[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study

Jeon, So Yeon,Seo, Seongho,Lee, Jae Sung,Choi, Soo-Hee,Lee, Do-Hyeong,Jung, Ye-Ha,Song, Man-Kyu,Lee, Kyung-Jun,Kim, Yong Chul,Kwon, Hyun Woo,Im, Hyung-Jun,Lee, Dong Soo,Cheon, Gi Jeong,Kang, Do-Hyung Williams & Wilkins Co 2017 Medicine Vol.96 No.1

ABSTRACT: Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case–control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [C]-(R)-PK11195. [C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30–55 years) and 12 control subjects (30–52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis. The DVR of [C]-(R)-PK11195 in the caudate nucleus (t(21) = −3.209, P = 0.004), putamen (t(21) = −2.492, P = 0.022), nucleus accumbens (t(21) = −2.218, P = 0.040), and thalamus (t(21) = −2.395, P = 0.026) were significantly higher in CRPS patients than in healthy controls. Those of globus pallidus (t(21) = −2.045, P = 0.054) tended to be higher in CRPS patients than in healthy controls. In patients with CRPS, there was a positive correlation between the DVR of [C]-(R)-PK11195 in the caudate nucleus and the pain score, the visual analog scale (r = 0.661, P = 0.026, R = 0.408) and affective subscales of McGill Pain Questionnaire (r = 0.604, P = 0.049, R = 0.364). We demonstrated that neuroinflammation of CRPS patients in basal ganglia. Our results suggest that microglial pathology can be an important pathophysiology of CRPS. Association between the level of caudate nucleus and pain severity indicated that neuroinflammation in this region might play a key role. These results may be essential for developing effective medical treatments.

마찰에너지율을 이용한 타이어 제동거리 예측

전도형(Do-Hyung Jeon),최주형(Joo-Hyung Choi),조진래(Jin-Rae Cho),김기전(Gi-Jeon Kim),우종식(Jong-Shik Woo) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.4

This study is concerned with the braking distance estimation using frictional energy rate. First, steady state rolling analysis is performed, and using this result, the braking distance is estimated. Dynamic rolling analysis during entire braking time period is impratical, so that this study divides the vehicle velocity by 10㎞/h to reduce the analysis time. The multiplication of the slip rate and the shear stress provides the frictional energy rate. Using frictional energy rate, total braking distance is estimated. In addition. ABS(Anti-lock Brake System) is considered, and two type of slip ratios are compared. One is 15% slip ratio for the ABS condition. and the other is 100% slip ratio which leads to the almost same braking distance as the elementary kinematic theory. A slip ratio is controlled by angular velocity in ABAQUS/Explicit. A 15% slip ratio gives the real vehicle's braking distance when the frictional energy occurred at disk pad is included. Disk pad's frictional energy rate is calculated by the theoretical approach,

유한요소법을 이용한 구동상태에 따른 타이어의 특성 분석

전도형(Do-Hyung Jeon),최주형(Joo-Hyung Choi),조진래(Jin-Rae Cho),김기운(Kee-Woon Kim) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.11

This paper discusses the measurement of tire driving performance for 2 types of tire model. Tire is almost composed of rubber, and this is related with the bearing capacity of tire due to the external force. In this study, an explicit time integration method has been used to simulate steady state rolling along a straight path and over a cleat. And analysis for tire dynamic response rolling over a cleat is importnat to study automobile NVH properties. Besides, the evaluation of contact shear force is perfomed for steady state rolling and braking state. The results show that there are noticeable differences between 205/60R15 and 225/60R15 tire model.

