하악골 결손부의 골형성에 미치는 Bioplant HTRⓡ의 영향

최도현,유선열,김옥준,허원실 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

The present study was performed to investigate the effect of HTR□ (Hard Tissue Replacement) on osteogenesis in the mandibular bone defects. Eight adult male white rabbits weighing 2.5 to 3.0kg were used. Four bone defects (8mm in diameter and 4mm in depth) were made at the both mandibular body. In the control group, the right mesial bone defect was filled with blood clot and spontaneously healed, In the DFDB group, the right distal bone defect was filled with xenogenic demineralized freeze-dried bone. In the HTR□ group, the left mesial bone defect was filled with HTR□. In the HTR□-membrane group, the left dis- tal bone defect was filled with HTR□ and covered with BioMesh membrane. The rabbits were sacrified at 2,4,6 and 9 weeks after the operation and microscopic examination was performed. Results obtained were as follows: In the control and DFDB groups, inflammatory cells and the fibrous connective tissue existed and the bone growth was slower than HTR□ group by 6 week, and there was intervention of the soft tissue at 9 week. In the HTR□ group, bone trabeculi extended between the HTR□ particles without intervention of inflammatory cells and the connective tissue at 4 and 6 weeks. In addition, extensive osseous ingrowth into the HTR□ particles was observed at 9 week. Bone formation was more active in the HTR□ group than the control and DFDB groups. There was not obvious difference in the bone healing rate between the HTR□ and the HTR□-membrane group. These results suggest that the HTR□ promotes osteogenesis in the bone defects and the HTR□ group has no difference in comparison with the HTR□-BioMesh□ membrane group in bone healing.

악관절 습관성 탈구에 대한 외과적 악관절경술의 임상 성적

최도현,허원실,정 훈 대한 두개하악 장애학회 1999 대한두개하악장애학회지 Vol.11 No.2

In treating habitual dislocation of TMJ, generally there are two ways; conservative and open surgery, Conservative treatment has a high recurrence rate and open surgery involves surgical invasion. Consequently, many results of conservative and open surgery were unsatisfactory. Arthroscopic surgery for habitual dislocation of the TMJ solved the problems above. It is useful due to little recurrence, reducing surgical invasion and simple technique. Arthroscopic surgery was performed for on 18 cases out of 19 joints of patients who visited out hospital from May, 1989 to June, 1995. 18 cases of 19 joints after initial surgery showed good results and only one joint had recurrence. Even that one case improved after secondary arthroscopic surgery. Therefore, surgical arthroscopy is thought to be the best method for habitual dislocation of TMJ.

Influence of Sodium Hyaluronate Concentration on Corneal Aberrations in Soft Contact Lens Wearers

Jong Soo Lee,Jong Moon Park,Hyun Kyung Cho,Su Jin Kim,Hyoun Do Huh2,Young Min Park 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.2

Purpose: This study aimed to evaluate the influence of varying concentrations of sodium hyaluronate (SH) eye drops on corneal aberrations in normal individuals wearing silicone hydrogel contact lenses. Methods: Normal individuals wearing silicone hydrogel contact lenses were enrolled in this study. Subjects were classified into two groups depending on the concentration of the preservative-free SH used (group 1, 0.1% SH; group 2, 0.3% SH). All subjects were asked to blink five times after instillation of the SH eye drop and before the Galilei measurements. Corneal aberrations were measured over the contact lenses before and after SH eye drop instillation. Visual acuity (VA) over the contact lenses was also measured both before instillation of the SH eye drop and after the subjects completed the five blinks. Results: There was no change in VA after SH instillation in group 1; however, group 2’s VA significantly deteriorated after SH instillation. Changes in VA after SH instillation compared to baseline were significantly higher in group 2 than in group 1. Similarly, the increase in corneal aberrations after SH instillation was significant in group 2 but not significant in group 1. Among the significantly increased corneal aberration parameters, defocus was the main type in group 2. Changes in corneal aberrations after SH instillation compared to baseline were significantly higher in group 2 than in group 1. Conclusions: A 0.3%-concentration of SH increases corneal aberration and decreases VA in soft contact lens wearers. Defocus is the main type of aberration that increased in the 0.3% SH instillation group.

