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Roh Hyun Woong,Kim Na-Rae,이동기,Cheong Jae-Youn,Seo Sang Won,Choi Seong Hye,Kim Eun-Joo,Cho Soo Hyun,Kim Byeong C.,Kim Seong Yoon,Kim Eun Young,Chang Jaerak,Lee Sang Yoon,Yoon Dukyong,Choi Jin Wook,An Y 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.2
Objective We aimed to present the study design and baseline cross-sectional participant characteristics of biobank innovations for chronic cerebrovascular disease with Alzheimer’s disease study (BICWALZS) participants.Methods A total of 1,013 participants were enrolled in BICWALZS from October 2016 to December 2020. All participants underwent clinical assessments, basic blood tests, and standardized neuropsychological tests (n=1,013). We performed brain magnetic resonance imaging (MRI, n=817), brain amyloid positron emission tomography (PET, n=713), single nucleotide polymorphism microarray chip (K-Chip, n=949), locomotor activity assessment (actigraphy, n=200), and patient-derived dermal fibroblast sampling (n=175) on a subset of participants.Results The mean age was 72.8 years, and 658 (65.0%) were females. Based on clinical assessments, total of 168, 534, 211, 80, and 20 had subjective cognitive decline, mild cognitive impairment (MCI), Alzheimer’s dementia, vascular dementia, and other types of dementia or not otherwise specified, respectively. Based on neuroimaging biomarkers and cognition, 199, 159, 78, and 204 were cognitively normal (CN), Alzheimer’s disease (AD)-related cognitive impairment, vascular cognitive impairment, and not otherwise specified due to mixed pathology (NOS). Each group exhibited many differences in various clinical, neuropsychological, and neuroimaging results at baseline. Baseline characteristics of BICWALZS participants in the MCI, AD, and vascular dementia groups were generally acceptable and consistent with 26 worldwide dementia cohorts and another independent AD cohort in Korea.Conclusion The BICWALZS is a prospective and longitudinal study assessing various clinical and biomarker characteristics in older adults with cognitive complaints. Details of the recruitment process, methodology, and baseline assessment results are described in this paper.
Roh, Hyun Woong,Hong, Chang Hyung,Lee, SooJin,Lee, Yunhwan,Lee, Kang Soo,Chang, Ki Jung,Oh, Byoung Hoon,Choi, Seong Hye,Kim, Seong Yoon,Back, Joung Hwan,Chung, Young Ki,Lim, Ki Young,Noh, Jai Sung,Son Wolters Kluwer Health 2015 Medicine Vol.94 No.45
<P><B>Abstract</B></P><P>To determine the association between frontal lobe function and risk of hip fracture in patients with Alzheimer disease (AD).</P><P>Retrospective cohort study using multicenter hospital-based dementia registry and national health insurance claim data was done. Participants who had available data of neuropsychological test, national health insurance claim, and other covariates were included. A total of 1660 patients with AD were included based on Stroop Test results. A total of 1563 patients with AD were included based on the Controlled Oral Word Association Test (COWAT) results. Hip fracture was measured by validated identification criteria using national health insurance claim data. Frontal lobe function was measured by Stroop Test and COWAT at baseline.