http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A new 9,11-secisterik with a 1,4-quinone from a Korean marine sponge Ircinia sp.
( Inho Yang ),( Hyukjae Choi ),( Sang Jip Nam ),( Heonjoong Kang ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
An intensive investigation of chemical com-ponents for Ircinia sp. Ied to the isolation of a new 9,11-secosterol. The chemical structure of this compound was elucidated based on the interpretation of NMP and MS spectrosopic data. The isolated compound exhibited an-tibacterial activities against Staphylococcus epidermidis and Bacillus subtilis with MIC values of 6.3 and 25 μg Mi<sub>-1</sub>, respectively.
Antibacterial Butenolides from the Korean Tunicate <i>Pseudodistoma antinboja</i>
Wang, Weihong,Kim, Hiyoung,Nam, Sang-Jip,Rho, Boon Jo,Kang, Heonjoong American Chemical Society and American Society of 2012 Journal of natural products Vol.75 No.12
<P>Six new (<B>1</B>, <B>2</B>, and <B>5</B>–<B>8</B>) and three known (<B>3</B>, <B>4</B>, and <B>9</B>) butenolide metabolites were isolated from the tunicate <I>Pseudodistoma antinboja</I> by activity-guided fractionations. The structures were elucidated by combined NMR and MS spectroscopic methods. These compounds were evaluated for their antibacterial activity, and most of them exhibited moderate to significant activity that selectively targeted Gram-positive strains and did not exhibit cytotoxicity in the MTT assay at 100 μM. Cadiolides <B>5</B>–<B>9</B> in particular exhibited significant antibacterial activity that was comparable to or even better than those of marketed drugs such as vancomycin and linezolid against all of the drug-resistant strains tested.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2012/jnprdf.2012.75.issue-12/np300544a/production/images/medium/np-2012-00544a_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np300544a'>ACS Electronic Supporting Info</A></P>
LEE, KI-YOUNG,SHIN, DONG-SUN,YOON, JUNG-MIN,KANG, HEONJOONG,OH, KI-BONG 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.3
This paper describes the development of an enzymatic assay system for the identification of specific inhibitors of sortase, a transpeptidase that cleaves surface proteins of Gram-positive bacteria, from Staphylococcus aureus ATCC 6538p for antibacterial drug discovery. The coding region of the enzyme was amplified with the exception of the N-terminal membrane anchor sequence, cloned into a vector providing His-Patch-thioredoxin-tag at the N-terminus, expressed in Escherichia coli, and purified by metal chelate affinity chromatography. The enzyme activity was determined by quantifying increased fluorescence intensity upon cleavage of synthetic Dabcyl-QALPETGEE-Edans peptide. The results suggest that the developed in vitro assay system can be used in the search for sortase inhibitors in a short period of time.
Choi, Hyukjae,Oh, Sun Kwan,Yih, Wonho,Chin, Jungwook,Kang, Heonjoong,Rho, Jung-Rae The Pharmaceutical Society of Japan 2008 Chemical & pharmaceutical bulletin Vol.56 No.8
<P>Cyanopeptolin CB071 (1), a trypsin inhibitor, was isolated from the freshwater cyanobacterium <I>Aphanocapsa</I> sp. Its complete structure was determined by detailed NMR spectroscopy and MS analyses, along with chemical reactions. The compound showed inhibition of trypsin at a concentration of IC<SUB>50</SUB>=2.5 μ<SMALL>M</SMALL>.</P>