Corrigendum to: Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe

Mohamed Ali Metwally,El-Yamani Ibrahim El-Zawahry,Maher Amer Ali,Diaa Farrag Ibrahim,Shereen Ahmed Sabry,Omnia Mohamed Sarhan 대한생리학회-대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.4

Physicochemical and photo-electrochemical characterization of novel N-doped nanocomposite ZrO₂/TiO₂ photoanode towards technology of dye-sensitized solar cells

Mohamed, Ibrahim M.A.,Dao, Van-Duong,Yasin, Ahmed S.,Mousa, Hamouda M.,Yassin, Mohamed A.,Khan, Muhammad Yasir,Choi, Ho-Suk,Barakat, Nasser A.M. Elsevier 2017 Materials characterization Vol.127 No.-

<P><B>Abstract</B></P> <P>This work introduces the synthesis of N-doped nanocomposite of ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> nanofibers (NFs) by use of both electrospinning and hydrothermal methods. The physicochemical properties of the introduced TiO<SUB>2</SUB> NFs are investigated to describe the morphology, crystallinity and chemistry through FESEM, SEM-EDX, XRD, TEM and XPS. As the results, the investigated material can be described as N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs. The crystal structure of the prepared TiO<SUB>2</SUB> is only anatase structure. Then, the novel NFs are utilized to design novel photoanode and photo-electrochemical characterization such as current-potential response under light, incident photon-to-current efficiency (IPCE) and electrochemical impedance spectroscopy (EIS) of the dye-sensitized solar cell (DSC) are also investigated. The photovoltaic response showed that the efficiency of the DSCs employed N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> photoanode gave 4.95%, which was higher than those of DSCs designed with ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs (4.51%) and N@TiO<SUB>2</SUB> NFs (4.41%) photoanodes. The high photo-response of DSC by use of N@ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs can be attributed to enhanced electrical conductivity, which is studied via EIS, and presence of active sites of N. These active sites can easily absorb dye-molecules in the step of dye-loading in the fabrication of DSC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-doped ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> nanofibers (NFs) are synthesized via facile two steps; electrospinning followed by hydrothermal. </LI> <LI> The produced NFs have only anatase crystal structure. </LI> <LI> 4.95% PV efficiency was achieved by the synthesized NFs. </LI> <LI> DSC based on N-doped ZrO<SUB>2</SUB>/TiO<SUB>2</SUB> NFs shows high electrical conductivity and low charge transfer resistance; 9.375Ω. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Efficacy of Nile tilapia (Oreochromis niloticus) juveniles and spinosyns bioinsecticides against aquatic stages of Culex pipiens: An experimental study

Mohamed Ibrahim A.,Fathy Mohamed,Farghal Ahmed I.A.,Temerak Sobhy A.H.,Sayed Alaa El-Din H. 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

The mosquito Culex pipiens is the most widely distributed dipteran species in all regions of Egypt and the principal vector of Wuchereria bancrofti and certain arboviruses in human beings. For controlling C. pipiens vector, biological tools (e.g., larvivorous fish and bioinsecticides) are more potent and safer options to the environment, human beings, and beneficial organisms than chemical pesticides. The efficiency of O. niloticus juveniles as predatory fish species and two bioinsecticides, spinosad 24% and spinetoram 12%, was investigated against the C. pipiens developmental stages in the laboratory. The first trial evaluated the predatory efficacy of small-sized O. niloticus (2.1–2.6 cm; 250–315 mg) and large-sized O. niloticus (2.5–3.2 cm; 250–315 mg) against the 3rd larvae and pupae of C. pipiens. This is the first report in Egypt confirming the predation potential of O. niloticus as efficient predatory fish against the immature C. pipiens. Large-sized O. niloticus predated a greater number of 3rd of C. pipiens larvae and pupae than the small-sized ones. Furthermore, the daily consumption of C. pipiens larvae by small- and large-sized O. niloticus was significantly higher than the pupae. The second trial assessed the toxicity efficacy of spinosad 24% and spinetoram 12% against C. pipiens larvae and pupae. The results confirmed that the tested bioinsecticides showed higher potency toward C. pipiens larvae than pupae after exposure for 24 h and 48 h. Spinosad was more toxic toward 3rd C. pipiens larvae (LC 50 = 0.013 and 0.003 mg/L) and pupae (LC 50 = 320.69 and 44.28 mg/L) than spinetoram after 24 and 48 h. Herein, O. niloticus juveniles (as promising native predatory fish) and spinosyns bioinsecticides were more effective against C. pipiens in the larval stage than in the pupal stage. In conclusion, Nile tilapia juveniles and biorational compounds, spinosad 24% and spinetoram 12%, might be considered as promising and favorable environmental biological agents for controlling C. pipiens in Egypt. However, further trials are needed to investigate the potential of these agents in the control of this mosquito vector under field conditions.