</P><P>After adjusting for potential covariates, including cognitive function in other domains (language, verbal and nonverbal memory, and attention), the Cox proportional hazard regression analysis revealed that risk of a hip fracture was decreased with a hazard ratio (HR) of 0.98 per one point of increase in the Stroop Test (adjusted HR = 0.98, 95% confidence interval [CI]: 0.97–1.00) and 0.93 per one point increase in COWAT (adjusted HR = 0.93, 95% CI: 0.88–0.99).</P><P>The risk of hip fracture in AD patients was associated with baseline frontal lobe function. The result of this research presents evidence of association between frontal lobe function and risk of hip fracture in patients with AD.</P>
국한성 두경부 대세포성(Diffuse Large Cell) 림프종의 적정 방사선 조사선량
금웅섭(Woong Sub Koom),서창옥(Chang Ok Suh),김용배(Yong Bae Kim),심수정(Su Jung Shim),표홍렬(Hongryull Pyo),노재경(Jae Kyung Roh),정현철(Hyun Cheol Chung),김귀언(Gwi Eon Kim) 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.4
목적 : 두경부에 국한된 1기, 2기 대세포성(diffuse large cell) 비호치킨 림프종의 항암화학방사선 병용요법 시 방사선 조사영역 내의 재발을 예방하기 위한 적정 방사선 조사선량을 알아보고자 하였다. 대상 및 방법 : 1985년 5월부터 1998년 12월까지 국한성 두경부 대세포성 림프종으로 항암화학요법 후 방사선치료를 받은 53명을 대상으로 하였다. 나이는 13세부터 69세까지였으며 중앙값은 49세였다. 남녀 비는 1.65대 1이었고 1기, 2기 환자가 각각 27명, 26명이었다. 종양 크기별로 5cm 미만이 30명, 5cm 이상이 23명이었다. 원발부위는 경부림프절 22명, 편도 20명, 비인두 4명, 설기저부 3명, 부비동 2명, 후두 1명, 연구개 1명이었다. 항암화학요법은 1명을 제외하고 3회 이상 시행되었으며 방사선치료는 48명이 원발부위와 경부임파선을, 5명이 원발부위만 치료하였다. 생존율, 무병생존율, 조사영역 내 무재발생존율과 방사선 조사선량에 따른 방사선 조사영역 내에서의 재발빈도를 조사하였다. 결과 : 항암화학요법 후 44명(83%)이 완전관해 되었고 연이은 방사선치료 후 53명 모두 완전관해 되었다. 12명(23%)이 재발하였고 그중 2명은 방사선 조사영역 내 재발이었고 방사선 조사영역 바깥 재발은 11명으로 복강 및 ㄱ 반 내 림프절이 가장 많았다. 방사선 조사선량 별 조사영역 내 재발은 30~35 Gy에서 7명 중 1명, 35~40 Gy에서 16명중 1명이었고 40 Gy 이상에서는 재발이 없었다. 방사선 조사영역 내 재발은 30~35 Gy에서 7명 중 1명, 35~40 GY에서 16명중 1명이었고 40 Gy 이상에서는 재발이 없었다. 방사선 조사영역 내 재발에 유의한 예후인자는 없었으나 5cm 이상인 종양에서 재발하였고 5cm 미만인 종양은 30 Gy에서도 재발하지 않았다. 10년 방사선 조사영역내 무재발 생존율, 무병생존율, 전체생존율은 각각 96%, 76%, 75%였다. 결론 : 국한성 두경부 대세포성 림프종서 함암화학방사선 병용요법 시 종양의 크기가 5cm 미만은 경우에는 30 Gy의 방사선 조사선량으로도 국소제어를 할 수 있다. 따라서 방사선치료에 따르는 구강건조증을 최소화시킬 수 있을 것이다. 5cm 이상의 종양에서는 30 Gy 이상의 방사선 조사 선량이 필요하리라 생각된다. Purpose : To determine the optimal radiation dose in a localized non-Hodgkin's lymphoma of the head and neck in the treatment setting for combined chemoradiotherapy. Materials and Methods : Fifty-three patients with stage Ⅰ and Ⅱ diffuse large cell non-Hodgkin's lym-phoma of the head and neck, who were treated with combined chemoradiotherapy between 1985 and 1998 were retrospectively reviewed. The median age was 49 years, and the male-to-female ratio was ap-proximately 1.6. Twenty-seven patients had stage I disease and 26 had stage Ⅱ. Twenty-three patients had bulky tumors (≥5 cm) and 30 had non-bulky tumors (<5 cm). The primary tumors arose mainly from an