Control of Oscillation Pattern in the Malonic acid-Bromate-Ruthenium-Hydroquinone Reaction by the Illumination of Visible Light

Huh, Do-Sung,Choe, Young-Min,Park, Do-Young,Park, Sung-Hyun,Zhao, Yan-Suhang,Choe, Sang-Joon Korean Chemical Society 2005 Bulletin of the Korean Chemical Society Vol.26 No.2

Control of Oscillation Pattern in the Malonic acid-Bromate-Ruthenium-Hydroquinone Reaction by the Illumination of Visible Light

Do Sung Huh*,Young Min Choe,Do Young Park,Sung Hyun Park,Yan Suhang Zhao,Sang Joon Choe 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.2

3D dosimetry by compass program with array detector for volumetric modulated arc therapy

Hyun Do Huh,Sang Hyoun Choi,Sang Hyoun Choi,Hun Jeong Kim,Seong Hoon Kim,Young Hoon Ji,Kum Bae Kim,Dong oh Shin,Suk Lee,Jang Bo Shim,Sam Ju Cho,Sang Hoon Lee,Kwang Hwan Cho,Chul Kee Min 대한방사선방어학회 2011 대한방사선방어학회 학술발표회 논문요약집 Vol.2011 No.11

History of Radiation Therapy Technology

Huh, Hyun Do,Kim, Seonghoon Korean Society of Medical Physics 2020 의학물리 Vol.31 No.3

Here we review the evolutionary history of radiation therapy technology through the festschrift of articles in celebration of the 30th anniversary of Korean Society of Medical Physics (KSMP). Radiation therapy technology used in clinical practice has evolved over a long period of time. Various areas of science, such as medical physics, mechanical engineering, and computer engineering, have contributed to the continual development of new devices and techniques. The scope of this review was restricted to two areas; i.e., output energy production and functional development, because it is not possible to include all development processes of this technology due to space limitations. The former includes the technological transition process from the initial technique applied to the first model to the latest technique currently used in a variety of machines. The latter has had a direct effect on treatment outcomes and safety, which changed the paradigm of radiation therapy, leading to new guidelines on dose prescriptions, innovation of dose verification tools, new measurement methods and calculation systems for radiation doses, changes in the criteria for errors, and medical law changes in all countries. Various complex developments are covered in this review. To the best of our knowledge, there have been few reviews on this topic and we consider it very meaningful to provide a review in the festschrift in celebration of the 30th anniversary of the KSMP.

The Characteristics of $V_H$ Gene Family Expression in Early B Cells

JEONG Hyun Do,HUH Min-Do The Korean Society of Fisheries and Aquatic Scienc 1995 한국수산과학회지 Vol.28 No.1