Calcium hydroxide intracanal medication effects on pain and flare-up: a systematic review and meta-analysis

Ibrahim, Ahmed Mohamed,Zakhary, Siza Yacoub,Amin, Suzan Abdul Wanees The Korean Academy of Conservative Dentistry 2020 Restorative Dentistry & Endodontics Vol.45 No.3

Objectives: This study aimed to systematically review the pain and flare-up effects of calcium hydroxide (CH) as intracanal medication (ICM) in non-vital mature teeth. Materials and Methods: Electronic-databases searching for published and grey literature and manual searching were conducted. Only randomized clinical trials (RCTs) were included comparing CH to other ICMs in non-vital mature teeth. The risk of bias was assessed using the RoB 2.0 Cochrane tool. The main outcomes were pain and flare-up. Qualitative and quantitative analysis, wherever applicable, was performed. The certainty of evidence (CoE) was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: Sixteen articles were included in 6 comparisons at different time points for different outcomes. CH reduced pain risk than no ICM within the 1-14-days interval (p < 0.05) and than triple-antibiotic paste within the first day (p < 0.05) and was similar to corticosteroid/antibiotics combination (p > 0.05). Chlorhexidine (CHX) or CH/CHX, however, reduced pain levels than CH alone (p < 0.05). CH showed higher flare-up risk than CHX (p < 0.05). CoE, however, ranged from very low to moderate. Conclusion: Most comparisons for different outcomes are based on very few studies, mostly low-powered, with an overall low CoE. Thus, the available evidence is considered insufficient to either support or refute CH effectiveness or to recommend one ICM over another. Therefore, further well-designed, larger RCTs are required.

Palatal vault configuration and its influence on intraoral scan time and accuracy in completely edentulous arches: a prospective clinical study

Dina Mohamed Ahmed Elawady,Wafaa Ibrahim Ibrahim,Radwa Gamal Ghanem,Reham Bassuni Osman 대한치과보철학회 2024 The Journal of Advanced Prosthodontics Vol.16 No.4

Purpose. The aim of this prospective clinical study was to compare the influence of palatal vault forms on accuracy and speed of intraoral (IO) scans in completely edentulous cases. Materials and methods. Based on the palatal vault form, participants were divided into three equal groups (n = 10 each); Class I: moderate; Class II: deep; Class III: flat palatal vault. A reference model was created for each patient using polyvinylsiloxane impression material. The poured models were digitized using an extraoral scanner. The resultant data were imported as a solid CAD file into 3D analysis software (GOM Inspect 2018; Gom GmbH, Braunschweig, Germany) and aligned using the software’s coordinate system to determine its X, Y, and Z axes. Five digital impressions (DIs) of maxilla were captured for each patient using an intraoral scanner (TRIOS; 3Shape A/S, Copenhagen, Denmark) and the resultant Standard Tessellation Language (STL) scan files served as test models. Trueness was evaluated by calculating arithmetic mean deviation (AMD) of the vault area between reference and test files while precision was evaluated by calculating AMD between captured scans to measure repeatability of scan acquisition. The scan time taken for each participant was also recorded. Results. There was no significant difference in trueness and precision among the groups (P = .806 and .950, respectively). Average scan time for Class I and III palatal vaults was 1 min 13 seconds and 1 min 37 seconds, respectively, while class II deep palatal vaults showed the highest scan time of 5 mins. Conclusion. Palatal vault form in edentulous cases has an influence on scan time. However, it does not have a substantial impact on the accuracy of the acquired scans.

Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe

Metwally Mohamed Ali,El-Zawahry El-Yamani Ibrahim,Ali Maher Amer,Ibrahim Diaa Farrag,Sabry Shereen Ahmed,Sarhan Omnia Mohamed 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3

Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181–0.72) and (–13.4 to –6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.

Geochemical, multi-isotopic studies and geothermal potential evaluation of the complex Djibouti volcanic aquifer (republic of Djibouti)

Awaleh, Mohamed Osman,Boschetti, Tiziano,Soubaneh, Youssouf Djibril,Kim, Yongje,Baudron, Paul,Kawalieh, Ali Dirir,Ahmed, Moussa Mahdi,Daoud, Mohamed Ahmed,Dabar, Omar Assowe,Kadieh, Ibrahim Houssein,A Elsevier 2018 Applied geochemistry Vol.97 No.-

