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Anti-Inflammatory Effects of Rutin on LPS-Induced Responses in Canine macrophage, DH-82 Cells
Hyunsoo Jang(장현수),Jisu Lee(이지수),Su-Cheol Han(한수철),Ha-Young Shin(신하영),Dahyun Kang(강다현),Su Jeong Kim(김수정),Yeon Woo Kim(김연우),조민서,Jeong Ho Hwang(황정호),Jung-Heun Ha(하정헌) 한국지역사회생활과학회 2024 한국지역사회생활과학회 학술대회 자료집 Vol.2024 No.6
Determination of the optimal time for tamoxifen treatment in combination with radiotherapy
Jang, Hyunsoo,Baek, Junyoung,Nam, Kyung-Soo,Kim, Soyoung Spandidos Publications 2016 International journal of oncology Vol.49 No.5
<P>Although radiotherapy and tamoxifen have been extensively used to treat estrogen receptor a (ER alpha)-positive breast cancers, it is still questionable when tamoxifen should be started to maximize clinical benefits in combination with radiotherapy. Generally, clinician's opinion and experience are major determinants in scheduling concurrent or sequential tamoxifen and radiotherapy. Thus, we attempted to determine an optimal time to start tamoxifen treatment by analyzing tamoxifen responses at different times after irradiating MCF-7 cells to cumulative doses of 10 or 20-30 Gy. MCF-7 cells were irradiated with 5 Gy a week, twice (a cumulative dose of 10 Gy) followed by a period of recovery. MTT viability assay for tamoxifen was done with MCF-7 cells harvested immediately after each 5 Gy (MCF-7-5 Gy) or 10 Gy (MCF7-10 Gy) irradiation or after subsequent culture of surviving MCF-7-10 Gy cells for 40 days (MCF-7-Rl). To establish the radioresistant cells, the above cycles of irradiation were repeated for a cumulative dose of 20 Gy (MCF-7-R2) or 30 Gy (MCF-7-R3). In addition, cytotoxic effects of tamoxifen were also measured. Attenuated tamoxifen response was observed in MCF-7-5 Gy and 10 Gy cells, whereas the efficacy of tamoxifen was restored in MCF-7-R1 cells. Furthermore, these responses to tamoxifen correlated with ERa expression. However, the radioresistant MCF-7 cells (MCF-7-R2/R3) exhibited resistance to tamoxifen without change in ER expression, but the phosphorylation of AKT was increased. Taken together, our data suggest that sequential tamoxifen treatment following radiotherapy is more effective than concurrent treatment. Furthermore, the reduced efficacy of tamoxifen on radioresistant cells indicates that an additional targeted therapy, such as AKT inhibitor treatment, is required to improve tamoxifen response in radioresistant breast cancer.</P>
장현수(Hyunsoo Jang),강승희(Seung-Hee Kang),이선영(Sunyoung Lee),조선미(Sun Mi Jo),오영택(Young Taek Oh),전미선(Mison Chun),최진혁(Jin Hyuk Choi),강석윤(Seok Yun Kang) 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.2