B 세포가 다양화되어 가는 기작을 규명한다는 것은 면역 반응의 조절이 생체 내에서 어떻게 이루어지고 있는 가를 이해하는데 가장 기본이 되는 것이다. 본 연구는 기 확립한 in situ hybridization 기법을 이용하여 항체의 항원 결합 부위 유전자가 B 세포의 발달 과정 중 어떻게 조절이 되고 있으며 이것은 B 세포의 다양화라는 측면과 어떻게 연관이 되어 있는 지를 분석하였다. Gestation 시기가 16일, 18일, 19일, 20일 되었을 때간에 있는 B 세포는 $V_H7183$와 $V_HQ52$두개의 $V_H$ 유전자군을 가장 많이 이용하고 있었으며 이러한 경향은 gestation 기간 전체를 통하여 변화 없이 일정하게 나타났다. 간에 있는 fetal B 세포를 differentiation 단계별로 구분하기 위하여 표면 항체를 갖고 있는 집단과, 갖고 있지 않은 두 집단으로 나눈 후 각 집단이 발현하는 $V_H$ 유전자를 분석하였을 때 뚜렷한 차이를 나타냄이 없이 양쪽 집단 모두 fetus의 특징적 $V_H$ 이용양식을 보여주었다. 또 다른 조혈 기능 임파 기관인 fetal spleen에 있는 B 세포 또한 fetal liver의 B 세포와 동일한 양상의 $V_H$ 유전자 이용 양식을 보여 주어 각 임파 기관별 B 세포의 다양성 차이를 발견 할 수 없었다. 이와 같이 adult의 B 세포에 대비하여 독특한 $V_H$ 유전자 이용 양상을 보이는 fetal B 세포의 전구 세포를 4주 이상 미리 형성시킨 adult 골수 세포와 직접 접촉시키면서 발달, 성숙시킨 후 다시 나타난 B 세포를 분석하여도 여전히 fetal B 세포로서의 $V_H$ 유전자 이용 양상을 보이는 것은 fetal B세포의 전구 세포가 갖고 있는 유전적 잠재력에 의한 것이지 환경이나 B 세포의 differentiation 단계 또는 B 세포가 머무르고 있는 특수 임파 장기의 생리적 환경 등에 좌우되는 것이 아니라는 것이 확인되었다. Defining the mechanisms of B cell diversification which establish the immune repertoire is fundamental to understand how the immune response is regulated. In this report, B cell differentiation and diversification focused on the regulation of immunoglobulin $V_H$ gene expression during ontogeny were analyzed by in situ hybridization technique. Fetal liver B cells in .different gestational days from 16d to 20d showed the predominant expression of $V_H7183$ and $V_HQ52$ without transition of repertoire during the observed gestation days. The two subsets of fetal liver B cells separated according to different differentiation stages based on the presence of tell surface immunoglobulin also did not indicate apparent difference in expressed $V_H$ gene family profiles. B cells in fetal spleen as an another hematopoietic lymphoid tissue in fetus also expressed similar $V_H$ gene repertoire to that in fetal liver B cells. This distinct pattern of $V_H$ gene expression in fetal B cells from that of adult B cells were not changed even after four weeks contact with adult bone marrow microenvironment supplied by the established adult bone marrow stromal cell layers. Thus, the restricted $V_H$ gene repertoire of B cells in fetus which is distinct from that in adult appears to be associated more with the genetic potential of fetal B cell progenitors and less with environmental influences or differentiation stages or compartmentalization.

근접방사선치료용 다목적 팬톰을 이용한 직장 내 선량분석

허현도(Hyun Do Huh),김성훈(Seong Hoon Kim),조삼주(Sam Ju Cho),이석(Suk Lee),신동오(Dong Oh Shin),권수일(Soo il Kwon),김현정(Hun Jung Kim),김우철(Woo Chul Kim),노준규(John J K Loh) 대한방사선종양학회 2005 Radiation Oncology Journal Vol.23 No.4

