http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구
김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.
Yang, Ying‐,Gui,Koh, Young Wha,Sari, Ita Novita,Jun, Nayoung,Lee, Sanghyun,Phi, Lan Thi Hanh,Kim, Kwang Seock,Wijaya, Yoseph Toni,Lee, Sang Hun,Baek, Moo‐,Jun,Jeong, Dongjun,Kwon, Hyog You Alan R. Liss, Inc 2019 International journal of cancer Vol.144 No.8
<P>Emerging data indicate that interferon‐induced transmembrane protein 1 (IFITM1) plays an important role in many cancers. However, it remains unclear whether IFITM1 is functionally indispensable in nonsmall cell lung cancer (NSCLC). Here, using NSCLC cell lines and patient‐derived samples, we show that IFITM1 is essentially required for the progression of NSCLC <I>in vitro</I> and <I>in vivo</I>. Specifically, IFITM1 depletion resulted in a significant reduction in sphere formation, migration, and invasion of NSCLC cells <I>in vitro</I>; these events were inversely correlated with the ectopic expression of IFITM1. In addition, tumor development was significantly impaired in the absence of IFITM1 <I>in vivo</I>. Mechanistically, epidermal growth factor receptor/sex‐determining region Y‐box 2 (EGFR/SOX2) signaling axis was compromised in the absence of IFITM1, and the ectopic expression of SOX2 partially rescued the defects caused by IFITM1 depletion. More importantly, using 226 patient‐derived samples, we demonstrate that a high level of IFITM1 expression is associated with a poor overall survival (OS) rate in adenocarcinoma but not in squamous cell carcinoma. Collectively, these data suggest that IFITM1 is a poor prognostic marker of adenocarcinoma and an attractive target to develop novel therapeutics for NSCLC.</P>
온도 및 생장조절제가 국내 육성 사과 품종의 화분발아율 및 화분관 신장에 미치는 영향
권헌중(Hun-Joong, Kweon),박무용(Moo-Yong Park),송양익(Yang-Yik, Song),손광민(Kwang-Min Son),사공동훈(Dong-Hoon Sagong) (사)한국생물환경조절학회 2016 생물환경조절학회지 Vol.25 No.3
본 시험은 만개기 기온(15~40oC) 및 생장조절제(GA4+7+BA와 prohexadione-calcium) 살포가 국내 주요 사과품종(‘후지’, ‘쓰가루’)과 국내에서 육성한 품종들(‘추광’, ‘감홍’, ‘홍안’, ‘홍금’, ‘홍로’, ‘홍소’, ‘화홍’, ‘섬머드림’, ‘선홍’)의 화분 발아율 및 화분관 신장에 미치는 영향을 조사하고자 실시하였다. 15℃부터 25℃까지 온도가 올라갈수록 화분 발아율과 화분관 신장 길이는 증가되었으나, 30℃ 이상의 고온은 화분 발아율과 화분관 신장 길이를 억제시켰다. 30oC 이상의 고온에서 화분 발아율과 화분관 신장 길이가 가장 높았던 국내 육성 사과품종은 ‘선홍’이었다. GA4+7+BA 살포는 무처리구에 비해 화분 발아율 및 화분관 신장 길이를 증진시켰으나, 이러한 효과는 40℃에서 발생하지 않았다. prohexadione-calcium 살포는 화분 발아율과 화분관 신장 길이에 영향을 주지 않았다. 결론적으로, 사과나무 만개기 기온이 30~35℃ 정도로 높아지면, 인공수분 후 GA4+7+BA를 살포하는 것이 착과 증진에 좋을 것으로 판단되었다. This study was carried out to investigate the effect of temperature (15~40℃) and the spraying plant growth regulators (GA4+7+BA and prohexadione-calcium) during full blooming on pollen germination and pollen tube growth of the commercial apple cultivars (‘Fuji’ and ‘Tsugaru’) and apple cultivars bred in Korea (‘Chukwang’, ‘Gamhong’, ‘Hongan’, ‘Honggeum’, ‘Hongro’, ‘Hwahong’, ‘Hongso’, ‘Summer dream’ and ‘Sunhong’). Pollen germination and pollen tube growth were increased with increasing temperature from 15 to 25℃, but high temperature over 30℃ inhibit those. The apple cultivar bred in Korea that shows the highest value on pollen germination and pollen tube growth at over 30℃ was ‘Sunhong’. The spraying GA4+7+BA increased pollen germination and pollen tube growth than control, but that effect was not show at 40℃. The spraying prohexadione-calcium was not affect to pollen germination and pollen tube growth. In conclusion, if the air temperature during full bloom of apple tree rises about 30~35℃, the spraying GA4+7+BA after artificial pollination will be good to increasing fruit set.