<P><B>Abstract</B></P> <P>The complex Djibouti volcanic aquifer system was studied to improve understanding of the recharge conditions of the Awrlofoul low-enthalpy geothermal system located in the middle of the aquifer. Forty-four thermal and non-thermal groundwater samples were analyzed to determine their major chemical compositions, trace element compositions, and multi-isotopic compositions (δ<SUP>2</SUP>H(H<SUB>2</SUB>O), δ<SUP>18</SUP>O(H<SUB>2</SUB>O), δ<SUP>18</SUP>O(SO<SUB>4</SUB>), δ<SUP>34</SUP>S(SO<SUB>4</SUB>), δ<SUP>13</SUP>C(DIC), <SUP>14</SUP>C, <SUP>87</SUP>Sr/<SUP>86</SUP>Sr, δ<SUP>11</SUP>B, δ<SUP>15</SUP>N(NO<SUB>3</SUB> <SUP>−</SUP>), and δ<SUP>18</SUP>O(NO<SUB>3</SUB> <SUP>−</SUP>)). Statistical analysis (Hierarchical Cluster Analysis and Principal Component Analysis) of chemical composition identified three main water groups, two affected by salinization (C1 and C2) and one fresh water group useful for drinking (C3). The latter group includes thermal water from the Awrlofoul geothermal field. This separation into three different water groups is also clear on a Langelier-Ludwig plot and is confirmed by analysis of historical chemical data over the last 30 years. The main causes of salinization are contamination of the fresh groundwater either by recent seawater intrusions (C2) or mixing with Ca-Cl fossil saline water (C1). The C1 waters are also highly affected by Mg/Ca-Na clay exchange. As expected, the <SUP>11</SUP>B/<SUP>10</SUP>B isotope ratio of the intruded salt water, both recent and fossil, was much higher than that of seawater (δ<SUP>11</SUP>B up to +55‰). Unexpectedly, groundwater of meteoric origin (i.e., unaffected by a seawater intrusion), also showed a δ<SUP>11</SUP>B higher than that of seawater (46.3‰ < δ<SUP>11</SUP>B < 51.3‰). That the unexpectedly high δ<SUP>11</SUP>B values are likely due to <SUP>10</SUP>B sequestration resulting from interaction with clay and/or carbonate precipitation is demonstrated by activity diagrams and saturation indices. The C1 water group is also affected by nitrate contamination (56.8 ± 19.2 mg/l). That the nitrate contamination is likely due to manure contamination is indicated by comparing the dual isotopic composition of nitrate to the boron isotope ratios. The isotopic composition of sulfate highlighted the importance of SO<SUB>2</SUB>-disproportionation to the local sulfate minerals that interacted with the meteoric recharge, while the strontium isotope ratios showed the importance of the seawater-basalt interaction with the fossil saline water component. The results of the mixing analysis using chemical composition, δ<SUP>13</SUP>C(DIC), and <SUP>14</SUP>C data by geochemical software (NetpathXL) confirmed the presence of ternary mixing with at least three sources (seawater, meteoric, and fossil) in the waters with the highest chloride concentrations. The estimation of groundwater age by <SUP>14</SUP>C was complicated by overexploitation (as testified by the lumped parameters approach). However, the fossil saline water component was dated back to the Holocene Humid Period.</P> <P>To estimate the temperature of the Awrlofoul low-enthalpy geothermal system, a multi-method geothermometric approach was applied. Chemical (mainly SiO<SUB>2</SUB>) and isotope (sulfate-water oxygen fractionation) geothermometers were employed together with multiple mineral equilibria. These different geothermometric approaches estimated a temperature range of 102 °C–140 °C for the geothermal reservoir, with a mean temperature of about 110 °C.</P> <P>Finally, a conceptual model was proposed for the Awrlofoul low-enthalpy geothermal system on the basis of the geochemical and isotopic data of the thermal and non-thermal groundwaters combined with the geology and hydrogeology of the study area.</P> <P><B>Highlights</B></P> <P> <UL> <LI>

Analysis of Composition and Diversity of Natural Regeneration of Woody Species in Jebel El Gerrie Dry Land Forest East of Blue Nile State, Sudan

Abuelbashar, Ahmed Ibrahim,Ahmed, Dafa-Alla Mohamed Dafa-Alla,Siddig, Ahmed Ali Hassabelkreem,Yagoub, Yousif Elnour,Gibreel, Haithum Hashim Institute of Forest Science 2022 Journal of Forest Science Vol.38 No.2

