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Ghang, Ho-Young,Han, Young-Joo,Jeong, Sang-Jin,Bhak, Jong,Lee, Sung-Hoon,Kim, Tae-Hyung,Kim, Chul-Hong,Kim, Sang-Soo,Al-Mulla, Fahd,Youn, Chan-Hyun,Yoo, Hyang-Sook,The HUGO Pan-Asian SNP Consortium, T Korea Genome Organization 2011 Genomics & informatics Vol.9 No.4
In planning a model-based phylogenic study for highly related ethnic data, the SNP marker number is an important factor to determine for relationship inferences. Genotype frequency data, utilizing a sub sampling method, from 63 Pan Asian ethnic groups was used for determining the minimum SNP number required to establish such relationships. Bootstrap random sub-samplings were done from 5.6K PASNPi SNP data. DA distance was calculated and neighbour-joining trees were drawn with every re-sampling data set. Consensus trees were made with the same 100 sub-samples and bootstrap proportions were calculated. The tree consistency to the one obtained from the whole marker set, improved with increasing marker numbers. The bootstrap proportions became reliable when more than 7,000 SNPs were used at a time. Within highly related ethnic groups, the minimum SNPs number for a robust neighbor-joining tree inference was about 7,000 for a 95% bootstrap support.
Anti-wrinkle Compounds Isolated from the Seeds of Arctium lappa L.
Ju-Young Hwang(황주영),Tae-Soon Park(박태순),Dong-Hee Kim(김동희),Eun-Young Hwang(황은영),Jung-Noh Lee(이정노),Ji young Lee(이지영),Ghang-Tai Lee(이강태),Kunkook Lee(이건국),Jun-Ho Son(손준호) 한국생명과학회 2012 생명과학회지 Vol.22 No.8
본 연구에서는 우방자를 70% 에탄올로 추출하여 얻어진 추출물을 n-hexane, methylene chloride, ethyl acetate로 순차용매 분획하였다. 각 분획물에 대해 activity-guided isolation을 수행하여 활성물질의 분리 정제를 실시하였다. 활성을 나타내는 물질은 silica gel chromatography (230 mesh), sephadex LH 20, recrystallization method를 이용하여 분리하였다. 각 화합물의 화학구조는 NMR 스펙트럼 데이터 해석하였고 arctiin, arctigenin, diarctigenin, matairesinol 으로 동정하였다. 이들을 human dermal fibroblast HS68 세포에 처리하여 얻어진 상등액은 ELISA kit를 활용하여 procollagen type Ⅰ생합성과 MMP-1 저해활성을 측정하였다. 측정결과 procollagen type Ⅰ생합성과 MMP-1 저해활성 결과 모두 arctiin이 가장 우수한 결과를 보였다. 이와 같은 결과를 통해 우방자에서 분리한 리그난 화합물들을 이용하여 주름개선 소재로 개발할 수 있을 것으로 사료 된다. This study was carried out to discover the skin wrinkle reducing components in the seeds of Arctium lappa. The isolation of a methylene chloride-soluble fraction of 70% ethanol extract from the seeds of Arctium lappa using a procollagen type-1 synthesis and MMP-1 activity resulted in the isolation and identification of four lignin compounds: arctiin, arctigenin, matairesinol, and diarctigenin. All structures were confirmed via NMR and MS spectroscopic data. To determine cell viability and procollagen type-1 synthesis, human dermal fibroblasts were treated with 10-100 μM. As a result, none of the four compounds showed cytotoxicity up to 50 μM. We also investigated their procollagen type-1 synthesis and MMP-1 inhibition activity and found that arctiin had the highest activity in terms of both procollagen synthesis and MMP-1 inhibition among all four compounds. Putting all the data together, we suggest that arctiin be used in cosmetics as an anti-wrinkle material.
Behavioral alterations by Importin-11 mutation in mice
Ju-Young Lee,Eun-Kyoung Kim,Yong-Sub Byun,Hae-Rim Kim,Yu-Rim Kim,Min-Young Lee,Sang-Mi Cho,Ho-Young Ghang,Ki-Hoon Lee,Ok-Seong Moon,Young-Won Seo,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Bae-Hwan Ki 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.2
Rhbdf2 null mutation alleviate the severity of collagen-induced arthritis in mice
Min-Young Lee,Yong-Sub Byun,Eun-Kyoung Kim,Hae-Rim Kim,Yu-Rim Kim,Ju-Young Lee,Sang-Mi Cho,Ho-Young Ghang,Ki-Hoon Lee,Ok-Seung Moon,Young-Won Seo,Won-Kee Yoon,Young-Suk Won,Hyoung-Chin Kim,Kyung-Chul 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.2
Basic phenotyping platform for genetically engineered mouse at KRIBB
Hae Rim Kim,Eun Kyoung Kim,Yong Sub Byun,Kang Ju Seong,Ju Young Lee,Yu Rim Kim,Min Young Lee,Sang Mi Cho,Taek Chang Lee,Hae Jin Lee,Young Ho Kho,Ok Seong Moon,Young Won Seo,Ki Hoon Lee,Hoyoung Ghang,W 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8
The deficiency of Fryl gene induces neonatal lethality
Yong Sub Byun,Eun Kyoung Kim,Hae Rim Kim,Ju Sung Kang,Yu Rim Kim,Ju Young Lee,Min Young Lee,Sang Mi Cho,Ho Young Ghang,Ki Hoon Lee,Won Kee Yoon,Young Suk Won,Hyoung Chin Kim,Kyung Chul Choi,Ki Hoan Na 한국실험동물학회 2015 한국실험동물학회 학술발표대회 논문집 Vol.2015 No.8