Cu2+ ion reduction in wastewater over RDF-derived char

Hyung Won Lee,Rae-su Park,Sung Hoon Park,Sang-Chul Jung,Jong-Ki Jeon,Sang Chai Kim,Jin Do Chung,Won Geun Choi,Young-Kwon Park 한국탄소학회 2016 Carbon Letters Vol.18 No.-

Refuse-derived fuel (RDF) produced using municipal solid waste was pyrolyzed to produce RDF char. For the first time, the RDF char was used to remove aqueous copper, a representative heavy metal water pollutant. Activation of the RDF char using steam and KOH treatments was performed to change the specific surface area, pore volume, and the metal cation quantity of the char. N2 sorption, Inductively Coupled Plasma-Atomic Emission Spectrometer (ICP-AES), and Fourier transform infrared spectroscopy were used to characterize the char. The optimum pH for copper removal was shown to be 5.5, and the steam-treated char displayed the best copper removal capability. Ion exchange between copper ions and alkali/alkaline metal cations was the most important mechanism of copper removal by RDF char, followed by adsorption on functional groups existing on the char surface. The copper adsorption behavior was represented well by a pseudo-second-order kinetics model and the Langmuir isotherm. The maximum copper removal capacity was determined to be 38.17 mg/g, which is larger than those of other low-cost char adsorbents reported previously.

A preliminary study on surgical navigation for epiduroscopic laser neural decompression

Jeon, Sangseo,Lee, Gun Woo,Jeon, Young Dae,Park, Il-Hyung,Hong, Jaesung,Kim, Jae-Do Professional Engineering Publishing Ltd. 2015 Proceedings of the Institution of Mechanical Engin Vol. No.

<P>Epiduroscopic laser neural decompression is an emerging therapeutic modality to treat lumbar spine pathologies including chronic low back pain, spinal stenosis, and disk herniation via catheter insertion followed by laser ablation of the lesion. Despite the efficacy of epiduroscopic laser neural decompression, excessive radiation doses due to fluoroscopy during epiduroscopic laser neural decompression have limited its widespread application. To address the issue, we propose a surgical navigation system to assist in epiduroscopic laser neural decompression procedures using radiation-free image guidance. An electromagnetic tracking system was used as the basic modality to track the internal location of the surgical instrument with respect to the patient body. Patient-to-image registration was carried out using the point-based registration method to determine the transformation between the coordinate system of the patient and that of the medical images. We applied the proposed system in epiduroscopic laser neural decompression procedures to assess its effectiveness, and the outcomes confirmed its clinical feasibility. To the best of our knowledge, this is a report on the first surgical navigation applied for epiduroscopic laser neural decompression procedure.</P>

Enhanced electrocatalytic performance of Pt nanoparticles on triazine-functionalized graphene nanoplatelets for both oxygen and iodine reduction reactions

Jeon, In-Yup,Kweon, Do Hyung,Kim, Seong-Wook,Shin, Sun-Hee,Im, Yoon Kwang,Yu, Soo-Young,Ju, Myung Jong,Baek, Jong-Beom The Royal Society of Chemistry 2017 Journal of Materials Chemistry A Vol.5 No.41

<▼1><P>Triazine-functionalized graphene nanoplatelets were synthesized for use as platinum nanoparticle supports. The Pt/TfGnP catalyst exhibited high electrocatalytic activity with superb stability for both the ORR and IRR.</P></▼1><▼2><P>Platinum (Pt) nanoparticles were stably anchored on triazine-functionalized graphene nanoplatelets (TfGnPs), which were prepared by a two-step reaction starting from carboxylic acid- (CGnPs), acyl chloride- (AcGnPs) and amide-functionalized graphene nanoplatelets (AfGnPs). The resulting Pt nanoparticles on TfGnPs (Pt/TfGnPs) exhibited outstanding electrocatalytic activity with significantly enhanced stability compared with commercial Pt-based catalysts for the oxygen reduction reaction (ORR) in fuel cells (FCs) and the iodine reduction reaction (IRR) in dye-sensitized solar cells (DSSCs). For the ORR in FCs, the onset and half-wave potentials of Pt/TfGnPs under acidic conditions displayed greater positive shifts to 0.58 and 0.53 V, respectively, than those of the commercial Pt/C catalyst (0.57 and 0.52 V). For the IRR in DSSCs, Pt/TfGnPs displayed a reduced charge transfer resistance (<I>R</I>ct) of 0.13 Ω cm<SUP>2</SUP> at the CE/electrolyte interface. This value was much lower than the Pt CE of 0.52 Ω cm<SUP>2</SUP>. More importantly, Pt/TfGnPs exhibited profoundly improved electrochemical stability in both the ORR and IRR compared to the Pt-based catalysts. The combination of extraordinarily high electrocatalytic activity with stability could be attributed to the high specific surface area (963.0 m<SUP>2</SUP> g<SUP>−1</SUP>) and the triazine units of the TfGnPs, respectively, which provided more active sites and stably anchored the Pt nanoparticles.</P></▼2>

