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Zhiling He,Guangyi Liu,Xianglin Yang,Wei Liu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
In this paper, a novel surfactant, N,N-diethyl-N0-cyclohexylthiourea (DECHTU) was synthesized and firstintroduced as a collector for chalcopyrite flotation. The micro-flotation results demonstratedchalcopyrite with adsorbed DECHTU exhibited good hydrophobicity and was effectively concentratedby nitrogen bubbles under pH 4–8. The adsorption of DECHTU onto chalcopyrite surfaces was fitted wellby the pseudo-second-order model and Langmuir isotherm, and was a spontaneously exothermicchemisorption process. The adsorption enthalpy change, entropy change and free energy change wereDH = 31.10 kJ mol 1, DS = 6.32 J mol 1 and DG (298 K) = 29.41 kJ mol 1, respectively. The activa-tion energy of the adsorption process was 17.39 kJ mol 1. The zeta potential results implied thatDECHTU adsorbed onto chalcopyrite surfaces as its anionic species with the release of H+ ion of NH–C(55S)–N group into aqueous solutions. The XPS spectra confirmed that there existed Cu(I)–DECHTUsurface complexes on chalcopyrite surface by bonding of copper atom with the sulfur atom of DECHTU,accompanying with the reduction of cupric to cuprous.
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Huang Yue,Li Zhiling,Lin En,He Pei,Ru Gaizhen 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In vitro fertilization (IVF) increases the risk of tumorigenesis in offspring. The increased oxidative damage during IVF may be involved in tumor formation. However, the molecular mechanisms underlying this phenomenon remain largely unclear. Using a well-established model of oxidatively damaged IVF mouse embryos, we applied the iTRAQ method to identify proteins differentially expressed between control and oxidatively damaged zygotes and explored the possible tumorigenic mechanisms, especially with regard to the effects of oxidative damage on ribosome biogenesis closely related to tumorigenesis. The iTRAQ results revealed that ribosomal proteins were upregulated by oxidative stress through the Nucleolin/β-Catenin/n-Myc pathway, which stimulated ribosomes to synthesize an abundance of repair proteins to correct the damaged DNA/chromosomes in IVF-derived embryos. However, the increased percentages of γH2AX-positive cells and apoptotic cells in the blastocyst suggested that DNA repair was insufficient, resulting in aberrant ribosome biogenesis. Overexpression of ribosomal proteins, particularly Rpl15, which gradually increased from the 1-cell to 8-cell stages, indicated persistent hyperactivation of ribosome biogenesis, which promoted tumorigenesis in offspring derived from oxidatively damaged IVF embryos by selectively enhancing the translation of β-Catenin and TGF-β1. The antioxidant epigallocatechin-3-gallate (EGCG) was added to the in vitro culture medium to protect embryos from oxidative damage, and the expression of ribosome-/tumor-related proteins returned to normal after EGCG treatment. This study suggests that regulation of ribosome biogenesis by EGCG may be a means of preventing tumor formation in human IVF-derived offspring, providing a scientific basis for optimizing in vitro culture conditions and improving human-assisted reproductive technology.
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