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ECM and GLR Based Multiuser Detection with I-CSI
Maio Antonio De,Episcopo Roberto,Lops Marco The Korea Institute of Information and Commucation 2005 Journal of communications and networks Vol.7 No.1
This paper deals with the problem of multiuser detection over a direct-sequence code-division multiple access (DS-CDMA) channel with incomplete channel state informations (I-CSI). We devise and assess two novel recursive detectors based on the expectation conditional maximization (ECM) algorithm and the generalized likelihood ratio (GLR) principle, respectively. Both receivers entail an affordable computational complexity. Moreover, the performance assessment, conducted via Monte Carlo techniques, shows that they achieve satisfactory performance levels and outperform linear detectors.
Risk factors for hospital mortality in intensive care unit survivors: a retrospective cohort study
Luiza Gabriella Antonio e Silva,Claudia Maria Dantas de Maio Carrilho,Thalita Bento Talizin,Lucienne Tibery Queiroz Cardoso,Edson Lopes Lavado,Cintia Magalhães Carvalho Grion 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.1
Background Deaths can occur after a patient has survived treatment for a serious illness in an intensive care unit (ICU). Mortality rates after leaving the ICU can be considered indicators of health care quality. This study aims to describe risk factors and mortality of surviving patients discharged from an ICU in a university hospital. Methods Retrospective cohort study carried out from January 2017 to December 2018. Data on age, sex, length of hospital stay, diagnosis on admission to the ICU, hospital discharge outcome, presence of infection, and Simplified Acute Physiology Score (SAPS) III prognostic score were collected. Infected patients were considered as those being treated for an infection on discharge from the ICU. Patients were divided into survivors and non-survivors on leaving the hospital. The association between the studied variables was performed using the logistic regression model. Results A total of 1,025 patients who survived hospitalization in the ICU were analyzed, of which 212 (20.7%) died after leaving the ICU. When separating the groups of survivors and non-survivors according to hospital outcome, the median age was higher among non-survivors. Longer hospital stays and higher SAPS III values were observed among non-survivors. In the logistic regression, the variables age, length of hospital stay, SAPS III, presence of infection, and readmission to the ICU were associated with hospital mortality. Conclusions Infection on ICU discharge, ICU readmission, age, length of hospital stay, and SAPS III score increased risk of death in ICU survivors.
Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
Isabel Rivera,David M. Cauvi,Nelson Arispe,Antonio De Maio 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Alpha calcium channel blockers (CCB) are widely prescribed for the treatment of hypertension, including Nitrendipine (NTD). The anti-hypertension effect of NTD is related to binding and blocking the activity of the voltage-gated L-type calcium channels. These channels consist of four subunits (α1, α2/δ, γ and β subunits), localized in the plasma membrane. Methods: Cellular proliferation was determined by the XTT method and apoptosis was measured by flow cytometry. The expression of the α1c subunit (Cacna1c) of the voltage-gated L-type calcium channels was reduced by siRNA and assessed by quantitative RT-PCR. Results: NTD blocked the proliferation of murine neuroblastoma (N2a cells) and induced apoptosis in a concentration- dependent manner. A decrease in Cacna1c expression did not have a significant effect on NTD toxicity of N2a cells. Conclusion: NTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.