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-035 : Mycobacterial Diseases ; Treatment Outcomes in 70 Patients Undergoing Adjuvant Resectional Surgery for Nontuberculous Mycobacterial Lung Disease

( Hyung Koo Kang ),( Hye Yun Park ),( Do Hun Kim ),( Byeong Ho Jeong ),( Kyeong Man Jeon ),( Hong Kwan Kim ),( Yong Soo Choi ),( Jhin Gook Kim ),( Won Jung Koh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Outcomes of antibiotic treatment for lung disease caused by nontuberculous mycobacteria (NTM) are unsatisfactory.Methods: We conducted a retrospective review of 70 patients who underwent pulmonary resection for NTM lung disease from March 2007 to February 2013. All patients received recommended antibiotic treatment before and after the surgery. Results: A total of 70 patients underwent 74 operations. The median age of the patients was 50 years (IQR, 43-58 years). Of the 70 patients, 45 (64%) had Mycobacterium avium complex infection (24 M. intracellulare and 21 M. avium), 23 (33%) had M. abscessus complex infection (15 M. abscessus and 8 M. massiliense), and two (3%) had mixed infection. Thirty-eight (54%) patients had the nodular bronchiectatic form and 28 (40%) had the fi brocavitary form of NTM lung disease. The indications for surgery were a poor response to drug therapy (n = 52), remnant cavitary lesions and severe bronchiectasis (n = 14), and hemoptysis (n = 4). Preoperative sputum acid-fast bacilli staining results were positive in 44 (63%) patients, and sputum culture was positive in 54 (76%). The surgery included lobectomy or lobectomy plus segmentectomy (n = 50, 68%), segmentectomy (n = 11, 15%), pneumonectomy or completion pneumonectomy (n = 8, 11%), bilobectomy or bilobectomy plus segmentectomy (n = 4, 5%), and one wedge resection. Postoperative complications occurred in 15 (21%) patients, including postoperative death (n = 1) and bronchopleural fi stula (n = 5). A negative sputum culture was achieved and maintained in 57 (81%) patients. Conclusions: Although adjuvant pulmonary resection is associated with a relatively high complication rate, this procedure could provide a high level of treatment success for selected patients with NTM lung disease, such as those with a poor response to antibiotic treatment alone

Enhancement of Protein Productivity of Recombinant Hepatitis A Virus VP1 in Stably Transfected $Drosophila$ $melanogaster$ S2 Cells

Jeon, Hwang-Bo,Park, Jong-Hwa,Lee, Hyun-Ho,Kim, Do-Hyung,Lee, Hee-Young,Shon, Dong-Hwa,Kim, Won-Yong,Chung, In-Sik The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.1

