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RISS 인기검색어
- 검색키워드
- 저자 : Hollinger,Jeffrey O. (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
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Lee, Gang,Hollinger, Richard C. The Korean Association for Survey Research 2010 조사연구 Vol.11 No.2
The purpose of this study is to determine the unidimensionality of Grasmick's operationalization of Gottfredson and Hirschi's criminality inducing the concept of low self-control. By applying confirmatory factor analysis procedures that incorporate advances in the application, the proposed six factor model and two alternative models were examined suggesting that Grasmick's low self-control scale actually contains 6 distinguishable factors, not a single factor. The factors identified to be consistent with the six-factor model were impulsivity, simple tasks, risk seeking, physical activities, self-centered, and temper.
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김진구,Jeffrey O. Hollinger 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.2
The purpose of the study was to determine the effects of dual administration of recombinant human platelet derived growth factor-BB (rhPDGF-BB) and recombinant human bone morphogenetic protein-2 (rhBMP-2) on proliferation and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Either rhPDGF-BB or rhBMP-2 or a combination of the two factors was administered into hMSCs. Proliferation and osteogenic differentiation were determined by measuring DNA concentration, alkaline phosphatase (ALP) activity and mineralization (von Kossa staining) at days 7, 14 and 21. The data revealed that the administration of rhPDGF-BB (days 1-7) followed by rhBMP-2 (days 7-21) resulted in a significant increase of ALP activity and extracellular mineral deposition of hMSCs as compared to that of either factor alone or concurrent administration of the two factors. In addition, rhP-DGF-BB treatment at days 1-7 significantly increased proliferation of hMSCs without decreasing osteogenic differ-entiation. The results underscored the importance of a coordinated, temporal sequence of rhPDGF-BB and rhBMP-2 administration to modulate hMSC osteogenic differentiation. The study was a compelling advancement towards producing a therapy exploiting temporal, dual administration of physiological doses of rhPDGF-BB and rhBMP-2.
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( Gang Lee ),( Richard C. Hollinger ) 한국조사연구학회 2010 조사연구 Vol.11 No.2
The purpose of this study is to determine the unidimensionality of Grasmick`s operationalization of Gottfredson and Hirschi`s criminality inducing the concept of low self-control. By applying confirmatory factor analysis procedures that incorporate advances in the application, the proposed six factor model and two alternative models were examined suggesting that Grasmick`s low self-control scale actually contains 6 distinguishable factors, not a single factor. The factors identified to be consistent with the six-factor model were impulsivity, simple tasks, risk seeking, physical activities, self-centered, and temper.
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Charged Beads as Cutaneous Wound Healing Factors in Rhesus Non-Human Primates
Cho, Seong-Pil,Hollinger, J. G. 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-
The goal for this project is to produce a convenient and pecuniarily advantageous therapeutic to enhance cutaneous wound healing. Towards that goal, we have developed a candidate material: charged Sephadex beads(CSB).
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토끼 두개골 결손창에 대한 골형성단백질을 함유한 골왁스 처치 효과에 관한 연구
최재구,하승일,김준범,Hollinger,Jeffrey O. 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.7
Bone is a storehouse of biologic factors enabling it to regenerative without scar formation. Recombinant technology has made many of these factors available in significant quality for therapeutic applications. However, a delivery system of recombinant bone regenerating factors is needed. Biodegradable, biocompatable polymers have made it possible for delivering bone regenerative factors, such as bone morphogenetic protein(BMP). The overall goal of this study was to assess an experimental biodegradable polymer with wax-like handling properties that was combined with recombinant simian transforming growth factor beta(rs TGF-β). The purpose of this study was to validate biodegradability, biocompatability, hemostasis and bone promotion within standard-sized defects. The experimental design included 24 skeletally mature New-Zealand white rabbit divided evenly between two time periods (6 and 12 weeks) and the experimental wound model was two standard-sized circular defects 8 mm in diameter on each side of rabbit calvaria. At necropsy, a rectangular-shape segment of the calvaria was removed that included the parietal bones and defect sites. The segment was radiographed and x-ray films were assessed for radiopacity by computer assisted imaging analysis technique(i.e, radiomorphometry). Following radiography, bone formation within the defects was quantified by a computer imaging technique(hismtorphometry). Radiopacity associated with the experimental bone wax polymers was significantly greater than that of the untreated controls. Quantitative histomorphometry revealed the amount of new bone within the untreated controls was significantly greater than the experimentally treated sites. As a result, bone-wax did not satisfy the condition of ideal carrier of BMP but had some advantage in clinical use. The follow-up study must be produced for improvement of the substitution of bone with BMP in carrier.
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Cho, Hong Y.,Srinivasan, Abiraman,Hong, Joanna,Hsu, Eric,Liu, Shiguang,Shrivats, Arun,Kwak, Dan,Bohaty, Andrew K.,Paik, Hyun-jong,Hollinger, Jeffrey O.,Matyjaszewski, Krzysztof American Chemical Society 2011 Biomacromolecules Vol.12 No.10
<P>Star polymers with poly(ethylene glycol) (PEG) arms and a degradable cationic core were synthesized by the atom transfer radical copolymerization (ATRP) of poly(ethylene glycol) methyl ether methacrylate macromonomer (PEGMA), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and a disulfide dimethacrylate (cross-linker, SS) via an “<I>arm-first</I>” approach. The star polymers had a diameter ∼15 nm and were degraded under redox conditions by glutathione treatment into individual polymeric chains due to cleavage of the disulfide cross-linker, as confirmed by dynamic light scattering. The star polymers were cultured with mouse calvarial preosteoblast-like cells, embryonic day 1, subclone 4 (MC3T3-E1.4) to determine biocompatibility. Data suggest star polymers were biocompatible, with ≥80% cell viability after 48 h of incubation even at high concentration (800 μg/mL). Zeta potential values varied with N/P ratio confirming complexation with siRNA. Successful cellular uptake of the star polymers in MC3T3-E1.4 cells was observed by confocal microscopy and flow cytometry after 24 h of incubation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-10/bm2006455/production/images/medium/bm-2011-006455_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bm2006455'>ACS Electronic Supporting Info</A></P>
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