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- 저자 : Hongbao Zhao (검색결과 3 건)
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Tao Wang,Hongbao Zhao,Yihong Liu,Shaoqiang Liu,Rui Liu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.8
During the mining process of Hami open-pit coal mine, a large number of cracks appeared on the ground surface near the top of the end slope, which affected the stability of the slope and the subsequent safe mining of resources. By analyzing the deformation of rock stratum, the position of weak interlayer in the slope was determined. Considering the rock mass with weak interlayer as a complete mechanical system, the mechanical model of the rock mass system with weak interlayer was established, and the evaluation index of rock failure degree before slope instability was proposed. The failure mode of slope with weak interlayer is as follows: sliding failure-cutting layer failure-tension failure. The safety factor of slope decreases first and then increases with the increase of the depth of the weak interlayer, and gradually decreases with the increase of the inclination of the weak interlayer. The pressing foot of slope can be used in landslide control of slope with weak interlayers, and the optimal pressing foot solution to ensure the safe mining of final slope coal resources was determined to be a pressing foot height of 35 m and pressing foot width of 20 m.
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Du Jiawei,Zhao Hui,Song Guibing,Pang Yuan,Jiang Lei,Zan Linsen,Wang Hongbao 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.2
Objective: Muscle acetylcholine receptors have five alpha subunits (α, β, δ, ε, or γ), and cholinergic receptor nicotinic gamma subunit (CHRNG) is the γ subunit. It may also play an essential role in biological processes, including cell differentiation, growth, and survival, while the role of CHRNG has not been studied in the literature. Therefore, the purpose of this study is to clarify the effect of CHRNG on the proliferation and differentiation of bovine preadipocytes. Methods: We constructed a CHRNG overexpression adenovirus vector and successfully overexpressed it on bovine preadipocytes. The effects of CHRNG on bovine preadipocyte proliferation were detected by Edu assay, cell counting Kit-8 (CCK-8), real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), Western blot and other techniques. We also performed oil red O, RT-qPCR, Western blot to explore its effect on the differentiation of preadipocytes. Results: The results of Edu proliferation experiments showed that the number of EDUpositive cells in the overexpression group was significantly less. CCK-8 experiments found that the optical density values of the cells in the overexpression group were lower than those of the control group, the mRNA levels of proliferating cell nuclear antigen (PCNA), cyclin A2 (CCNA2), cyclin B1 (CCNB1), cyclin D2 (CCND2) decreased significantly after CHRNG gene overexpression, the mRNA levels of cyclin dependent kinase inhibitor 1A (CDKN1A) increased significantly, and the protein levels of PCNA, CCNB1, CCND2 decreased significantly. Overexpression of CHRNG inhibited the differentiation of bovine preadipocytes. The results of oil red O and triglyceride determination showed that the size and speed of lipid droplets accumulation in the overexpression group were significantly lower. The mRNA and protein levels of peroxisome proliferator activated receptor gamma (PPARγ), CCAAT enhancer binding protein alpha (CEBPα), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN) decreased significantly. Conclusion: Overexpression of CHRNG in bovine preadipocytes inhibits the proliferation and differentiation of bovine preadipocytes.
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Jianhang Chen,Kangming Tao,Banquan Zeng,Lei Liu,Hongbao Zhao,Junwen Zhang,Danqi Li 한국콘크리트학회 2023 International Journal of Concrete Structures and M Vol.17 No.1
A better understanding of the tensile performance and tensile failure mechanism of cement paste is significant in preventing rock reinforcement failure. Therefore, this paper aims to reveal the tensile performance and failure mechanism of a modified Portland cement: Stratabinder HS cement. To achieve this objective, the split tensile test was conducted on specimens followed by simulating the failure mechanism numerically. The results indicated that the water–cement rate significantly influenced the tensile performance of the cement paste. When the water–cement rate increased from 0.35 to 0.42, the tensile strength declined from 1.9 MPa to 1.5 MPa. It was also observed that vertical tensile failure constantly occurred regardless of the water–cement rate. During the testing process, tensile cracks and shear cracks occurred. The increasing rate in the number of specimen cracks was dependent on the tensile stress state. Before the tensile stress reached the peak, the crack quantity increased slightly. After the peak, the crack quantity increased dramatically. During the vertical loading process, horizontal tensile stress occurred in the specimen. This horizontal tensile stress zone showed a diamond shape. The higher the tensile stress is, the larger the area of the horizontal tensile stress zone. When the tensile strength was reached, horizontal tensile stress mainly concentrated at the vertical centre of the specimen. This finally led to tensile failure of the specimen. This paper indicated that the water–cement rate was the key factor in evaluating the tensile strength of the Stratabinder HS cement.
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