-SIL,CHANG, MINSUN,PARK, HYUN-KYU,CHOI, HYUN-JI,RYU, JAE-EUN,JANG, SUNGWOONG,LEE, HYO-JU,JANG, JA-JUNE,SON, WOO-CHAN SPANDIDOS PUBLICATIONS 2016 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Antitumor effects of metformin have recently emerged despite its original use for type II diabetes. In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)-induced rat model of HCC. Tumor foci were characterized by gross examination and by histopathological characteristics, including proliferation, hepatic progenitor cell content and the expression of hepatocarcinoma-specific molecular markers. Potential target molecules of metformin were investigated to determine the molecular mechanism underlying the inhibitory effects of metformin on chemically induced liver tumorigenesis. The antitumor effects of metformin were increased by the reduction of surface nodules and decreased the incidence of altered hepatocellular foci, hepatocellular adenoma and carcinoma. Also, decreased expression levels of glutathione S-transferase placental form, proliferating cell nuclear antigen and cytokeratin 8 described the inhibitory effects of metformin on HCC. In the present study, Wistar rats receiving treatment with DEN were administered metformin for 16 weeks. In addition, metformin suppressed liver tumorigenesis via an AMPK-dependent pathway. These results suggested that metformin has promising effects on the early stage of HCC in rats. Therefore, metformin may be used for the prevention of HCC recurrence following primary chemotherapy for HCC and/or for high-risk patients, including chronic hepatitis and cirrhosis.</P>
Jo Woori,Seo Kwang Won,Jung Hwa Sik,Park Chui Yong,Kang Byung Ju,Kang Hyeon Hui,Ra Seung Won,Jegal Yangjin,Ahn Jong Joon,Park Soon Eun,Jung Moon Sik,Park Ju Ik,Park Eun Ji,Sim Chang Sun,Kim Tae-Bum,Le 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.2
Purpose: Work-related asthma (WRA) occupies about 10%–30% of all asthma cases. Among 2 subtypes of WRA (occupational asthma [OA] and work-exacerbated asthma [WEA]), the rate of WEA has been reported to increase recently. WRA is described as having worse characteristics than non-WRA (NWRA), while WEA is known to show similar severity to OA in terms of symptoms and exacerbations. However, these data were mainly based on indirect surveys. Ulsan is a highly industrialized city in Korea; therefore, it is estimated to have a high incidence of WRA. This study aimed to identify the characteristics of WRA in the city. Methods: This was a prospective asthma cohort study of individuals diagnosed with asthma and treated at Ulsan University Hospital between Jan 2015 and Dec 2016. Baseline characteristics and work-related inquiry (9 questionnaires) were investigated at enrollment. Various severity indices and job change were then investigated for the longitudinal analysis at 12 months after enrollment. Results: In total, 217 asthma patients completed the study. WRA accounted for 17% (36/217), with an equal number of WEA and OA (18 patients each). Before the work-related survey, only 33% (n = 12) of WRA patients (22% [4/18] of WEA and 44% [8/18] of OA) were diagnosed with WRA by the attending physicians. Compared to the NWRA group and the OA subgroup, the WEA subgroup had more outpatient visits, more oral corticosteroids prescriptions, and trends of low asthma control test scores and severe asthma. The rate of job change was markedly lower in the WEA subgroup than in the OA subgroup (20% vs. 5%). Conclusions: The overall prevalence of WRA (17%) was similar to those of previous studies, but the share of WEA was high (50% of WRA). WEA was more severe than OA or NWRA. The possible reason for this severity is ongoing workplace exposure.
Woori Jo,Byung Sun Min,Hee-Young Yang,Na-Hye Park,Kil-Soo Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
The incidence of myocardial infarction, among the causes of cardiovascular morbidity and mortality, is increasing globally. In this study, left ventricular (LV) dysfunction, including LV systolic and diastolic function, was investigated in a rat myocardial ischemia/reperfusion injury model with echocardiography. The homoisoflavanone sappanone A is known for its anti-inflammatory effects. Using echocardiography, we found that sappanone A administration significantly improved LV systolic and diastolic function in a rat myocardial ischemia/reperfusion injury model, especially in the early phase development of myocardial infarction. Based on myocardial infarct size, serum cardiac marker assay, and histopathological evaluation, sappanone A showed higher efficacy at the doses used in our experiments than curcumin and was evaluated for its potential to improve LV function.