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항암항생제 Daunorubicin의 Aglycone, 7,9-Dideoxydaunomycinone의 합성 (제1보)
조인호,이풍래,노영쇠,In Ho Cho,Richard P. Rhee,Young Soy Rho,F. M. Hauser 대한화학회 1986 대한화학회지 Vol.30 No.1
항암항생제 Daunorubicin(2a)합성단계의 최종물질인 7,9-Dideoxydaunomycinone (32)를 3-methoxybenzoic acid(5)로 부터 합성하였다. 3-methoxybenzoic acid를 4-methoxy-3-(phenylsulfonyl)-1(3H)-isobenzofuranone(11)으로 변형시킨 뒤 Hauser와 Rhee가 개발한 고리접합법을 이용하여 trimethoxynaphthoate 16을 얻은 후에 phenylsulfonylnaphthofuranone 22로 변화시킨 뒤 이 물질을 7-(ethylenedioxy)-2-octenoate(23)과 Michael형태의 반응을 전개시켜 anthracenoate 24를 얻었다. Anthracenoate을 tetracyclic 화합물 28로 바꾼뒤 ring B와 C에 붙은 methyl기들을 제거하여 7,9-Dideoxydaunomycinone(32)를 만들었다. 7,9-Dideoxydaunomycinone (32), a late-stage precursor of the aglycone of antitumor antibiotic daunorubicin(2a) was prepared from 3-methoxybenzoic acid(5). Thus, 3-methoxybenzoic acid was converted to 4-methoxy-3-(phenylsulfonyl)-1(3H)-isobenzofuranone(11), which furnished trimethoxynaphthoate 16 upon ring annelation developed by Hauser and Rhee. The trimethoxynaphthoate 16 upon ring annelation developed by Hauser and Rbee. The trimethoxynaphtboate 16 was then transformed into phenylsulfonylnaphthofuranone 22, which was used to make anthracenoate 24 via Michael type reaction with 7-(ethylenedioxy)-2-octenoate(23). Conversion of anthracenoate 24 to tetracyclic product 28, followed by subsequent deprotection of the methyl groups in ring-B and C furnished 7, 9-Dideoxydaunomycinone(32).
Hauser, Frank M,Hewawasam, Piyasenan,Rho, Young S 全北大學校 基礎科學硏究所 1991 基礎科學 Vol.14 No.1
A brief route for total synthesis of(±)-aklavinone(1a), the aglycon of the anticancer antibiotic aclacinomycin(1b), is described. Key features of the synthesis are the development of a brief, efficient route to the 1(4H)-naphthalenone 1l, which was used as a synthon for the A and B rings, and homologation of keto aldehyde 17 to the keto anthraquinone acetic ester 16 via the intermediacy of the ketene thioacetal 19.
Stereisoecific Syntheses of (E)-1,3-Disubstituted Dienes
Hauser, Frank M.,Tommasi, Ruben,Hewawasam, Piyasena,Rho, Young S. 全北大學校 基礎科學硏究所 1999 基礎科學 Vol.14 No.1
In summary, the palladium-catalyzed conversion of allylacetates with a 2-alkyl group on the vinyl moiety provides a general, high-yield route for selective syntheses of E isomers of 1,3-disubstituted dienes. The reaction conditions are mild and compatible with a variety of functional groups elsewhere in the molecule. Currently, we are ap-plying these results to other synthetic work, which will be reported shortly.
Measurements of the External Luminescence Quantum Efficiency of Zinc Oxide
Mario Hauser,Alexander Hepting,Robert Hauschild,Markus Wissinger,Huijuan Zhou,Felix Stelzl,Johannes Fallert,Heinz Kalt,Claus Klingshirn 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.5
We report on the measurement of the absolute external luminescence quantum efficiency that is directly accessible using a miniature integrating sphere fitted into a cryostat. Various measurements have been carried out on high quality laboratory bulk samples and dierent commercially available ZnO powders from 10 K up to room temperature. A fit to the temperature dependent quantum efficiency shows the existence of various activated processes. We report on the measurement of the absolute external luminescence quantum efficiency that is directly accessible using a miniature integrating sphere fitted into a cryostat. Various measurements have been carried out on high quality laboratory bulk samples and dierent commercially available ZnO powders from 10 K up to room temperature. A fit to the temperature dependent quantum efficiency shows the existence of various activated processes.
Functional Gastrointestinal Disorders in Infancy: Impact on the Health of the Infant and Family
Vandenplas, Yvan,Hauser, Bruno,Salvatore, Silvia The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.3
Functional gastrointestinal disorders (FGIDs) such as infantile colic, constipation and colic occur in almost half of the infants. The aim of this paper is to provide a critical and updated review on the management of FGIDs and their impact on the health of the infant and family to health care physicians. Guidelines and expert recommendations were reviewed. FGIDs are a frequent cause of parental concern, impairment in quality of life of infants and relatives, and impose a financial burden to families, health care, and insurance. Therefore, primary management of the FGIDs should be focused on improving the infants' symptoms and quality of life of the family. If more than parental reassurance is needed, available evidence recommends nutritional advice as it is an effective strategy and most of the time devoid of adverse effects. The role of healthcare providers in reassuring parents and proposing the correct behavior and nutritional intervention by avoiding inappropriate use of medication, is essential in the management of FGIDs.
Gonzalez Ayerbe, Jeaneth Indira,Hauser, Bruno,Salvatore, Silvia,Vandenplas, Yvan The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.2
The diagnosis and management of gastro-esophageal reflux (GER) and GER disease (GERD) in infants and children remains a challenge. Published guidelines and position papers, along with Embase, MEDLINE, and the Cochrane Database were reviewed and summarized with the intent to propose a practical approach and management of GER and GERD for healthcare providers and to standardize and improve the quality of care for infants and children. For this purpose, 2 algorithms were developed, 1 for infants <12 months of age and the other for older children. None of the signs and symptoms of GER and GERD are specific and there is no gold standard diagnostic test or tool. Nutritional management is recommended as a first-line approach in infants, while in children, a therapeutic trial with antacid medication is advised for early management. The practical recommendations from this review are intended to optimize the management of GER in infants and older children and reduce the number of investigations and inappropriate use of medication.