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Excellent Strengthening of Low-Carbon Steel by Severe Free-End Torsion
Shijun Tan,Bo Song,Hongbing Chen,Xiaodong Tan,Risheng Qiu,Tingting Liu,Ning Guo,Shengfeng Guo 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8
In this work, the effects of free-end torsion on microstructure and tensile property of low-carbon steel were investigated indetail. Low-carbon steels exhibited exceptionally high yield strength through severe torsion deformation. Such high hardeningeffect was mainly attributed to the severe lattice distortion, high density of dislocations and the change in grain shape. Moreover, a gradient deformation structure can be introduced by torsion deformation. The gradient-structure can generate ahigh hetero-deformation induced strengthening, which can increase the strain hardening capacity and remain high plasticity/toughness. Therefore, with increasing torsion angle from 700 to 2800 deg., the uniform elongation and the peak strength werelargely enhanced. After twisting 2800 deg., yield strength and peak strength can achieve 524 MPa and 675 MPa, respectively,and good tensile elongations (εf = 9.6%, εu = 7.4%) are remained.
Kaiyun Qin,Fenghua Zhang,Hongxia Wang,Na Wang,Hongbing Qiu,Xinzhuan Jia,Shan Gong,Zhengmao Zhang 생화학분자생물학회 2023 BMB Reports Vol.56 No.3
Ovarian cancer (OC) is the most common gynecological malignancyworldwide, and chemoresistance occurs in most patients,resulting in treatment failure. A better understanding of themolecular processes underlying drug resistance is crucial fordevelopment of efficient therapies to improve OC patient outcomes. Circular RNAs (circRNAs) and ferroptosis play crucialroles in tumorigenesis and resistance to chemotherapy. However,little is known about the role(s) of circRNAs in regulatingferroptosis in OC. To gain insights into cisplatin resistance inOC, we studied the ferroptosis-associated circRNA circSnx12. We evaluated circSnx12 expression in OC cell lines and tissuesthat were susceptible or resistant to cisplatin using quantitativereal-time PCR. We also conducted in vitro and in vivoassays examining the function and mechanism of lnc-LBCSs. Knockdown of circSnx12 rendered cisplatin-resistant OC cellsmore sensitive to cisplatin in vitro and in vivo by activatingferroptosis, which was at least partially abolished by downregulationof miR-194-5p. Molecular mechanics studies indicatethat circSnx12 can be a molecular sponge of miR-194-5p, whichtargets SLC7A11. According to our findings, circSnx12 amelioratescisplatin resistance by blocking ferroptosis via a miR-194-5p/SLC7A11 pathway. CircARNT2 may thus serve as an effectivetherapeutic target for overcoming cisplatin resistance in OC.