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Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
Isabel Rivera,David M. Cauvi,Nelson Arispe,Antonio De Maio 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Alpha calcium channel blockers (CCB) are widely prescribed for the treatment of hypertension, including Nitrendipine (NTD). The anti-hypertension effect of NTD is related to binding and blocking the activity of the voltage-gated L-type calcium channels. These channels consist of four subunits (α1, α2/δ, γ and β subunits), localized in the plasma membrane. Methods: Cellular proliferation was determined by the XTT method and apoptosis was measured by flow cytometry. The expression of the α1c subunit (Cacna1c) of the voltage-gated L-type calcium channels was reduced by siRNA and assessed by quantitative RT-PCR. Results: NTD blocked the proliferation of murine neuroblastoma (N2a cells) and induced apoptosis in a concentration- dependent manner. A decrease in Cacna1c expression did not have a significant effect on NTD toxicity of N2a cells. Conclusion: NTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.
Comorbidity Between Anorexia Nervosa and Depressive Disorder: A Narrative Review
Maria Pilar Calvo-Rivera,Maria Isabel Navarrete-Páez,Isabel Bodoano,Luis Gutiérrez-Rojas 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.3
Objective Anorexia nervosa (AN) is a disorder with a significantly high prevalence. Affective disorders, including depressive disorder (DD), often coexist with this eating disorder (ED). In this review we will focus on its prevalence, associated vulnerability factors, clinical manifestations, possible etiological factors and its prognosis.Methods A bibliographic search was carried out in the PubMed database selecting those articles that approached the subject of comorbidity between AN and DD. The search was limited to articles published from January 1990 to December 2021.Results Of the 1891 abstracts reviewed, 33 studies met inclusion criteria. The prevalence of this comorbidity was extremely variable between studies, which exposed their heterogeneity. As to symptomatology this comorbidity presents itself with more severity, greater expression of psychological traits and greater cognitive impairment. Certain personality traits are postulated as vulnerability factors. Genetic factors such as neurochemicals seem to be involved in its pathogenesis.Conclusion The comorbidity between DD and ED have important influence in its symptomatic expression, severity and prognosis. Some of the analyzed studies provide consistent data, but there are others that are contradictory. It would be necessary to increase the number of studies and use a unified methodology.
Evaluation of Novel Platelet Polymorphisms in Stroke. Dichotomic Effect of rs5443 in GNB3
Constantino Martínez,Ana Isabel Antón,Agustina Bernal,María Luisa Lozano,Francisca Ferrer-Marin,Javier Corral,Juan Antonio Iniesta,Vicente Vicente,José Rivera 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.1
Personal Exposure to PM2.5 in the Massive Transport System of Bogotá and Medellín, Colombia
Maria Paula Castillo-Camacho,Isabel Cristina Tunarrosa-Grisales,Lina María Chacón-Rivera,Marco Andrés Guevara Luna,Luis Carlos Belalcázar Cerón 한국대기환경학회 2020 Asian Journal of Atmospheric Environment (AJAE) Vol.14 No.3
Recent studies have shown that public transport users can be exposed to high levels of pollution emitted from their own vehicles and nearby sources. The purpose of this research is to determine the personal exposure of passengers to PM2.5 inside the vehicles of the massive public transport of two of the main and more populated cities of Colombia, Bogotá and Medellín. TM (TransMilenio powered by diesel) and SITVA (electric and gas natural vehicles) were the systems studied. Were evaluated the integration of new vehicles with technologies Euro V and Euro VI in the TM system, the impact of the weekend effect on personal exposure into public transport(TM and SITVA), and the possible differences between personal exposure regarding the ways of the systems(mixed lane or exclusive lane for TM and SITVA). To measure PM2.5 levels, a DustTrak monitor previously calibrated was used. This measurement campaigns lasted for more than 80 hours and a mean of 17000 data of PM2.5 concentrations were obtained for each route. The personal dose was calculated based on the recorded data. The mean PM2.5 concentrations and personal dose found in the research for TM are 167 µg/m³ and 2.3 µg/min, respectively, while, for SITVA they are 41 µg/m³ and 0.53 µg/min, respectively. Therefore, SITVA users have a 5 times lower personal exposure to PM2.5 than TM users. It was also found that due to the poor proportion of new TM vehicles during the monitoring period, the personal exposure in the old vehicles and in the new ones is similar. In the case of SITVA, it was evidenced that the mixed lane contributes to a high personal exposure to PM2.5 than the exclusive one.