목 적: 근접방사선 치료시 직장내 선량측정은 치료간(inter-fraction) 직장의 형태가 변화하므로 측정의 재현성을 이 룰 수 없다. 본 연구에서는 근접방사선치료용 다목적 팬톰(Multi Purpose Brachytherapy Phantom, MPBP)을 제작하 여 치료 시와 동일한 조건을 재현하였고 이때 측정한 선량 값을 직장의 부작용을 줄이기 위해 선량최적화에 적용 하고자 하였다. 대상 및 방법: 자궁경부암 근접방사선 치료 시 탄뎀(tandem)과 난형체(ovoid)를 사용한 환자 4명을 대상으로 다이오드 검출기를 이용하여 직장표시 기준점 R1에서 선량측정을 시행하였다. 환자 당 5회씩 총 20회 직장선량을 측정하였다. 그리고 반복 측정 시 다이오드 검출기의 설정 변화(set up variation)를 분석하였다. 그리고 자체 제작된 근접방사선치료용 다목적 팬톰에서 MFA (Multi Function Applicator)를 이용하여 치료 시와 동일한 조건을 재현한 후열형광선량계(TLD)를 이용하여 직장 표시 기준점 좌표 위치에서 선량을 측정하였다. 결 과: 직장 내 다이오드 검출기의 측정 결과 설정 변화는 환자 1의 경우에 Y방향에서 최고 11.25±0.95 mm보였고, 환자 2와 3은 Z 방향에서 각각 9.90±2.40 mm와 20.85±4.50 mm를 나타냈다. 그리고 환자 4는 Z 방향에서 19.15±3.33 mm의 변화를 나타내었다. 또한 다이오드 검출기 위치에 따른 평균선량 값은 122.82±7.96 cGy∼323.78 ± 11.16 cGy로 나타났다. MPBP에서 TLD의 측정 결과는 직장 표시 기준점(R1)에서 환자1과 4는 상대오차가 각각 최고 8.6%와 7.7%를 보였고, 환자2와 3은 각각 1.7%와 1.2%의 오차를 보였다. 그리고 R과 R2에서 측정한 선량 값들은 환자 2의 R 지점을 제외하고 계산값과 비교하여 1.7∼8.6% 높은 값을 나타냈다. 그리고 반복측정으로 인한 위치변화와 그에 따른 선량 값의 변화는 분석하지 않았다. 계산 값과 측정값의 상대오차가 미국의학물리학회 보고서에서 권고한 15% 내에서 잘 일치하는 것으로 분석되었다. 결 론: 자체 제작된 근접치료용 다목적 팬톰(MPBP)은 치료 시와 동일한 조건에서 선량측정의 재현성을 이룰 수 있었고, 직장의 기준점에서 선량을 정확히 분석할 수 있었다. 또한 팬톰에서 측정한 데이터를 이용하여 직장의 부작용을 줄이기 위해 치료 전 선량 최적화를 이루는데 충분한 자료로 활용할 수 있다고 판단되었다. Purpose: In this work we designed and made MPBP (Multi Purpose Brachytherapy Phantom). The MPBP enables one to reproduce the same patient set-up in MPBP as the treatment of the patient and we tried to get an exact analysis of rectal doses in the phantom without need of in-vivo dosimetry. Materials and Methods: Dose measurements were tried at a point of rectum 1, the reference point of rectum, with a diode detector for 4 patients treated with tandem and ovoid for a brachytherapy of a cervix cancer. Total 20 times of rectal dose measurements were made with 5 times a patient. The set-up variation of the diode detector was analyzed. The same patient set-ups were reproduced in self-made MPBP and then rectal doses were measured with TLD. Results: The measurement results of the diode detector showed that the set-up variation of the diode detector was the maximum 11.25±0.95 mm in the y-direction for Patient 1 and the maximum 9.90±2.40 mm, 20.85± 4.50 mm, and 19.15±3.33 mm in the z-direction for Patient 2, 3, and 4, respectively. In analyzing the degree of variation in 3 directions the more variation was showed in the z-direction than x- and y-direction except Patient 1. The results of TLD measurements in MPBP showed the relative maximum error of 8.6% and 7.7% at a point of rectum 1 for Patient 1 and 4, respectively and 1.7% and 1.2% for Patient 2 and 3, respectively. The doses measured at R1 and R2 were higher than those calculated except R point of Patient 2. This can be thought to related to the algorithm of dose calculation, whcih corrects for air and water but is guessed not to consider the correction for the scattered rays, but by considering the self-error (±5%) TLD has the relative error of values measured and calculated was analyzed to be in a good agreement within 15%. Conclusion: The reproducibility of dose measurements under the same condition as the treatment could be achieved owing to the self-made MPMP and the dose at the point of interest could be analyzed accurately. If a treatment is performed after achieving dose optimization using the data obtained in the phantom, dose will be able to be minimized to important organs.

생물학 ; 나일 틸라피아에 대한 질병예방제 및 면역보조제로서의 PS - K 효과 분석

박경현(Kyun Hyun Park),하재이(Jai Yi Ha),허민도(Min Do Huh),허성회(Sung Hoi Huh),정현도(Hyun Do Jeong) 부경대학교 기초과학연구소 1998 부경대 기초과학연구논문집 Vol.1 No.-