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Ji-Chang Zhou,Yu-Mei Zhu,Zheng Chen,Shan He,Shi-jie Zheng,Jun-luan Mo,Xiao-Li Liu,Chun-mei Gong,Bin Hou,Hui Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.5
Two single nucleotide polymorphisms (SNPs), rs2280788 (-28C[G) and rs2107538 (-403G[A), in the promoter region of chemokine (C–C motif) ligand 5 (CCL5) was reported to be involved in the immunoglobulin E (IgE) expression and IgE-mediated allergic reactions. This study was to investigate the characteristics of total serum IgE level, specific allergen sensitivities and the two SNPs in the allergic skin disease (ASD) patients. ASD patients visiting the dermatological outpatient department of a local hospital were included with certain criteria, and the fasting venous blood was sampled for analysis. Total serum IgE was assayed with an ELISA kit, and 14 kinds of allergen-specific IgE were tested with an allergen screening system. The polymerase chain reaction–restriction fragment length polymorphism method was used to analyze the two SNPs. Among the finally included 437 patients aged from 16 to 85 years, 68.2 % was positive for the total serum IgE, 49.2 % was positive for at least one of the assayed allergen-specific IgE, and 35.0 % was sensitive to house dust mite. In the SNPs analysis, the GG/(GA?AA) ratio and G/A ratio for the -403G[A locus in the male and/or female C45 years subgroup were significantly lower in the total serum IgE positive patients than in the negative patients (P\0.05). Weak linkage disequilibrium was found between -403A and -28C alleles in male subgroups adjusted by age. Conclusively, house dust mite was the most common allergen in ASD patients, and -403A allele of CCL5 promoter was a risk factor for IgE-mediated sensitization.
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Hua He,Diqiu Liu,Nannan Zhang,Wei Zheng,Qing Han,Bo Ji,Feng Ge,Chaoyin Chen 한국유전학회 2014 Genes & Genomics Vol.36 No.4
Pathogenesis-related (PR) proteins play keyroles in plant responses to pathogens and abiotic stresses. In this study, nine novel PR genes were isolated from Liliumregale Wilson, which is a wild lily species of Chinawith high-level resistance to the soilborne fungal pathogenFusarium oxysporum f. sp. lilii, and homology analysisclassified them into the PR10 family. These novel LrPR10swere clustered together with PR10s from monocotyledonsin a phylogenetic tree, moreover, phylogenetic analysisdivided the nine LrPR10s into two groups. The main-chainconformation and folding patterns of the LrPR10s werehighly conserved with other plant PR10s. The expressionpatterns of the nine LrPR10s in L. regale during normaldevelopment were examined by QRT-PCR, and the transcriptionlevels of the LrPR10s were relatively high inroots. Furthermore, QRT-PCR analysis indicated that theexpression levels of LrPR10-1, LrPR10-2, LrPR10-5,LrPR10-6, and LrPR10-7 in L. regale roots were up-regulatedby two or more stress-related signaling moleculesincluding salicylic acid, jasmonic acid, ethylene, and H2O2,while the other four LrPR10s were repressed by these foursignaling molecules. In addition, five members of theLrPR10 gene family including LrPR10-2, LrPR10-4,LrPR10-5, LrPR10-6, LrPR10-7, and LrPR10-9 werestrongly induced by F. oxysporum in resistant L. regalecompared with the susceptible Lilium Oriental hybrid‘Siberia’. The other four LrPR10s were down-regulated byF. oxysporum infection. In summary, our results indicatethat the members of PR10 gene family are involved inL. regale defense responses against F. oxysporum f. sp. lilii.
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Boundary layer effect of light transmission through ionic liquid under electric field
Zhou Ji,Zheng Yi,Dong Shikui,He Zhihong,Liu Bao,Zhang Yanhu 한국물리학회 2023 Current Applied Physics Vol.52 No.-
The field strength distribution in the ionic liquid boundary layer under the action of an external electric field is non-uniform. Whether its transmittance (absorption coefficient) spatially varies arouses our interest in exploring the underlying laws. In this paper, with the help of an infrared microscope, a special experimental device was designed and established. The transmittance in the ionic liquid (methyl propyl imidazole iodide, C3MImI) at different distances from the electrodes (cathode, anode) was measured under electric voltages from 0 V to 0.5 V. Results showed that transmittances of ionic liquid at the boundary layer present nonlinear change with the nonlinear electronic strength under the different applied voltage, and there is a critical threshold (0.2 V) distinguishes the sensitive and non-sensitive responses to the electric field. Our study provides a physical basis for microscale electro-optic regulation and is significant, especially for precise regulation of light field transmittance in micro-nano channels/structures.
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Zhao Fuping,Liu Rongmei,He Bei,Zheng Ke,Hu Xiaorui,Ji Jing,Hui Yan 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.9
More and more electric vehicles have been used in China, and many charging station has been built in China. Due to the reactive power loss caused by charging devices, the method to measure the power consumed by charging device is critical for power company. Based on impact loads generated by electric vehicles to the grid in fast charging mode, this paper studies the energy measurement method of electric vehicle charging mode. Since each phase current of charging post imbalance, to prevent the sum of each phase current vector of charging posts over the protection current threshold and the charging post breaker misusing in power circuit, preventing leakage circuit breaker current imbalance system is designed. Finally, this paper studies the power consumption detection methods of electric vehicle charging posts. By comparing the fast Fourier transform and wavelet analysis algorithms, an electric energy measurement device of electric vehicle charging machine based on FFT and wavelet analysis are proposed. Combined with fast data processing functions of DSP, the device can quickly and accurately measures electric vehicles charging amounts under different charging modes.
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Bing-Dong Sui,Ji Chen,Xin-Yi Zhang,Tao He,Pan Zhao,Chen-Xi Zheng,Meng Li,Cheng-Hu Hu,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the CD3+T-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.
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Nannan Zhang,Diqiu Liu,Wei Zheng,Hua He,Bo Ji,Qing Han,Feng Ge,Chaoyin Chen 한국유전학회 2014 Genes & Genomics Vol.36 No.6
The basic leucine zipper (bZIP) proteins areubiquitous in plants and play important roles in plantdefense responses. In this study, based on an expressedsequence tag from a suppression subtractive hybridizationcDNA library of Lilium regale Wilson during Fusariumoxysporum f. sp. lilii infection, a novel bZIP transcriptionfactor gene LrbZIP1 was isolated from L. regale root usingthe rapid amplification of cDNA ends method. The predictedprotein of LrbZIP1 with 142 amino acid residuescontains a basic domain signature and a leucine zippermotif. The quantitative reverse transcription-PCR (qRTPCR)analysis showed that the transcription level of Lrb-ZIP1 was higher in roots of L. regale than in young stemsand leaves. Moreover, the expression of LrbZIP1 was upregulatedin the incompatible interaction between L. regaleand F. oxysporum f. sp. lilii as well as after treatments withstress-related signaling molecules. To verify the function ofLrbZIP1, a constitutive expression vector of LrbZIP1 wasconstructed and transferred into tobacco (Nicotiana tabacumL. cv Xanthi). The results of Southern blotting andqRT-PCR analyses demonstrated that the LrbZIP1 wasintegrated into genome of the tobacco transformants andhighly expressed. Under normal conditions, the T1 transgenictobacco lines showed higher antioxidant enzymeactivities and transcription levels of several resistancerelatedgenes than the wild type. Moreover, the T1 transgenictobacco plants showed strong resistance to F. oxysporumf. sp. lilii infection.
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