목 적: 동시적 항암화학방사선치료를 받은 식도암 환자의 치료성적과 예후인자를 분석하였다. 대상 및 방법: 1994년 1월부터 2007년 7월까지 식도암으로 방사선치료를 받은 환자 246명 중 근치적 목적으로 45Gy이상의 방사선치료와 함께 동시적 항암화학요법을 받았으며 생존확인이 가능하였던 78명을 대상으로 후향적 분석을 시행하였다. AJCC 병기 IIA∼IVB까지의 환자를 대상으로 하였는데, IVB는 상부식도암이 아닌 환자에서 쇄골상부림프절 전이가 있거나 하부식도암이 아닌 환자에서 복강림프절 전이가 있는 경우만을 포함시켰다. 방사선치료는 중앙값 54 Gy를 조사하였고, 항암화학요법은 대부분의 환자(88%)에서 5-FU와 cisplatin (FP) 병합요법으로 시행되었다. 추적관찰기간은 2∼117개월(중앙값 14개월)이었다.결 과: 흉부단층촬영이나 식도내시경을 통해 치료에 대한 반응을 확인할 수 있었던 54명의 환자중 완전관해가 17 명, 부분관해가 18명이었다. 완전관해를 보인 환자에서 재발할 때까지의 기간은 중앙값 20개월이었고 첫 재발부위로 국소재발이 3명, 원격전이가 7명이었다. 1년, 2년, 5년 전체 생존률은 각각 58.9%, 21.7%, 12.2%이었고 중앙생존기간은 14개월이었다. 전체 생존률에 대한 단변량분석에서 치료에 대한 반응과 FP병합요법의 횟수가 통계적인 유의성을 보여주었다. 환자의 숫자가 적었으나 방사선감작제로 일단위 혹은 주단위의 cisplatin이 FP 병합요법보다 좋은 결과를 보였다. 결 론: 원격장기로의 전이가 없는 국소진행성 식도암 환자에서 동시적 항암화학방사선치료는 기존의 연구와 유사한 결과를 보여주었다. 일단위 혹은 주단위의 cisplatin이 전신상태가 FP 병합요법에 적절하지 않은 환자에서 대안으로 사용될 수 있을 것으로 생각된다. Purpose: We investigated the outcome and the prognostic factors of patients with locally advanced esophageal cancer who were treated with concurrent chemo-radiotherapy. Materials and Methods: Two hundred forty six patients with esophageal cancer that were treated by radiotherapy between January 1994 and July 2007. Of these, 78 patients who received radiotherapy of ≥45 Gy with concurrent chemotherapy were retrospectively enrolled in this study. We included patients stages IIA, IIB, III, IVA, and IVB with supraclavicular metastasis in the middle/lower esophageal cancer or celiac node metastasis in cervical or upper/middle thoracic esophageal cancer. The median radiation dose was 54 Gy and the combination chemotherapy with 5-FU and cisplatin (FP chemotherapy) was given concurrently with radiotherapy in most patients (88%). Results: The follow-up period ranged from 2 to 117 months (median 14 months). The treatment response of the 54 patients could be evaluated by computerized tomography or endoscopy. A complete response (CR) was observed in 17 patients, whereas a partial response was observed in 18 patients. In patients with a CR, the median recurrence time was 20 months and the first relapse sites constituted a locoregional failure in 3 patients and a distant failure in 7 patients. The 1-, 2-, and 5-year overall survival (OS) rates were 58.9%, 21.7%, and 12.2%, respectively. The median survival period was 14 months. A univariate analysis indicated that the treatment response and cycles of FP chemotherapy were significant prognostic factors for OS. Daily or weekly administration of cisplatin as a radiosensitizer showed a better treatment response than FP chemotherapy. Conclusion: This study has shown that results of concurrent chemo-radiotherapy in patients with locally advanced esophageal cancer is comparable to those of other studies. Daily or weekly cisplatin administration may be considered as an alternative treatment in patients that are medically unfit for FP chemotherapy.
맥도날드에서의 사용자 대기 경험 개선 방향 연구 -키오스크 화면 내 마이크로 인터랙션을 이용한 화면 밖으로의 시선 이동 유도를 중심으로-
장현수(Hyunsoo Jang),김선호(Sunho Kim),김현진(Hyunjin Kim),이시현(Sihyun Lee),최수빈(Soobin Choi),연명흠(MyeongHeum Yeoun) 한국HCI학회 2022 한국HCI학회 학술대회 Vol.2022 No.2
비대면 경험이 일반화되어 가고 있는 현대 사회에서 키오스크에 대한 개선이 많이 이루어지고 있다. 그러나 비대면 전환으로 인해 바뀌고 있는 것은 [주문/결제] 뿐만이 아니다. 본 연구에서는 맥도날드의 비대면 [대기] 경험을 분석하였고, 그 결과 [주문/결제] 이후 "번호를 지속해서 확인해야 함에도 그렇지 않은 경우"가 발생하고 있음을 발견했다. 이를 개선하기 위해 마이크로 인터랙션을 통한 시선 이동 유도에 대한 실험을 진행하였고, 이를 바탕으로 맥도날드 키오스크와 번호 전광판의 마이크로 인터랙션 디자인을 제안하였다.