The study aims to assess composition, diversity and population indices of natural regeneration of woody species in Jebel El Gerrie forest reserve, Blue Nile State, Sudan. We conducted field work between December 2018 and January 2019. We used random sampling to collect vegetation data in the forest where we made a total of 90 circular sample plots (radius 17.84 m) and distributed them proportionally to the area of each of the four density-based vegetation classes of the forest i.e. high density (C1), medium density (C2), low density (C3) and crop land (C4). In each sample plot we identified all regenerating tree species and counted their regeneration frequencies. We calculated ecological metrics of regeneration frequency, density, abundance, richness, evenness, diversity and importance value index (IVI) and drew abundance rank curve. Results revealed that out of fifteen mature tree species present, natural regeneration of 8 species, which belong to 6 families, was observed. The relatively most frequently naturally regenerating and abundant species were Anogeissus leiocarpa and Combretum hartmannianum. Richness, evenness and diversity of regenerating species were 1.33, 0.82 and 1.7, respectively. One-way ANOVA (α=0.05) of mean regeneration densities disclosed that there were significant differences (F_3,86=16.77, p=0.000) between C2 & C3 (p=0.000) and C2 & C4 (p=0.000). While regeneration of seven tree species were absent, two, two and four species were of good, poor and fair regeneration status, respectively. A comparison of mean density of natural regeneration with that of parent trees reflects a poor regeneration status of the forest. The study provides empirical results on the regeneration status of species and signifies the need for management interventions for species conservation and restoration, maintenance of biodiversity and sustainable production.

Theoretical insight into the structure-property relationship of mixed transition metal oxides nanofibers doped in activated carbon and 3D graphene for capacitive deionization

Yasin, Ahmed S.,Mohamed, Ahmed Yousef,Mohamed, Ibrahim M.A.,Cho, Deok-Yong,Park, Chan Hee,Kim, Cheol Sang Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.371 No.-

<P><B>Abstract</B></P> <P>Over the last two decades, the capacitive deionization (CDI) technique has been developed into a high performance, low-cost, and environmental-friendly desalination technology. The development of novel advanced nanostructures via the hybridization of diverse carbon materials to improve the performance of CDI technology has attracted considerable attention. In this study, the combination of graphene hydrogel and ZrO<SUB>2</SUB>-doped TiO<SUB>2</SUB> nanofibers as efficient dopants into activated carbon (AC), has been achieved through a simple electrospinning technique followed by a post annealing process. The strong interactions between the graphene hydrogel, nanofibers and AC were found to enhance the wettability as well as the electrical conductivity of the AC. The morphology and electrochemical performance of the as-synthesized composite were characterized by field-emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). What’s more, the X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and synchrotron X-ray absorption structures (XAS) are performed to investigate the atomic and electronic structure of titania and zirconia in order to understand their phase stability. We observed the appearance of anatase structure of titania and cubic structure of zirconia after doping the AC and graphene hydrogel with the nanofibers. The water contact angle of the composite was examined and found to be less than 3°. The introduced nanocomposite showed high electrosorption capacity of 9.34 mg g<SUP>−1</SUP> at the initial solution conductivity of ∼100 μS cm<SUP>−1</SUP>, which is much higher compared to the other surveyed materials; these results should be attributed to its significant hydrophilicity, high specific capacitance, and reduced charge transfer resistance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Unique three-dimensional graphene/mixed transition metal oxides modified activated carbon was prepared and characterized. </LI> <LI> The nanocomposite electrode shows low charge transfer resistance and high specific capacitance. </LI> <LI> Analysis of synchrotron-based hard X-ray absorption spectroscopy. </LI> <LI> The fabricated nanocomposite exhibits a high electrosorption capacity of 9.34 mg g<SUP>−1</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Assessing Trees Diversity in Jebel Elgarrie Forest Reserve in the Blue Nile State, Sudan

Dafa-Alla Mohamed Dafa-Alla,Ahmed Ibrahim Abuelbasher,Haytham Hashim Gibreel,Yousif Elnour Yagoub,Ahmed Ali Hassabelkreem Siddig,Ahmed Mustafa Morad Hasoba 강원대학교 산림과학연구소 2022 Journal of Forest Science Vol.38 No.3

The study aims to examine population indices of mature trees in Jebel Elgarrie forest, Blue Nile State, Sudan. We used remote sensing techniques to stratify the forest into vegetation classes depending on tree density. We distributed 97 circular sample plots (0.1 ha) proportionally to the area of the vegetation classes. In each sample plot we identified, counted and recorded all mature trees (DBH ≥10 cm). We calculated frequency, density, abundance, richness, evenness and diversity for each species and we drew abundance rank curve of mature trees. We used One-Way ANOVA to test for differences (=0.05) in mean density (No./ha) of mature trees between vegetation classes. Results revealed that the forest was conveniently sub-divided into high density (C1), medium density (C2), low density (C3) and bare farm land (C4) classes. We identified fifteen tree species that belong to 10 families and 14 genera. Combretaceae and Fabaceae were the common families while Anogeissus leiocarpa was the most frequently occurring species. While species diversity varied between vegetation classes, diversity of the forest as a whole is low. While mean density of mature trees in C1, C2, C3 and C4 it was 100, 74, 10, and 0, respectively, it was 54 for the whole forest indicating low stocking, Following One-Way ANOVA, multiple comparisons revealed significant differences in mean density of mature trees between C1 & C3 and C2 & C3. The study provided empirical results on population indices of mature tree species, which would be of importance for successful management and conservation of the forest.