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- 저자 : Iraj Karimi (검색결과 5 건)
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Vahid Khanjarsim,Jamshid Karimi,Iraj Khodadadi,Adel Mohammadalipour,Mohammad Taghi Goodarzi,Ghasem Solgi,Mohammad Hashemnia 전남대학교 의과학연구소 2017 전남의대학술지 Vol.53 No.2
Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL4. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-a and TGF-b mRNA expression were evaluated by quantitative RT-PCR. TNF-a protein levels were measured using the immunoassay method. Thiol groups, carbonyl groups, nitric oxide levels and glutathione peroxidase activity were measured by spectrophotometric methods.The results showed that Nilotinib decreased TNF-a, TGF-b, RAGE and HMGB1 mRNA expression (p<0.001) in the liver tissues of the fibrosis group. Nilotinib also decreased carbonyl groups and nitric oxide levels and increased thiol groups and glutathione peroxidase activity in the fibrosis groups. The histopathological changes were found to be attenuated by Nilotinib. In conclusion, Nilotinib can improve liver fibrosis and open new mechanisms of the anti-fibrotic properties of Nilotinib.
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Circulating Betatrophin Levels Are Associated with the Lipid Profile in Type 2 Diabetes
Hassan Ghasemi,Heidar Tavilani,Iraj Khodadadi,Massoud Saidijam,Jamshid Karimi 전남대학교 의과학연구소 2015 전남의대학술지 Vol.51 No.3
Betatrophin is a newly characterized circulating hormone that is produced in tissuessuch as adipose tissue and liver and stimulates pancreatic beta-cell proliferation. Thepurpose of the current study was to examine circulating betatrophin levels in Iranianpatients with type 2 diabetes mellitus (T2DM) and in normal controls. Seventy-five subjectswere enrolled in this case-control study in the following two groups: T2DM patients(n=40) and a group of age-, sex-, and BMI-matched normal control subjects (n=35). Circulating betatrophin concentrations as well as the blood lipid profile, body mass index(BMI), fasting blood sugar (FBS), glycated hemoglobin (HbA1c), and insulin resistancewere determined. Circulating betatrophin levels were significantly higher in patientswith T2DM than in the normal subjects (4.79±1.53 ng/mL vs. 2.79±1.11 ng/mLrespectively; p=0.001). Serum triacylglycerol and total cholesterol were also significantlyhigher in patients with T2DM than in the control group. In the patients withT2DM, serum betatrophin was positively correlated with age, FBS, TG, total cholesterol,and HbA1c. The results of this initial study in Iran have shown that circulating betatrophinlevels are significantly increased in Iranian patients with T2DM comparedwith a control group. Additionally, it is postulated that betatrophin as a novel hormonemay be involved in the generation of an atherogenic lipid profile.
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Mehran Alavi,Naser Karimi,Iraj Salimikia 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.72 No.-
It was used green biosynthesized zinc oxide (ZnO) NPs (average diameter of 50–60 nm) with abilities of antibacterial against sensetive and MDR bacteria including Escherichia coli ATCC 25922, Serratia marcescens ATCC13880, Pseudomonas aeruginosa ATCC 27853 (gram negative), and Staphylococcus aureus ATCC 43300 and Staphylococcus epidermidis ATCC 12258 (gram positive). High reduction in biofilm formation was 63.43% (0.562 ± 0.015) and 62.88% (0.582 ± 0.025) at 100 μg/mL concentration against control for S. epidermidis and P. aeruginosa respectively. In conclusion, this investigation illustrated simple green synthesis of ZnO NPs with suitable advantages of antioxidant, antibacterial, anti-biofilm, anti-QS activities, and also anti-swarming motility against MDR bacteria.
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Rezaei, Ali Akbar,Salehi, Iraj,Karimi, Seyed Asaad,Rahnama, Mehdi The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.1
Objective: The strong antioxidant activity of Commiphora mukul prompted us to conduct the present study to explore whether treatment with C. mukul extract (CME) would have any protective influence on sperm parameters, testosterone levels, and plasma glucose levels in streptozotocin (STZ)-induced diabetic rats. Methods: Male Wistar rats were randomly divided into four groups: control, control animals treated with CME, diabetic animals, and diabetic animals treated with CME. CME extract (300 mg/kg) was administered for 60 days by daily gavage. Diabetes was induced by an intraperitoneal injection of 50 mg/kg STZ. The epididymal sperm count, weight, motility, morphology, viability, and serum testosterone and glucose levels were determined. Results: In the diabetic animals, CME decreased blood glucose levels (p< 0.05), increased the total sperm count (p< 0.05), and decreased the proportion of sperm with abnormal morphology (p< 0.05). Diabetes reduced sperm motility (p< 0.001), and CME supplementation partially reversed this effect of diabetes (p= 0.003). Furthermore, in diabetic animals, CME decreased the proportion of immotile sperm (p< 0.001). In rats, diabetes caused a significant decrease (p< 0.05) in serum testosterone levels (F[3, 28] = 3.283, p= 0.035), but treatment of diabetic animals with CME increased serum testosterone levels. Conclusion: The present study demonstrated that C. mukul possesses proandrogenic activity and exerts a beneficial effect on sperm parameters in diabetic rats.
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Amin Bigham-Sadegh,Iraj Karimi,Mahsa Alebouye,Zahra Shafie-Sarvestani,Ahmad Oryan 대한수의학회 2013 Journal of Veterinary Science Vol.14 No.3
The present study was conducted to compare the effects of xenogenic bovine fetal demineralized bone matrix (DBM),commercial DBM, omentum, omentum-calf fetal DBM,cortical autograft and xenogenic cartilage powder on the healing of tibial defects in a dog model to determine the best material for bone healing. Seven male adult mongrel dogs,weighing 26.2 ± 2.5 kg, were used in this study. Seven holes with a diameter of 4-mm were created and then filled with several biomaterials. Radiographs were taken postoperatively on day 1 and weeks 2, 4, 6, 8. The operated tibias were removed on the 56th postoperative day and histopathologically evaluated. On postoperative days 14, 42 and 56, the lesions of the control group were significantly inferior to those in the other group (p < 0.05). On the 28th postoperative day, the autograft group was significantly superior to the control and omentum groups (p < 0.05). Moreover, calf fetal DBM was significantly superior to the control group. There was no significant difference between the histopathological sections of all groups. Overall, the omentum and omentum-DBM groups were superior to the control group, but inferior to the autograft, commercial-DBM, calf fetal DBM and calf fetal cartilage groups.
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