Jang, Ji Eun,Cheong, June-Won,Kim, Soo-Jeong,Cho, Hyunsoo,Suh, Cheolwon,Lee, Hyewon,Eom, Hyeon-Seok,Yhim, Ho-Young,Lee, Won-Sik,Min, Chang-Ki,Lee, Jae Hoon,Park, Joon Seong,Kim, Jin Seok Informa UK (Informa Healthcare) 2016 Leukemia & lymphoma Vol.57 No.6
<P>To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. In comparison with patients who achieved at least a very good partial response (VGPR) to induction therapy and received granulocyte-colony stimulating factor (G-CSF) alone and patients who did not achieve a VGPR and received cyclophosphamide (CY)+G-CSF, treatment-related toxicity was greater and neutrophil engraftment was slower in the CY than the G-CSF group. The rate of requisite mobilization (2.0x10(6)/kg) was similar in both groups. Overall and progression-free survival was not different between patients in the G-CSF group and patients who achieved at least VGPR and received CY+G-CSF. In conclusion, response-adapted selection of a mobilization regimen is appropriate. G-CSF alone should be the preferred treatment for patients who achieved at least a VGPR to induction therapy.</P>
Jang, Min-Young,Lee, Moo-Sik,Hong, Jee-Young,Kim, Hyunsoo,Kim, Kwang-Hwan,Bae, Seok-Hwan Korean Society for Health Education and Promotion 2016 보건교육건강증진학회지 Vol.33 No.3
Objectives: Physical activity is well known as one of the most effective health behaviors for maintaining and promoting health. The purpose of this study was to investigate the regional variation, compositional and contextual factors on physical activities in Korea. Methods: This study analyzed data of 6,353 adults in 4th-1, 2 Korea National Health and Nutrition Examination Survey (KNHANES). Independent variables were compositional factors that included general characteristics, health behaviors, health status, and contextual factors that included physical environment, political environment, and social safety net. Dependent variables were vigorous physical activity, moderate physical activity, and walking activity. Multilevel analysis were used to determine a variation of physical activity between levels of compositional factors and contextual factors. Results: Physical activities of the Korean people were affected by the regional variables. Financial independence and population density were related with moderate physical activity significantly. Population density, school sport or rally spaces, cultural facilities, and social safety concerns were related with walking activity significantly. These variables impacted on physical activities along with variables at the individual level. Variance Partition Coefficient were 9.94% at moderate physical activity and 2.91% at walking activities, respectively. Conclusions: The results suggest that the regional variables should be considered when planning public intervention to promoting physical activities in Korean adults.
Electrical Characteristics of Metal Contacts to Laser-Irradiated N-Polar n-Type GaN
Hyunsoo Kim,Jae-Hyun Ryou,Dupuis, R.D.,Taesung Jang,Yongjo Park,Sung-Nam Lee,Tae-Yeon Seong IEEE 2009 IEEE electron device letters Vol.30 No.4
<P>Electrical characteristics of metal contacts to a laser-irradiated thin-film N-polar n-type GaN surface are investigated. It is shown that the laser irradiation of the N-polar n-GaN results in a significant increase (as high as 3.0 times 10<SUP>20</SUP> cm<SUP>-3</SUP>) in the electron concentration and a decrease in the Schottky barrier height by 0.05 eV (0.28 eV), as estimated using Pt-based Schottky diodes (X-ray photoemission spectroscopy). Ti/Al contacts to the laser-irradiated N-polar sample exhibit an excellent Ohmic behavior with thermal stability up to 600degC, indicating that the laser irradiation treatment can be a very promising technology in practical applications.</P>