The effect of DMSO and sodium butyrate on the production of recombinant hepatitis A virus (HAV) capsid protein VP1 was evaluated and optimized in the culture of stably transfected $Drosophila$ $melanogaster$ S2 cells using culture plates and spinner flasks. The effect of DMSO and sodium butyrate was also evaluated to improve the recombinant VP1 production in stably transfected $Drosophila$ S2 cells. A production level of 0.88 mg of recombinant VP1/liter was obtained in the culture-plate culture of stably transfected S2 cells at 6 days after induction with 0.5 mM $CuSO_4$. The supplements of 2% DMSO and 10 mM sodium butyrate at 4 days post-inoculation increased recombinant VP1 accumulation by 141 and 104%, respectively, resulting in 2.17 and 1.7 mg/liter of recombinant VP1 production. In spinner flasks, recombinant VP1 production reached maximum level at 9 days after induction with 0.5 mM $CuSO_4$, with approximately 4.96 mg/liter of recombinant VP1 production level. When 2% DMSO or 10 mM sodium butyrate was added at 5 days post-inoculation, the recombinant VP1 production was increased to 8.35 and 5.85 mg/liter, respectively. However, the synergistic effects of DMSO and sodium butyrate were not observed. These results indicate that DMSO and/or sodium butyrate can be successfully used to improve the recombinant HAV VP1 production in culture plates and spinner flasks.

Lepidopterous Insects Composition in Jindo Island, Korea in Summer

Hyung-Keun Lee,Do-Sung Kim,Yong Lak Jeon,Hee-Nam Yoon,Jung-Hyo Lee,Seong-Joon Park 한국동물분류학회 2016 Animal Systematics, Evolution and Diversity Vol.- No.s9

We surveyed the biodiversity of lepidopterous insects in Jindo Island using UV bucket trap in July 2016 to determine the relationship between surrounding environment and ecosystem in order to contribute to biodiversity conservation and management of coastal islands in Korea. Based on our survey results, a total of 262 lepidopterous insect species in 16 families were collected from Jindo Island. Members belonging to families Noctuidae and Geometridae made up approximately half of the total species (86 species [32.82%] in Noctuidae and 44 species [16.79] in Geometridae). There were 29 species (11.07%) belonging to Crambidae and 28 species (10.69%) belonging to Pyralidae. As a result of all collections based on previous literature and this study, a total of 730 species belonging to 34 families were collected from Jindo Island, including 33 protected species, 242 species (33.15%) belonging to Noctuidae (the most abundant), 124 species (16.99%) belonging to Geometridae, 79 species (10.82%) belonging to Crambidae, and 65 species (8.90%) belonging to Pyralidae. The most frequently collected species was Lamoria glaucalis in this syudy. Our results on the diversity of lepidopterous insects will provide basic information for future investigation on diverse changes in the ecosystem of Jindo Island, Korea.

Lepidopterous Insects Composition in Jindo Island, Korea in Summer

Hyung-Keun Lee,Do-Sung Kim,Yong Lak Jeon,Hee-Nam Yoon,Jung-Hyo Lee,Seong-Joon Park 한국동물분류학회 2016 Korean Journal of Systematic Zoology Special Issue Vol.- No.9

We surveyed the biodiversity of lepidopterous insects in Jindo Island using UV bucket trap in July 2016 to determine the relationship between surrounding environment and ecosystem in order to contribute to biodiversity conservation and management of coastal islands in Korea. Based on our survey results, a total of 262 lepidopterous insect species in 16 families were collected from Jindo Island. Members belonging to families Noctuidae and Geometridae made up approximately half of the total species (86 species [32.82%] in Noctuidae and 44 species [16.79] in Geometridae). There were 29 species (11.07%) belonging to Crambidae and 28 species (10.69%) belonging to Pyralidae. As a result of all collections based on previous literature and this study, a total of 730 species belonging to 34 families were collected from Jindo Island, including 33 protected species, 242 species (33.15%) belonging to Noctuidae (the most abundant), 124 species (16.99%) belonging to Geometridae, 79 species (10.82%) belonging to Crambidae, and 65 species (8.90%) belonging to Pyralidae. The most frequently collected species was Lamoria glaucalis in this syudy. Our results on the diversity of lepidopterous insects will provide basic information for future investigation on diverse changes in the ecosystem of Jindo Island, Korea.