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정훈진(Hoon-Jin Jeong),강내운(Nae-Woon Kang),이승재(Seung-Jae Lee) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
In tissue engineering, bioreactor systems have been designed to provide a variety of stimulation witch reproduced environment in the human body. It is important that the design of bioreactor is well induced high cellular activity, initial cell attachment, cell proliferation and differentiation. Our research team has developed a bioreactor system that imitate the various stimulus environment in the knee joint. A developed bioreactor designed to be able to culture cells was separated by three zones according to stimulation at the bending motion. The scaffolds fabricated by SLUP(Salt leaching using powder) method were inserted into the each zone to cell culture. Consequently, we developed bioreactor with optimal environment for cell culture, such as HEPA filter, supply of CO2 gas and temperature controller.
3차원 형상정보에 따른 생체모방형 무릎관절 구동의 변화
정훈진(Hoon-Jin Jeong),이승재(Seung-Jae Lee) 한국산업정보학회 2015 한국산업정보학회논문지 Vol.20 No.3
본 논문에서는 인체의 CT/MRI에서 단층 촬영된 무릎관절을 영상처리 과정을 거쳐 3차원 관절 모델을 제작하였다. 실제 무릎관절의 형상을 추출할 때 설정 조건에 따라 3차원 형상정보가 달라질 수 있다. 이러한 미세한 3차원 형상정보의 차이에 따른 무릎관절의 구동특성을 분석하기 위해 2가지의 관절 모델을 3차원 프린터를 이용하여 제작하였다. 제작된 관절모델을 이용하여 관절구동 시압축력 실험을 수행하였고 형상의 차이에 따라 결과값의 차이가 발생하였다. 따라서 생체모방형 바이오리액터를 개발할 경우에는 형상정보의 차이에 대한 연구가 선행되어야 할 것으로 사료된다. We fabricated a 3D knee joint model through the imaging processing. The 3D shape information is different depends on specific conditions when the shape of real knee joint is extracted from CT/MRI sliced images. The two types of joint models were fabricated by using 3D printer in order to analysis of joint movement by slight difference of 3D shape information. The compressive force experiments were performed by using knee joint model. As the results, the compressive forces were changed with respect to the difference of geometry. Consequently, feasibility test should be performed before developing biomimetic bioreactor.
정훈진(Hoon Jin Jeong),지민희(Min-Hee Jee),김소연(So-Youn Kim),이승재(Seung-Jae Lee) 한국기계가공학회 2014 한국기계가공학회지 Vol.13 No.2
Recent experimental observations support the hypothesis that mechanical stimuli play a role in regulating the specialized molecular expression of articular cartilage in vitro and in vivo. Other studies have demonstrated that the continuous passive motion(CPM)bioreactor for whole joints can provide a platform for possible future in vitro studies and applications, including possible interactions of bio-mechanical and biochemical signals. In this study, we have developed acustom-made bioreactor capable of bending and stretching with circular type motion, and a biomimetic knee joint model, using a 3D printer. This system could be used to investigate the effects of rehabilitative joint motion of dynamic culture.
김소연(So-Youn Kim),지민희(Min-Hee Jee),정훈진(Hoon Jin Jeong),이인환(In-Hwan Lee),이승재(Seung-Jae Lee) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Recent experimental researches support the hypothesis that mechanical stimuli play a role in regulating specialized molecules expression in articular cartilage in vitro and in vivo. Therefore we are studying bioreactor to provide a stimulus of mimicked real knee environment. Our bioreactor system consists of a joint motion stimulation device and culture chamber. We fabricated a stimulation system similar to movement of the CPM device for human joint motion. This system is composed of a linear stage, ball-spline and links. Also we fabricated a culture system for media circulation and mimicked knee environment. However, previous culture system has some problems that media leakage and interference of joint model. In this study, we improved a new-chamber system for non-interference of joint model and medium sealing. Then, this system could be used to investigate the effect of dynamic culture.