extranodal organ (70%), most cases involving Waldeyer's ring (90%). All patients except one were initially treated with 3~6 cycles of chemotherapy, which was followed by radiotherapy. Radiation was de-livered either to the primary tumor area alone (9%) or to the primary tumor area plus the bilateral neck nodes (91%) with a minimum does of 30 Gy (range 30~60 Gy). The failure patterns according to the radiation field were analyzed, and the relationship between the dose and the in-field recurrence was evaluated. Results : The 10-year overall survival and the 10-year disease free survival rates were similar at 75% and 76%, respectively. A complete response (CR) after chemotherapy was achieved in 44 patients (83%). Subsequent radiotherapy showed a CR in all patients. Twelve patients (23%) had a relapse of the lym-phoma after the initial treatment. Two of these patients had a recurrence inside the radiation field. No clear dose response relationship was observed and no significant prognostic factors for the in-field recur-rence <5 cm in diameter, there were no in field recurrences after a radiation dose 30 Gy. The 2 in-field recurrences encoutered occurred in patients with a tumor ≥5 cm. conclusion : A dose of 30 Gy is sufficient for local control in patients with a non-bulky (<5 cm), lo-calized, diffuse large cell non-Hodgkin's lymphoma when combined with chemotherapy. An additional boost dose in the primary site is recommended for patients with bulky tumors (≥5 cm).
USN 센서 노드 용 Wake-up 모듈 설계 및 구현
김현웅(Hyun-Woong Kim),김도원(Do-Won Kim),박희정(Hee-Jeong Park),노형환(Hyoung-Hwan Roh),김형석(Hyeong-Seok Kim),오하령(Ha-Ryoung Oh),성영락(Yeong Rak Seong),박준석(Jun-Seok Park) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
다양한 환경에서 무선 센서노드 시스템이 적용됨에 따라 센세노드와 싱크노드 시스템의 통신 방식이 중요해 지고 있다. 이에 본 논문은 통신 방식 중 진폭 변조 방식을 사용한 통신방식에서의 복조회로를 이용하여 복조된 신호에 따라 센서 노드를 구동 시킬 수 있는 wake-up 모듈을 설계하고 제안한다. 보다 효율적인 복조를 위해 동적기준전압 방식의 복조회로를 구현함으로써 저전압 입력 시에도 복조가 가능하게 하여 센서노드의 인식거리를 확대하였다. 또한 제안된 회로를 시스템에 직접 적용하여 실제 진폭변조 신호의 복조를 이용하여 wake-up 모듈을 적용 시켰을 시 센서 노드가 동작성을 확인함으로써 센서노드 시스템에 적용 가능함을 보였다.
노웅래(Woong-Rae Roh),조현철(Hyun-Chul Cho),안재명(Jae-Myung Ahn),최형돈(Hyung-Don Choi) 한국항공우주학회 2004 韓國航空宇宙學會誌 Vol.32 No.3
KSR-Ⅲ 로켓은 액체추진 엔진을 사용한 과학로켓이며, 추력 비행중 피치 및 요 자세제어를 위해 추력벡터제어 방식을 사용하고, 롤 자세를 제어하기 위해 냉가스 추력기를 사용하였다. 본 논문은 KSR-Ⅲ 로켓의 3축 자세제어를 위해 설계된 자세제어기의 구조와 이득 스케쥴링, 자세 안정성 분석결과에 대해 소개한다. 설계된 자세제어기는 국산화 개발된 관성 항법시스템의 비행소프트웨어로 구현되었는데 비행시험에서 완벽히 작동하였다. 비행에서 측정된 데이터는 시뮬레이션 결과와 거의 일치되었다. The KSR-Ⅲ rocket is a liquid propellant sounding rocket and thrust vector control actuators and cold gas thrusters are used to control pitch and yaw, roll attitude respectively during thrusting phase. In this paper, the structure of designed attitude controller and gain scheduling, results of stability analysis for KSR-Ⅲ rocket are presented. The attitude controller is implemented with flight software in the domestically developed INS and successfully performed its function in the flight test. The flight data are coincident with simulation results.