http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Inge Seim,Adrian C. Herington,Lisa K. Chopin 한국유전학회 2010 Genes & Genomics Vol.32 No.5
Transposable elements, which are DNA sequences that can move between different sites in genomes, comprise approximately 40% of the genome of mammals and are emerging as important contributors to biological diversity. Here we report a transcription unit lying within intron 1 of the murine Magi1(membrane associated guanylate kinase inverted 1) gene that codes for a cell-cell junction scaffolding protein. The transcription unit, termed Magi1OS (Magi1 Opposite Strand), originates from a region with tandem B1 short interspersed nuclear elements (SINEs) and is an antisense gene to Magi1. Mag1OS transcription initiates in a proximal B1 element that shows only 4% divergence from the consensus sequence, indicating that it has been recently inserted into the mouse genome and could be replication competent. Moreover, a chimaeric transcript may result from intra-chromosomal interaction and trans-splicing of the Magi1 antisense transcript (Magi1OS) and Ghrl, which codes for the multifunctional peptide hormone ghrelin. These two genes are 20 megabases apart on chromosome 6 and are transcribed in opposite directions. We propose that the Magi1OS locus may serve as a useful model system to study exaptation and retrotransposition of B1 SINEs, as well as to examine the mechanisms of intra-chromosomal trans-splicing.
Poster Session:PS 0524 ; Nephrology : Resistant Hypertension and Renal Denervation
( Inge Ingrid Prkacin ),( Dario Kizul ),( Iva Klara Pranjic ),( Vinko Vidjak ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Hypertension control requires joint efforts of the community, including patients themselves, their community and family physicians. Increased activation of the sympathetic nervous system is identifi ed as an important factor in the development and progression of hypertension. In this context has been developed catheter-based approach to disrupt the renal sympathetic nerves-renal denervation (RDN). Among patients with resistant hypertension it is very important to select patients most likely to have benefi t from RDN, because thay represent a very mixed group of diagnoses. Methods: RDN was performed in 7 patients using standard radiofrequency system with ablation catheter (5F system/6F guide catheter; SymplicityTM RDN System) inserted through the femoral artery, engaging the renal artery bilaterally. five nerve ablations of 100 second duration on each side were performed without any complications. Offi ce BP measurements at 1, 3 and 6 months folow-up visits were compared to baseline values. We used STATISTIKA 10, 2011 software, statistically signifi cant if p<0.001. Results: From 100 patients referred because of resistant hypertension more than twothirds of the patients (76%) did not meet the criteria of refractory resistant, or had a secondary form of hypertension (17%). Only 7 (7%) have criteria for RDN: at baseline, values were 62± 6 years, 184/106± 21/26 mmHg, 6.7±1 for number of antihypertensive drug classes. One, 3 and 6 months after procedure, only offi ce systolic BP were signifi - cantly lower (144± 13, 140 ± 17, 141± 15 mmHg, p<0.001). Six months after procedure the number of antihypertensive drug classes required was 6.5 ±1, with proteinuria amelioration in patient with type 2 diabetes (4 patients) and stabile chronic kidney disease (CKD stage 3). Conclusions: The patients with type 2 diabetes and CKD may be the target population that would substantially benefi t from RDN. Further randomized clinical trials could be benefi cial in improving both renal and cardiovascular outcomes.
Genetic radiation risks: a neglected topic in the low dose debate
Inge Schmitz-Feuerhake,Christopher Busby,Sebastian Pflugbeil 환경독성보건학회 2016 환경독성보건학회지 Vol.31 No.-
Objectives To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. The value is based on experiments on mice due to reportedly absent effects in the Japanese atomic bomb (Abomb) survivors. Methods To review the published evidence for heritable effects after ionising radiation exposures particularly, but not restricted to, populations exposed to contamination from the Chernobyl accident and from atmospheric nuclear test fallout. To make a compilation of findings about early deaths, congenital malformations, Down’s syndrome, cancer and other genetic effects observed in humans after the exposure of the parents. To also examine more closely the evidence from the Japanese A-bomb epidemiology and discuss its scientific validity. Results Nearly all types of hereditary defects were found at doses as low as one to 10 mSv. We discuss the clash between the current risk model and these observations on the basis of biological mechanism and assumptions about linear relationships between dose and effect in neonatal and foetal epidemiology. The evidence supports a dose response relationship which is non-linear and is either biphasic or supralinear (hogs-back) and largely either saturates or falls above 10 mSv. Conclusions We conclude that the current risk model for heritable effects of radiation is unsafe. The dose response relationship is non-linear with the greatest effects at the lowest doses. Using Chernobyl data we derive an excess relative risk for all malformations of 1.0 per 10 mSv cumulative dose. The safety of the Japanese A-bomb epidemiology is argued to be both scientifically and philosophically questionable owing to errors in the choice of control groups, omission of internal exposure effects and assumptions about linear dose response.
Wangkarra: communication and the verbal arts of Australia’s Western Desert
Inge Kral,Jennifer Green,Elizabeth Marrkilyi Ellis 국립민속박물관 2019 International Journal of Intangible Heritage Vol.14 No.-
In this paper we situate the verbal arts of the Ngaanyatjarrapeople of the Western Desert of Australia within thediscourse surrounding the UNESCO concept of IntangibleCultural Heritage. We describe the rich heritage of oraltraditions that exist in the Ngaanyatjarra region, how theyemerged, how they are being sustained and the forcesof change that reveal their fragile state today. We givean account of the Western Desert Verbal Arts Project, adocumentation project that has, since 2010, collected,recorded and archived a spectrum of practices includingoral narratives, sand storytelling, alternate sign languageand special speech styles. These practices are embeddedin a speech community where the everyday indigenousspoken language is also considered endangered. Weconsider ways to not only safeguard these rarefied andextremely fragile verbal arts traditions, but also to bringthem to the fore as an integral aspect of the living heritageof the Ngaanyatjarra people.
Leif Inge Tjelta,Asle Rønning Tjelta 국민체육진흥공단 한국스포츠정책과학원 2012 International Journal of Applied Sports Sciences Vol.24 No.1
The purpose of the present study is to describe the relationships between running velocity at anaerobic threshold (vAT) and maximal oxygen uptake (VO_(2max)), running economy (RE) and the fractional utilization of VO_(2max) at vAT (%VO_(2max)) in elite runners. vAT tests and VO_(2max) tests were conducted on 34 Norwegian distance runners (22 males, 12 females) included in this study. Subjects completed between one and six tests each. The vAT test was assessed by treadmill running using a stepwise incremental protocol. vAT was defined as the running pace where blood lactate concentration [La-] was 1.5 mmol․L^(-1) above warm up value. RE was set to be VO_2 ml․kg^(-1)․km^(-1). Standard multiple regression analysis showed that 89% of vAT could be predicted by VO_(2max), RE and % VO_(2max) (n=34). There were, however, no significant correlations between vAT and any of the variables VO_(2max), RE and % VO_(2max) in women, while VO_(2max) was significantly correlated with vAT in men. This study indicates that in a group of elite runners, VO_(2max) is the variable that most affects vAT among men. Among women, rather surprisingly, no significant correlations between vAT and any of the variables: VO_(2max),RE and % VO_(2max) were found. This might be explained by large individual differences that to a certain extent equalize each other.